Harnessing the beneficial heterologous effects of vaccination View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2016-06

AUTHORS

Helen S Goodridge, S Sohail Ahmed, Nigel Curtis, Tobias R Kollmann, Ofer Levy, Mihai G Netea, Andrew J Pollard, Reinout van Crevel, Christopher B Wilson

ABSTRACT

Clinical evidence strongly suggests that certain live vaccines, in particular bacille Calmette-Guérin (BCG) and measles vaccines, can reduce all-cause mortality, most probably through protection against non-targeted pathogens in addition to the targeted pathogen. The underlying mechanisms are currently unknown. We discuss how heterologous lymphocyte activation and innate immune memory could promote protection beyond the intended target pathogen and consider how vaccinologists could leverage heterologous immunity to improve outcomes in vulnerable populations, in particular the very young and the elderly. More... »

PAGES

392-400

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nri.2016.43

DOI

http://dx.doi.org/10.1038/nri.2016.43

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1047371749

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/27157064


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