Interleukin-33 in health and disease View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2016-11

AUTHORS

Foo Yew Liew, Jean-Philippe Girard, Heth Roderick Turnquist

ABSTRACT

Interleukin-33 (IL-33) - a member of the IL-1 family - was originally described as an inducer of type 2 immune responses, activating T helper 2 (TH2) cells and mast cells. Now, evidence is accumulating that IL-33 also potently stimulates group 2 innate lymphoid cells (ILC2s), regulatory T (Treg) cells, TH1 cells, CD8+ T cells and natural killer (NK) cells. This pleiotropic nature is reflected in the role of IL-33 in tissue and metabolic homeostasis, infection, inflammation, cancer and diseases of the central nervous system. In this Review, we highlight the molecular and cellular characteristics of IL-33, together with its major role in health and disease and the potential therapeutic implications of these findings in humans. More... »

PAGES

676-689

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    http://scigraph.springernature.com/pub.10.1038/nri.2016.95

    DOI

    http://dx.doi.org/10.1038/nri.2016.95

    DIMENSIONS

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    PUBMED

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