Dendritic cell migration in health and disease View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2016-11-28

AUTHORS

Tim Worbs, Swantje I. Hammerschmidt, Reinhold Förster

ABSTRACT

Key PointsDuring embryonic development and postnatally, dendritic cell (DC) progenitors migrate into non-lymphoid organs and differentiate into immature DCs.Immature DCs form a dense network of sentinel cells at all outer and inner surfaces of the body, as well as in most organs.Immature DCs sample and process both self and foreign antigens. They subsequently undergo an activation process that is triggered by either an 'intrinsic programme' or in response to the recognition of molecular patterns associated with pathogens and the microbiota.As part of the activation programme, DCs upregulate CC-chemokine receptor 7 (CCR7) and increase their motility. The CCR7 ligand CC-chemokine ligand 21 (CCL21) is expressed on terminal lymphatics and CCR7–CCL21 interactions enable DCs to enter the lymphatic vasculature and eventually the draining lymph node, where they migrate into the T cell-rich paracortex.Within lymph nodes and other lymphoid organs, DCs present antigen to T cells, leading either to the induction of immunological tolerance or to the expansion of protective pro-inflammatory effector and memory T cell populations. In some cases, DC-mediated presentation of self or harmless foreign antigens leads to the formation of effector T cell populations; as such, DCs can contribute to the development of autoimmune or allergic diseases.Effector T cells that develop during protective immune responses home to the tissue site of infection and inflammation and frequently contribute to the recruitment of further DC progenitors. Following their differentiation, such progenitors can present antigen to T cells, either locally or — after mobilization — in draining lymph nodes, thus amplifying protective as well as detrimental immune responses. More... »

PAGES

30-48

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    http://scigraph.springernature.com/pub.10.1038/nri.2016.116

    DOI

    http://dx.doi.org/10.1038/nri.2016.116

    DIMENSIONS

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    PUBMED

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