The immunopathology of sepsis and potential therapeutic targets View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2017-04-24

AUTHORS

Tom van der Poll, Frank L. van de Veerdonk, Brendon P. Scicluna, Mihai G. Netea

ABSTRACT

Sepsis is defined as a life-threatening organ dysfunction that is caused by a dysregulated host response to infection. In sepsis, the immune response that is initiated by an invading pathogen fails to return to homeostasis, thus culminating in a pathological syndrome that is characterized by sustained excessive inflammation and immune suppression. Our understanding of the key mechanisms involved in the pathogenesis of sepsis has increased tremendously, yet this still needs to be translated into novel targeted therapeutic strategies. Pivotal for the clinical development of new sepsis therapies is the selection of patients on the basis of biomarkers and/or functional defects that provide specific insights into the expression or activity of the therapeutic target. More... »

PAGES

407-420

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nri.2017.36

    DOI

    http://dx.doi.org/10.1038/nri.2017.36

    DIMENSIONS

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    PUBMED

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