Anti-HER agents in gastric cancer: from bench to bedside View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2011-07

AUTHORS

Lorenzo Fornaro, Maurizio Lucchesi, Chiara Caparello, Enrico Vasile, Sara Caponi, Laura Ginocchi, Gianluca Masi, Alfredo Falcone

ABSTRACT

Despite some advances in the past few years, the search for effective treatment modalities for advanced gastric and gastro-esophageal junction cancer is far from over. Available data clearly demonstrate that the development of new drugs will have little, if any, chance of success if it is not guided by in-depth knowledge of disease biology. However, using biologic agents to target key molecular pathways, such as those regulated by human epidermal growth factor receptor (HER) family members, may be effective. Indeed, the positive results achieved by the anti-HER2 agent trastuzumab in a phase III trial in HER2-positive patients support this approach. Many new anti-HER molecules are now under evaluation for the treatment of gastric and gastro-esophageal junction cancer, but so far attempts to identify reliable predictive factors from phase I and II trials have produced inconclusive results. In addition, large phase III trials are still being conducted in molecularly unselected populations. Refining patient selection is essential to maximize the benefit of targeted agents, to avoid significant toxicities and for the development of alternative therapeutic approaches in patients who have nonresponsive disease. More... »

PAGES

369

References to SciGraph publications

  • 2012-03. Phase II study of everolimus with biomarker exploration in patients with advanced gastric cancer refractory to chemotherapy including fluoropyrimidine and platinum in BRITISH JOURNAL OF CANCER
  • 2009-01. Phase II study and biomarker analysis of cetuximab combined with modified FOLFOX6 in advanced gastric cancer in BRITISH JOURNAL OF CANCER
  • 2006-06. Humanization of a recombinant monoclonal antibody to produce a therapeutic HER dimerization inhibitor, pertuzumab in CANCER IMMUNOLOGY, IMMUNOTHERAPY
  • 2010-02. Molecular predictors of response to trastuzumab and lapatinib in breast cancer in NATURE REVIEWS CLINICAL ONCOLOGY
  • 2010-09. HER2 diagnostics in gastric cancer—guideline validation and development of standardized immunohistochemical testing in VIRCHOWS ARCHIV
  • 2008-02. Impacts of excision repair cross-complementing gene 1 (ERCC1), dihydropyrimidine dehydrogenase, and epidermal growth factor receptor on the outcomes of patients with advanced gastric cancer in BRITISH JOURNAL OF CANCER
  • 2003-10. BRAF and KRAS mutations in stomach cancer in ONCOGENE
  • 2007-03. Epidermal growth factor receptor mutations in lung cancer in NATURE REVIEWS CANCER
  • 2009-09. Implications for KRAS status and EGFR-targeted therapies in metastatic CRC in NATURE REVIEWS CLINICAL ONCOLOGY
  • 2010-02. Predictive factors for the efficacy of cetuximab plus chemotherapy as salvage therapy in metastatic gastric cancer patients in CANCER CHEMOTHERAPY AND PHARMACOLOGY
  • 2010-02. Cetuximab plus oxaliplatin/leucovorin/5-fluorouracil in first-line metastatic gastric cancer: a phase II study of the Arbeitsgemeinschaft Internistische Onkologie (AIO) in BRITISH JOURNAL OF CANCER
  • 2008-01. Expression of Vascular Endothelial Growth Factor (VEGF) and Epidermal Growth Factor Receptor (EGFR) is an Independent Prognostic Indicator of Worse Outcome in Gastric Cancer Patients in ANNALS OF SURGICAL ONCOLOGY
  • 2011-02. The Need to Examine Metastatic Tissue at the Time of Progression of Breast Cancer: Is Re-biopsy a Necessity or a Luxury? in CURRENT ONCOLOGY REPORTS
  • 2011-04. A prospective phase II study of cetuximab in combination with XELOX (capecitabine and oxaliplatin) in patients with metastatic and/or recurrent advanced gastric cancer in INVESTIGATIONAL NEW DRUGS
  • 2009-10. Phase II study of cetuximab in combination with cisplatin and docetaxel in patients with untreated advanced gastric or gastro-oesophageal junction adenocarcinoma (DOCETUX study) in BRITISH JOURNAL OF CANCER
  • 2002-08. Tumorigenesis: RAF/RAS oncogenes and mismatch-repair status in NATURE
  • 2003-12. BRAF mutations characterize colon but not gastric cancer with mismatch repair deficiency in ONCOGENE
  • 2000-01. Determination of Her-2/Neu Status in Breast Carcinoma: Comparative Analysis of Immunohistochemistry and Fluorescent In Situ Hybridization in MODERN PATHOLOGY
  • 2004-05. Epidermal growth factor receptor expression correlates with poor survival in gastric adenocarcinoma from Mexican patients: a multivariate analysis using a standardized immunohistochemical detection system in MODERN PATHOLOGY
  • 2006-12. Molecular basis for sensitivity and acquired resistance to gefitinib in HER2-overexpressing human gastric cancer cell lines derived from liver metastasis in BRITISH JOURNAL OF CANCER
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nrgastro.2011.81

    DOI

    http://dx.doi.org/10.1038/nrgastro.2011.81

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1000724233

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/21647199


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Oncology and Carcinogenesis", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Antibodies, Monoclonal", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Antineoplastic Agents", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Esophageal Neoplasms", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Esophagogastric Junction", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Receptor, Epidermal Growth Factor", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Receptor, ErbB-2", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Stomach Neoplasms", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Treatment Outcome", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Azienda Ospedaliera Universitaria Pisana", 
              "id": "https://www.grid.ac/institutes/grid.144189.1", 
              "name": [
                "U.O. Oncologia Medica 2 Universitaria, Azienda Ospedaliero-Universitaria Pisana, Istituto Toscano-Tumori, Via Roma 67, 56126 Pisa, Italy"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Fornaro", 
            "givenName": "Lorenzo", 
            "id": "sg:person.01164506727.84", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01164506727.84"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Azienda Ospedaliera Universitaria Pisana", 
              "id": "https://www.grid.ac/institutes/grid.144189.1", 
              "name": [
                "U.O. Oncologia Medica 2 Universitaria, Azienda Ospedaliero-Universitaria Pisana, Istituto Toscano-Tumori, Via Roma 67, 56126 Pisa, Italy"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Lucchesi", 
            "givenName": "Maurizio", 
            "id": "sg:person.01165207053.41", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01165207053.41"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Azienda Ospedaliera Universitaria Pisana", 
              "id": "https://www.grid.ac/institutes/grid.144189.1", 
              "name": [
                "U.O. Oncologia Medica 2 Universitaria, Azienda Ospedaliero-Universitaria Pisana, Istituto Toscano-Tumori, Via Roma 67, 56126 Pisa, Italy"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Caparello", 
            "givenName": "Chiara", 
            "id": "sg:person.01012133613.37", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01012133613.37"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Azienda Ospedaliera Universitaria Pisana", 
              "id": "https://www.grid.ac/institutes/grid.144189.1", 
              "name": [
                "U.O. Oncologia Medica 2 Universitaria, Azienda Ospedaliero-Universitaria Pisana, Istituto Toscano-Tumori, Via Roma 67, 56126 Pisa, Italy"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Vasile", 
            "givenName": "Enrico", 
            "id": "sg:person.01006607213.66", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01006607213.66"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Azienda Ospedaliera Universitaria Pisana", 
              "id": "https://www.grid.ac/institutes/grid.144189.1", 
              "name": [
                "U.O. Oncologia Medica 2 Universitaria, Azienda Ospedaliero-Universitaria Pisana, Istituto Toscano-Tumori, Via Roma 67, 56126 Pisa, Italy"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Caponi", 
            "givenName": "Sara", 
            "id": "sg:person.01170634313.13", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01170634313.13"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Azienda Ospedaliera Universitaria Pisana", 
              "id": "https://www.grid.ac/institutes/grid.144189.1", 
              "name": [
                "U.O. Oncologia Medica 2 Universitaria, Azienda Ospedaliero-Universitaria Pisana, Istituto Toscano-Tumori, Via Roma 67, 56126 Pisa, Italy"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ginocchi", 
            "givenName": "Laura", 
            "id": "sg:person.01305062713.70", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01305062713.70"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Azienda Ospedaliera Universitaria Pisana", 
              "id": "https://www.grid.ac/institutes/grid.144189.1", 
              "name": [
                "U.O. Oncologia Medica 2 Universitaria, Azienda Ospedaliero-Universitaria Pisana, Istituto Toscano-Tumori, Via Roma 67, 56126 Pisa, Italy"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Masi", 
            "givenName": "Gianluca", 
            "id": "sg:person.01062670207.83", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01062670207.83"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Azienda Ospedaliera Universitaria Pisana", 
              "id": "https://www.grid.ac/institutes/grid.144189.1", 
              "name": [
                "U.O. Oncologia Medica 2 Universitaria, Azienda Ospedaliero-Universitaria Pisana, Istituto Toscano-Tumori, Via Roma 67, 56126 Pisa, Italy"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Falcone", 
            "givenName": "Alfredo", 
            "id": "sg:person.01006230145.44", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01006230145.44"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "https://doi.org/10.1200/jco.2010.29.2847", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000659580"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1517/14656560903427997", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000911604"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1349-7006.2009.01447.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001573295"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1349-7006.2009.01447.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001573295"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1200/jco.2009.24.2024", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001727306"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/ijc.11553", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002458841"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.bjc.6605521", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003673412", 
              "https://doi.org/10.1038/sj.bjc.6605521"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.bjc.6605521", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003673412", 
              "https://doi.org/10.1038/sj.bjc.6605521"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.bjc.6604861", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004443137", 
              "https://doi.org/10.1038/sj.bjc.6604861"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/annonc/mdq247", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004875896"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/1078-0432.ccr-09-1112", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005686924"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/0008-5472.can-03-3856", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006401030"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/0008-5472.can-03-3856", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006401030"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/1078-0432.ccr-07-5165", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006825659"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrclinonc.2009.111", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007415410", 
              "https://doi.org/10.1038/nrclinonc.2009.111"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrclinonc.2009.111", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007415410", 
              "https://doi.org/10.1038/nrclinonc.2009.111"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1200/jco.2009.25.8707", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007511412"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00428-010-0952-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008262506", 
              "https://doi.org/10.1007/s00428-010-0952-2"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3322/caac.20107", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009055747"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1200/jco.2008.20.2796", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009529915"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.bjc.6605319", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010815314", 
              "https://doi.org/10.1038/sj.bjc.6605319"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.bjc.6605319", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010815314", 
              "https://doi.org/10.1038/sj.bjc.6605319"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/1097-0142(19950615)75:12<2794::aid-cncr2820751203>3.0.co;2-f", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010985497"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/1097-0142(19950315)75:6+<1418::aid-cncr2820751505>3.0.co;2-y", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011117491"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/0008-5472-can-04-3913", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011326721"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/modpathol.3880007", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011441671", 
              "https://doi.org/10.1038/modpathol.3880007"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/modpathol.3880007", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011441671", 
              "https://doi.org/10.1038/modpathol.3880007"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1634/theoncologist.8-suppl_3-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011456337"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1634/theoncologist.2008-0181", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011763643"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/(sici)1521-1878(199801)20:1<41::aid-bies7>3.0.co;2-v", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013765345"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1200/jco.2008.21.3744", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013781784"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0305-7372(10)70014-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015992849"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ccr.2004.06.022", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016986102"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/path.971", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017034982"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.onc.1206749", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018108900", 
              "https://doi.org/10.1038/sj.onc.1206749"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.onc.1206749", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018108900", 
              "https://doi.org/10.1038/sj.onc.1206749"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/0008-5472.can-06-2101", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018366044"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1245/s10434-007-9596-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018777047", 
              "https://doi.org/10.1245/s10434-007-9596-0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00280-009-1067-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018932393", 
              "https://doi.org/10.1007/s00280-009-1067-9"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00280-009-1067-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018932393", 
              "https://doi.org/10.1007/s00280-009-1067-9"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00280-009-1067-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018932393", 
              "https://doi.org/10.1007/s00280-009-1067-9"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/jnci/93.24.1852", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022747550"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ctrv.2010.01.005", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023167426"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1159/000288295", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023747586"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s11912-010-0137-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024155571", 
              "https://doi.org/10.1007/s11912-010-0137-9"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s11912-010-0137-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024155571", 
              "https://doi.org/10.1007/s11912-010-0137-9"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1200/jco.2006.10.5437", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024397161"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1200/jco.2006.07.1316", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024659261"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1200/jco.2010.29.1807", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026214238"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0140-6736(09)60569-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026273347"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/annonc/mdn169", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026667587"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1200/jco.2009.24.8617", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028057056"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1200/jco.2009.22.6605", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028158072"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1200/jco.2009.24.1661", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028339567"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1200/jco.2009.24.6116", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028622217"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejmoa0808268", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029533783"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1200/jco.2007.12.4602", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029961377"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/bjc.2012.47", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030389345", 
              "https://doi.org/10.1038/bjc.2012.47"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.onc.1207061", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030493697", 
              "https://doi.org/10.1038/sj.onc.1207061"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.onc.1207061", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030493697", 
              "https://doi.org/10.1038/sj.onc.1207061"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1053/j.seminoncol.2004.04.021", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031576130"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejmoa0802656", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031603011"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.yexcr.2004.12.008", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031908758"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrc2088", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032628685", 
              "https://doi.org/10.1038/nrc2088"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/01.cco.0000155059.39733.9d", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032911688"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/01.cco.0000155059.39733.9d", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032911688"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0959-8049(01)00230-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033094712"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3816/cbc.2008.n.047", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033182820"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ctrv.2009.04.008", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033676438"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ccr.2007.08.030", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034133737"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/0008-5472.can-08-1740", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034617811"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3233/clo-2009-0497", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034695709"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejmoa033025", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035161767"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.bjc.6604211", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035664868", 
              "https://doi.org/10.1038/sj.bjc.6604211"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1200/jco.2009.27.5388", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035845707"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ejca.2010.03.017", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037548521"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1200/jco.2010.29.3407", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037902142"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1470-2045(10)70125-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038036425"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00262-005-0058-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038243318", 
              "https://doi.org/10.1007/s00262-005-0058-x"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00262-005-0058-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038243318", 
              "https://doi.org/10.1007/s00262-005-0058-x"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/annonc/mdi064", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039835370"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/annonc/mdq706", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039876871"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1172/jci36049", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040013987"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/modpathol.3800085", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041581944", 
              "https://doi.org/10.1038/modpathol.3800085"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/modpathol.3800085", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041581944", 
              "https://doi.org/10.1038/modpathol.3800085"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/418934a", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042017236", 
              "https://doi.org/10.1038/418934a"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/418934a", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042017236", 
              "https://doi.org/10.1038/418934a"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1365-3083.1994.tb03401.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042091110"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1365-2559.2008.03028.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042540498"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/annonc/mdl459", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043337256"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0305-7372(10)70002-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043341479"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1200/jco.2007.13.9949", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043392679"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0140-6736(10)61121-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044182432"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.bjc.6603459", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045932147", 
              "https://doi.org/10.1038/sj.bjc.6603459"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.bjc.6603459", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045932147", 
              "https://doi.org/10.1038/sj.bjc.6603459"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1365-2559.2011.03760.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046023288"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1200/jco.2008.19.8135", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046046620"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10637-009-9363-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046585078", 
              "https://doi.org/10.1007/s10637-009-9363-0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0065-230x(09)02002-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047562265"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1200/jco.2009.23.3452", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047799543"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.critrevonc.2009.01.004", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048746404"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1200/jco.2005.02.4646", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049107817"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrclinonc.2009.216", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049327283", 
              "https://doi.org/10.1038/nrclinonc.2009.216"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrclinonc.2009.216", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049327283", 
              "https://doi.org/10.1038/nrclinonc.2009.216"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/1078-0432.ccr-06-1304", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049548242"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ctrv.2009.12.009", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049783583"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/annonc/mdq591", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050287251"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1200/jco.2009.25.2890", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051122376"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/jnci/djp280", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051366374"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1359-6349(09)71233-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051623230"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ejca.2010.05.003", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052132896"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.274.19.13176", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052475518"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1200/jco.2010.32.9615", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052513014"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/0008-5472.can-08-4597", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053676255"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0016-5085(90)90019-w", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1054543859"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1200/jco.2005.05.2308", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064204262"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3892/or.15.1.65", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1071529842"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1200/jco.2000.18.21.3651", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1074719576"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1200/jco.2001.19.2.354", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1074768320"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1074779314", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1075274588", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1077243466", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1078292383", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1200/jco.2008.26.15_suppl.15587", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1079370865"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1200/jco.2008.26.15_suppl.15554", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1079371013"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/jnci/77.5.1047", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1079764985"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1082504447", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1200/jco.2010.28.15_suppl.4133", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1083943272"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1200/jco.2011.29.4_suppl.93", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1083951832"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2011-07", 
        "datePublishedReg": "2011-07-01", 
        "description": "Despite some advances in the past few years, the search for effective treatment modalities for advanced gastric and gastro-esophageal junction cancer is far from over. Available data clearly demonstrate that the development of new drugs will have little, if any, chance of success if it is not guided by in-depth knowledge of disease biology. However, using biologic agents to target key molecular pathways, such as those regulated by human epidermal growth factor receptor (HER) family members, may be effective. Indeed, the positive results achieved by the anti-HER2 agent trastuzumab in a phase III trial in HER2-positive patients support this approach. Many new anti-HER molecules are now under evaluation for the treatment of gastric and gastro-esophageal junction cancer, but so far attempts to identify reliable predictive factors from phase I and II trials have produced inconclusive results. In addition, large phase III trials are still being conducted in molecularly unselected populations. Refining patient selection is essential to maximize the benefit of targeted agents, to avoid significant toxicities and for the development of alternative therapeutic approaches in patients who have nonresponsive disease.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1038/nrgastro.2011.81", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": false, 
        "isPartOf": [
          {
            "id": "sg:journal.1294865", 
            "issn": [
              "1759-5045", 
              "1759-5053"
            ], 
            "name": "Nature Reviews Gastroenterology & Hepatology", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "7", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "8"
          }
        ], 
        "name": "Anti-HER agents in gastric cancer: from bench to bedside", 
        "pagination": "369", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "0372f27d08e98bd0645bdc67da72d2a2fc93f91531c87853094c59681199fe4b"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "21647199"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "101500079"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1038/nrgastro.2011.81"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1000724233"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1038/nrgastro.2011.81", 
          "https://app.dimensions.ai/details/publication/pub.1000724233"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-10T13:57", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8660_00000436.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://www.nature.com/articles/nrgastro.2011.81"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/nrgastro.2011.81'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/nrgastro.2011.81'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/nrgastro.2011.81'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/nrgastro.2011.81'


     

    This table displays all metadata directly associated to this object as RDF triples.

    505 TRIPLES      21 PREDICATES      150 URIs      30 LITERALS      18 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1038/nrgastro.2011.81 schema:about N30fcfec2893f437ab19ef29d48b302a2
    2 N331821cfccf04124b36084bcdf39e1bb
    3 N4968163de3fa4b99afa95673677ae36d
    4 N9313154538394c52bc45b9c34c23178e
    5 Nb2f53d870d3b4fa7b96b3998125c2556
    6 Nb67b27f8f2df4b54887145784e7e5c53
    7 Nb7848239586d4f1f92a87e12c896b0aa
    8 Nba2cd780d18b413a85c4857da651830e
    9 Ne360c68bc62145078192bea63f03aaea
    10 anzsrc-for:11
    11 anzsrc-for:1112
    12 schema:author N9bddf06bb1b146599bd7a16d7ff3ff95
    13 schema:citation sg:pub.10.1007/s00262-005-0058-x
    14 sg:pub.10.1007/s00280-009-1067-9
    15 sg:pub.10.1007/s00428-010-0952-2
    16 sg:pub.10.1007/s10637-009-9363-0
    17 sg:pub.10.1007/s11912-010-0137-9
    18 sg:pub.10.1038/418934a
    19 sg:pub.10.1038/bjc.2012.47
    20 sg:pub.10.1038/modpathol.3800085
    21 sg:pub.10.1038/modpathol.3880007
    22 sg:pub.10.1038/nrc2088
    23 sg:pub.10.1038/nrclinonc.2009.111
    24 sg:pub.10.1038/nrclinonc.2009.216
    25 sg:pub.10.1038/sj.bjc.6603459
    26 sg:pub.10.1038/sj.bjc.6604211
    27 sg:pub.10.1038/sj.bjc.6604861
    28 sg:pub.10.1038/sj.bjc.6605319
    29 sg:pub.10.1038/sj.bjc.6605521
    30 sg:pub.10.1038/sj.onc.1206749
    31 sg:pub.10.1038/sj.onc.1207061
    32 sg:pub.10.1245/s10434-007-9596-0
    33 https://app.dimensions.ai/details/publication/pub.1074779314
    34 https://app.dimensions.ai/details/publication/pub.1075274588
    35 https://app.dimensions.ai/details/publication/pub.1077243466
    36 https://app.dimensions.ai/details/publication/pub.1078292383
    37 https://app.dimensions.ai/details/publication/pub.1082504447
    38 https://doi.org/10.1002/(sici)1521-1878(199801)20:1<41::aid-bies7>3.0.co;2-v
    39 https://doi.org/10.1002/1097-0142(19950315)75:6+<1418::aid-cncr2820751505>3.0.co;2-y
    40 https://doi.org/10.1002/1097-0142(19950615)75:12<2794::aid-cncr2820751203>3.0.co;2-f
    41 https://doi.org/10.1002/ijc.11553
    42 https://doi.org/10.1002/path.971
    43 https://doi.org/10.1016/0016-5085(90)90019-w
    44 https://doi.org/10.1016/j.ccr.2004.06.022
    45 https://doi.org/10.1016/j.ccr.2007.08.030
    46 https://doi.org/10.1016/j.critrevonc.2009.01.004
    47 https://doi.org/10.1016/j.ctrv.2009.04.008
    48 https://doi.org/10.1016/j.ctrv.2009.12.009
    49 https://doi.org/10.1016/j.ctrv.2010.01.005
    50 https://doi.org/10.1016/j.ejca.2010.03.017
    51 https://doi.org/10.1016/j.ejca.2010.05.003
    52 https://doi.org/10.1016/j.yexcr.2004.12.008
    53 https://doi.org/10.1016/s0065-230x(09)02002-8
    54 https://doi.org/10.1016/s0140-6736(09)60569-9
    55 https://doi.org/10.1016/s0140-6736(10)61121-x
    56 https://doi.org/10.1016/s0305-7372(10)70002-5
    57 https://doi.org/10.1016/s0305-7372(10)70014-1
    58 https://doi.org/10.1016/s0959-8049(01)00230-1
    59 https://doi.org/10.1016/s1359-6349(09)71233-9
    60 https://doi.org/10.1016/s1470-2045(10)70125-x
    61 https://doi.org/10.1053/j.seminoncol.2004.04.021
    62 https://doi.org/10.1056/nejmoa033025
    63 https://doi.org/10.1056/nejmoa0802656
    64 https://doi.org/10.1056/nejmoa0808268
    65 https://doi.org/10.1074/jbc.274.19.13176
    66 https://doi.org/10.1093/annonc/mdi064
    67 https://doi.org/10.1093/annonc/mdl459
    68 https://doi.org/10.1093/annonc/mdn169
    69 https://doi.org/10.1093/annonc/mdq247
    70 https://doi.org/10.1093/annonc/mdq591
    71 https://doi.org/10.1093/annonc/mdq706
    72 https://doi.org/10.1093/jnci/77.5.1047
    73 https://doi.org/10.1093/jnci/93.24.1852
    74 https://doi.org/10.1093/jnci/djp280
    75 https://doi.org/10.1097/01.cco.0000155059.39733.9d
    76 https://doi.org/10.1111/j.1349-7006.2009.01447.x
    77 https://doi.org/10.1111/j.1365-2559.2008.03028.x
    78 https://doi.org/10.1111/j.1365-2559.2011.03760.x
    79 https://doi.org/10.1111/j.1365-3083.1994.tb03401.x
    80 https://doi.org/10.1158/0008-5472-can-04-3913
    81 https://doi.org/10.1158/0008-5472.can-03-3856
    82 https://doi.org/10.1158/0008-5472.can-06-2101
    83 https://doi.org/10.1158/0008-5472.can-08-1740
    84 https://doi.org/10.1158/0008-5472.can-08-4597
    85 https://doi.org/10.1158/1078-0432.ccr-06-1304
    86 https://doi.org/10.1158/1078-0432.ccr-07-5165
    87 https://doi.org/10.1158/1078-0432.ccr-09-1112
    88 https://doi.org/10.1159/000288295
    89 https://doi.org/10.1172/jci36049
    90 https://doi.org/10.1200/jco.2000.18.21.3651
    91 https://doi.org/10.1200/jco.2001.19.2.354
    92 https://doi.org/10.1200/jco.2005.02.4646
    93 https://doi.org/10.1200/jco.2005.05.2308
    94 https://doi.org/10.1200/jco.2006.07.1316
    95 https://doi.org/10.1200/jco.2006.10.5437
    96 https://doi.org/10.1200/jco.2007.12.4602
    97 https://doi.org/10.1200/jco.2007.13.9949
    98 https://doi.org/10.1200/jco.2008.19.8135
    99 https://doi.org/10.1200/jco.2008.20.2796
    100 https://doi.org/10.1200/jco.2008.21.3744
    101 https://doi.org/10.1200/jco.2008.26.15_suppl.15554
    102 https://doi.org/10.1200/jco.2008.26.15_suppl.15587
    103 https://doi.org/10.1200/jco.2009.22.6605
    104 https://doi.org/10.1200/jco.2009.23.3452
    105 https://doi.org/10.1200/jco.2009.24.1661
    106 https://doi.org/10.1200/jco.2009.24.2024
    107 https://doi.org/10.1200/jco.2009.24.6116
    108 https://doi.org/10.1200/jco.2009.24.8617
    109 https://doi.org/10.1200/jco.2009.25.2890
    110 https://doi.org/10.1200/jco.2009.25.8707
    111 https://doi.org/10.1200/jco.2009.27.5388
    112 https://doi.org/10.1200/jco.2010.28.15_suppl.4133
    113 https://doi.org/10.1200/jco.2010.29.1807
    114 https://doi.org/10.1200/jco.2010.29.2847
    115 https://doi.org/10.1200/jco.2010.29.3407
    116 https://doi.org/10.1200/jco.2010.32.9615
    117 https://doi.org/10.1200/jco.2011.29.4_suppl.93
    118 https://doi.org/10.1517/14656560903427997
    119 https://doi.org/10.1634/theoncologist.2008-0181
    120 https://doi.org/10.1634/theoncologist.8-suppl_3-5
    121 https://doi.org/10.3233/clo-2009-0497
    122 https://doi.org/10.3322/caac.20107
    123 https://doi.org/10.3816/cbc.2008.n.047
    124 https://doi.org/10.3892/or.15.1.65
    125 schema:datePublished 2011-07
    126 schema:datePublishedReg 2011-07-01
    127 schema:description Despite some advances in the past few years, the search for effective treatment modalities for advanced gastric and gastro-esophageal junction cancer is far from over. Available data clearly demonstrate that the development of new drugs will have little, if any, chance of success if it is not guided by in-depth knowledge of disease biology. However, using biologic agents to target key molecular pathways, such as those regulated by human epidermal growth factor receptor (HER) family members, may be effective. Indeed, the positive results achieved by the anti-HER2 agent trastuzumab in a phase III trial in HER2-positive patients support this approach. Many new anti-HER molecules are now under evaluation for the treatment of gastric and gastro-esophageal junction cancer, but so far attempts to identify reliable predictive factors from phase I and II trials have produced inconclusive results. In addition, large phase III trials are still being conducted in molecularly unselected populations. Refining patient selection is essential to maximize the benefit of targeted agents, to avoid significant toxicities and for the development of alternative therapeutic approaches in patients who have nonresponsive disease.
    128 schema:genre research_article
    129 schema:inLanguage en
    130 schema:isAccessibleForFree false
    131 schema:isPartOf N134de91d1038472797d7181d1b0996ab
    132 N146093594e8540d4b90388e4fc0218ac
    133 sg:journal.1294865
    134 schema:name Anti-HER agents in gastric cancer: from bench to bedside
    135 schema:pagination 369
    136 schema:productId N54a384b70cb64796b2420f1ccdcc1d86
    137 N5b69a632ff144f79ab8f7378208cbad4
    138 N968dccc49cc44e1db7ba45cccd3dca55
    139 Ne50b93d6f267436899c1d35d6d76f206
    140 Nf6f7fc439d8e428d936e1b211d6784c2
    141 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000724233
    142 https://doi.org/10.1038/nrgastro.2011.81
    143 schema:sdDatePublished 2019-04-10T13:57
    144 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    145 schema:sdPublisher N867696c7f57d4e81b5b754be14583577
    146 schema:url https://www.nature.com/articles/nrgastro.2011.81
    147 sgo:license sg:explorer/license/
    148 sgo:sdDataset articles
    149 rdf:type schema:ScholarlyArticle
    150 N1282506ff55e4a128ed4b8285e7d3f67 rdf:first sg:person.01305062713.70
    151 rdf:rest Nbd9e8a007cc645eea6860be50470729b
    152 N134de91d1038472797d7181d1b0996ab schema:issueNumber 7
    153 rdf:type schema:PublicationIssue
    154 N146093594e8540d4b90388e4fc0218ac schema:volumeNumber 8
    155 rdf:type schema:PublicationVolume
    156 N2107abd822c544d68eff6adc4f4ea656 rdf:first sg:person.01012133613.37
    157 rdf:rest N4da898b7cee74b9e97b9b060a5092249
    158 N30fcfec2893f437ab19ef29d48b302a2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    159 schema:name Receptor, ErbB-2
    160 rdf:type schema:DefinedTerm
    161 N331821cfccf04124b36084bcdf39e1bb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    162 schema:name Treatment Outcome
    163 rdf:type schema:DefinedTerm
    164 N4968163de3fa4b99afa95673677ae36d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    165 schema:name Humans
    166 rdf:type schema:DefinedTerm
    167 N4da898b7cee74b9e97b9b060a5092249 rdf:first sg:person.01006607213.66
    168 rdf:rest Ncf91d3f41e5c4936adebfb5b60f6f95b
    169 N54a384b70cb64796b2420f1ccdcc1d86 schema:name doi
    170 schema:value 10.1038/nrgastro.2011.81
    171 rdf:type schema:PropertyValue
    172 N5b69a632ff144f79ab8f7378208cbad4 schema:name readcube_id
    173 schema:value 0372f27d08e98bd0645bdc67da72d2a2fc93f91531c87853094c59681199fe4b
    174 rdf:type schema:PropertyValue
    175 N867696c7f57d4e81b5b754be14583577 schema:name Springer Nature - SN SciGraph project
    176 rdf:type schema:Organization
    177 N9313154538394c52bc45b9c34c23178e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    178 schema:name Esophageal Neoplasms
    179 rdf:type schema:DefinedTerm
    180 N968dccc49cc44e1db7ba45cccd3dca55 schema:name dimensions_id
    181 schema:value pub.1000724233
    182 rdf:type schema:PropertyValue
    183 N9bddf06bb1b146599bd7a16d7ff3ff95 rdf:first sg:person.01164506727.84
    184 rdf:rest Nff60e39389ff4c22a96f136125708336
    185 Nb2f53d870d3b4fa7b96b3998125c2556 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    186 schema:name Receptor, Epidermal Growth Factor
    187 rdf:type schema:DefinedTerm
    188 Nb67b27f8f2df4b54887145784e7e5c53 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    189 schema:name Esophagogastric Junction
    190 rdf:type schema:DefinedTerm
    191 Nb7848239586d4f1f92a87e12c896b0aa schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    192 schema:name Antineoplastic Agents
    193 rdf:type schema:DefinedTerm
    194 Nba2cd780d18b413a85c4857da651830e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    195 schema:name Antibodies, Monoclonal
    196 rdf:type schema:DefinedTerm
    197 Nbb6f47c69c454560bc3acf67593f0559 rdf:first sg:person.01006230145.44
    198 rdf:rest rdf:nil
    199 Nbd9e8a007cc645eea6860be50470729b rdf:first sg:person.01062670207.83
    200 rdf:rest Nbb6f47c69c454560bc3acf67593f0559
    201 Ncf91d3f41e5c4936adebfb5b60f6f95b rdf:first sg:person.01170634313.13
    202 rdf:rest N1282506ff55e4a128ed4b8285e7d3f67
    203 Ne360c68bc62145078192bea63f03aaea schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    204 schema:name Stomach Neoplasms
    205 rdf:type schema:DefinedTerm
    206 Ne50b93d6f267436899c1d35d6d76f206 schema:name pubmed_id
    207 schema:value 21647199
    208 rdf:type schema:PropertyValue
    209 Nf6f7fc439d8e428d936e1b211d6784c2 schema:name nlm_unique_id
    210 schema:value 101500079
    211 rdf:type schema:PropertyValue
    212 Nff60e39389ff4c22a96f136125708336 rdf:first sg:person.01165207053.41
    213 rdf:rest N2107abd822c544d68eff6adc4f4ea656
    214 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    215 schema:name Medical and Health Sciences
    216 rdf:type schema:DefinedTerm
    217 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
    218 schema:name Oncology and Carcinogenesis
    219 rdf:type schema:DefinedTerm
    220 sg:journal.1294865 schema:issn 1759-5045
    221 1759-5053
    222 schema:name Nature Reviews Gastroenterology & Hepatology
    223 rdf:type schema:Periodical
    224 sg:person.01006230145.44 schema:affiliation https://www.grid.ac/institutes/grid.144189.1
    225 schema:familyName Falcone
    226 schema:givenName Alfredo
    227 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01006230145.44
    228 rdf:type schema:Person
    229 sg:person.01006607213.66 schema:affiliation https://www.grid.ac/institutes/grid.144189.1
    230 schema:familyName Vasile
    231 schema:givenName Enrico
    232 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01006607213.66
    233 rdf:type schema:Person
    234 sg:person.01012133613.37 schema:affiliation https://www.grid.ac/institutes/grid.144189.1
    235 schema:familyName Caparello
    236 schema:givenName Chiara
    237 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01012133613.37
    238 rdf:type schema:Person
    239 sg:person.01062670207.83 schema:affiliation https://www.grid.ac/institutes/grid.144189.1
    240 schema:familyName Masi
    241 schema:givenName Gianluca
    242 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01062670207.83
    243 rdf:type schema:Person
    244 sg:person.01164506727.84 schema:affiliation https://www.grid.ac/institutes/grid.144189.1
    245 schema:familyName Fornaro
    246 schema:givenName Lorenzo
    247 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01164506727.84
    248 rdf:type schema:Person
    249 sg:person.01165207053.41 schema:affiliation https://www.grid.ac/institutes/grid.144189.1
    250 schema:familyName Lucchesi
    251 schema:givenName Maurizio
    252 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01165207053.41
    253 rdf:type schema:Person
    254 sg:person.01170634313.13 schema:affiliation https://www.grid.ac/institutes/grid.144189.1
    255 schema:familyName Caponi
    256 schema:givenName Sara
    257 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01170634313.13
    258 rdf:type schema:Person
    259 sg:person.01305062713.70 schema:affiliation https://www.grid.ac/institutes/grid.144189.1
    260 schema:familyName Ginocchi
    261 schema:givenName Laura
    262 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01305062713.70
    263 rdf:type schema:Person
    264 sg:pub.10.1007/s00262-005-0058-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1038243318
    265 https://doi.org/10.1007/s00262-005-0058-x
    266 rdf:type schema:CreativeWork
    267 sg:pub.10.1007/s00280-009-1067-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018932393
    268 https://doi.org/10.1007/s00280-009-1067-9
    269 rdf:type schema:CreativeWork
    270 sg:pub.10.1007/s00428-010-0952-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008262506
    271 https://doi.org/10.1007/s00428-010-0952-2
    272 rdf:type schema:CreativeWork
    273 sg:pub.10.1007/s10637-009-9363-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046585078
    274 https://doi.org/10.1007/s10637-009-9363-0
    275 rdf:type schema:CreativeWork
    276 sg:pub.10.1007/s11912-010-0137-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024155571
    277 https://doi.org/10.1007/s11912-010-0137-9
    278 rdf:type schema:CreativeWork
    279 sg:pub.10.1038/418934a schema:sameAs https://app.dimensions.ai/details/publication/pub.1042017236
    280 https://doi.org/10.1038/418934a
    281 rdf:type schema:CreativeWork
    282 sg:pub.10.1038/bjc.2012.47 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030389345
    283 https://doi.org/10.1038/bjc.2012.47
    284 rdf:type schema:CreativeWork
    285 sg:pub.10.1038/modpathol.3800085 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041581944
    286 https://doi.org/10.1038/modpathol.3800085
    287 rdf:type schema:CreativeWork
    288 sg:pub.10.1038/modpathol.3880007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011441671
    289 https://doi.org/10.1038/modpathol.3880007
    290 rdf:type schema:CreativeWork
    291 sg:pub.10.1038/nrc2088 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032628685
    292 https://doi.org/10.1038/nrc2088
    293 rdf:type schema:CreativeWork
    294 sg:pub.10.1038/nrclinonc.2009.111 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007415410
    295 https://doi.org/10.1038/nrclinonc.2009.111
    296 rdf:type schema:CreativeWork
    297 sg:pub.10.1038/nrclinonc.2009.216 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049327283
    298 https://doi.org/10.1038/nrclinonc.2009.216
    299 rdf:type schema:CreativeWork
    300 sg:pub.10.1038/sj.bjc.6603459 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045932147
    301 https://doi.org/10.1038/sj.bjc.6603459
    302 rdf:type schema:CreativeWork
    303 sg:pub.10.1038/sj.bjc.6604211 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035664868
    304 https://doi.org/10.1038/sj.bjc.6604211
    305 rdf:type schema:CreativeWork
    306 sg:pub.10.1038/sj.bjc.6604861 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004443137
    307 https://doi.org/10.1038/sj.bjc.6604861
    308 rdf:type schema:CreativeWork
    309 sg:pub.10.1038/sj.bjc.6605319 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010815314
    310 https://doi.org/10.1038/sj.bjc.6605319
    311 rdf:type schema:CreativeWork
    312 sg:pub.10.1038/sj.bjc.6605521 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003673412
    313 https://doi.org/10.1038/sj.bjc.6605521
    314 rdf:type schema:CreativeWork
    315 sg:pub.10.1038/sj.onc.1206749 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018108900
    316 https://doi.org/10.1038/sj.onc.1206749
    317 rdf:type schema:CreativeWork
    318 sg:pub.10.1038/sj.onc.1207061 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030493697
    319 https://doi.org/10.1038/sj.onc.1207061
    320 rdf:type schema:CreativeWork
    321 sg:pub.10.1245/s10434-007-9596-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018777047
    322 https://doi.org/10.1245/s10434-007-9596-0
    323 rdf:type schema:CreativeWork
    324 https://app.dimensions.ai/details/publication/pub.1074779314 schema:CreativeWork
    325 https://app.dimensions.ai/details/publication/pub.1075274588 schema:CreativeWork
    326 https://app.dimensions.ai/details/publication/pub.1077243466 schema:CreativeWork
    327 https://app.dimensions.ai/details/publication/pub.1078292383 schema:CreativeWork
    328 https://app.dimensions.ai/details/publication/pub.1082504447 schema:CreativeWork
    329 https://doi.org/10.1002/(sici)1521-1878(199801)20:1<41::aid-bies7>3.0.co;2-v schema:sameAs https://app.dimensions.ai/details/publication/pub.1013765345
    330 rdf:type schema:CreativeWork
    331 https://doi.org/10.1002/1097-0142(19950315)75:6+<1418::aid-cncr2820751505>3.0.co;2-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1011117491
    332 rdf:type schema:CreativeWork
    333 https://doi.org/10.1002/1097-0142(19950615)75:12<2794::aid-cncr2820751203>3.0.co;2-f schema:sameAs https://app.dimensions.ai/details/publication/pub.1010985497
    334 rdf:type schema:CreativeWork
    335 https://doi.org/10.1002/ijc.11553 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002458841
    336 rdf:type schema:CreativeWork
    337 https://doi.org/10.1002/path.971 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017034982
    338 rdf:type schema:CreativeWork
    339 https://doi.org/10.1016/0016-5085(90)90019-w schema:sameAs https://app.dimensions.ai/details/publication/pub.1054543859
    340 rdf:type schema:CreativeWork
    341 https://doi.org/10.1016/j.ccr.2004.06.022 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016986102
    342 rdf:type schema:CreativeWork
    343 https://doi.org/10.1016/j.ccr.2007.08.030 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034133737
    344 rdf:type schema:CreativeWork
    345 https://doi.org/10.1016/j.critrevonc.2009.01.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048746404
    346 rdf:type schema:CreativeWork
    347 https://doi.org/10.1016/j.ctrv.2009.04.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033676438
    348 rdf:type schema:CreativeWork
    349 https://doi.org/10.1016/j.ctrv.2009.12.009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049783583
    350 rdf:type schema:CreativeWork
    351 https://doi.org/10.1016/j.ctrv.2010.01.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023167426
    352 rdf:type schema:CreativeWork
    353 https://doi.org/10.1016/j.ejca.2010.03.017 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037548521
    354 rdf:type schema:CreativeWork
    355 https://doi.org/10.1016/j.ejca.2010.05.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052132896
    356 rdf:type schema:CreativeWork
    357 https://doi.org/10.1016/j.yexcr.2004.12.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031908758
    358 rdf:type schema:CreativeWork
    359 https://doi.org/10.1016/s0065-230x(09)02002-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047562265
    360 rdf:type schema:CreativeWork
    361 https://doi.org/10.1016/s0140-6736(09)60569-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026273347
    362 rdf:type schema:CreativeWork
    363 https://doi.org/10.1016/s0140-6736(10)61121-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1044182432
    364 rdf:type schema:CreativeWork
    365 https://doi.org/10.1016/s0305-7372(10)70002-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043341479
    366 rdf:type schema:CreativeWork
    367 https://doi.org/10.1016/s0305-7372(10)70014-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015992849
    368 rdf:type schema:CreativeWork
    369 https://doi.org/10.1016/s0959-8049(01)00230-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033094712
    370 rdf:type schema:CreativeWork
    371 https://doi.org/10.1016/s1359-6349(09)71233-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051623230
    372 rdf:type schema:CreativeWork
    373 https://doi.org/10.1016/s1470-2045(10)70125-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1038036425
    374 rdf:type schema:CreativeWork
    375 https://doi.org/10.1053/j.seminoncol.2004.04.021 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031576130
    376 rdf:type schema:CreativeWork
    377 https://doi.org/10.1056/nejmoa033025 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035161767
    378 rdf:type schema:CreativeWork
    379 https://doi.org/10.1056/nejmoa0802656 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031603011
    380 rdf:type schema:CreativeWork
    381 https://doi.org/10.1056/nejmoa0808268 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029533783
    382 rdf:type schema:CreativeWork
    383 https://doi.org/10.1074/jbc.274.19.13176 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052475518
    384 rdf:type schema:CreativeWork
    385 https://doi.org/10.1093/annonc/mdi064 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039835370
    386 rdf:type schema:CreativeWork
    387 https://doi.org/10.1093/annonc/mdl459 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043337256
    388 rdf:type schema:CreativeWork
    389 https://doi.org/10.1093/annonc/mdn169 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026667587
    390 rdf:type schema:CreativeWork
    391 https://doi.org/10.1093/annonc/mdq247 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004875896
    392 rdf:type schema:CreativeWork
    393 https://doi.org/10.1093/annonc/mdq591 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050287251
    394 rdf:type schema:CreativeWork
    395 https://doi.org/10.1093/annonc/mdq706 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039876871
    396 rdf:type schema:CreativeWork
    397 https://doi.org/10.1093/jnci/77.5.1047 schema:sameAs https://app.dimensions.ai/details/publication/pub.1079764985
    398 rdf:type schema:CreativeWork
    399 https://doi.org/10.1093/jnci/93.24.1852 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022747550
    400 rdf:type schema:CreativeWork
    401 https://doi.org/10.1093/jnci/djp280 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051366374
    402 rdf:type schema:CreativeWork
    403 https://doi.org/10.1097/01.cco.0000155059.39733.9d schema:sameAs https://app.dimensions.ai/details/publication/pub.1032911688
    404 rdf:type schema:CreativeWork
    405 https://doi.org/10.1111/j.1349-7006.2009.01447.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1001573295
    406 rdf:type schema:CreativeWork
    407 https://doi.org/10.1111/j.1365-2559.2008.03028.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1042540498
    408 rdf:type schema:CreativeWork
    409 https://doi.org/10.1111/j.1365-2559.2011.03760.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1046023288
    410 rdf:type schema:CreativeWork
    411 https://doi.org/10.1111/j.1365-3083.1994.tb03401.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1042091110
    412 rdf:type schema:CreativeWork
    413 https://doi.org/10.1158/0008-5472-can-04-3913 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011326721
    414 rdf:type schema:CreativeWork
    415 https://doi.org/10.1158/0008-5472.can-03-3856 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006401030
    416 rdf:type schema:CreativeWork
    417 https://doi.org/10.1158/0008-5472.can-06-2101 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018366044
    418 rdf:type schema:CreativeWork
    419 https://doi.org/10.1158/0008-5472.can-08-1740 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034617811
    420 rdf:type schema:CreativeWork
    421 https://doi.org/10.1158/0008-5472.can-08-4597 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053676255
    422 rdf:type schema:CreativeWork
    423 https://doi.org/10.1158/1078-0432.ccr-06-1304 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049548242
    424 rdf:type schema:CreativeWork
    425 https://doi.org/10.1158/1078-0432.ccr-07-5165 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006825659
    426 rdf:type schema:CreativeWork
    427 https://doi.org/10.1158/1078-0432.ccr-09-1112 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005686924
    428 rdf:type schema:CreativeWork
    429 https://doi.org/10.1159/000288295 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023747586
    430 rdf:type schema:CreativeWork
    431 https://doi.org/10.1172/jci36049 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040013987
    432 rdf:type schema:CreativeWork
    433 https://doi.org/10.1200/jco.2000.18.21.3651 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074719576
    434 rdf:type schema:CreativeWork
    435 https://doi.org/10.1200/jco.2001.19.2.354 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074768320
    436 rdf:type schema:CreativeWork
    437 https://doi.org/10.1200/jco.2005.02.4646 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049107817
    438 rdf:type schema:CreativeWork
    439 https://doi.org/10.1200/jco.2005.05.2308 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064204262
    440 rdf:type schema:CreativeWork
    441 https://doi.org/10.1200/jco.2006.07.1316 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024659261
    442 rdf:type schema:CreativeWork
    443 https://doi.org/10.1200/jco.2006.10.5437 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024397161
    444 rdf:type schema:CreativeWork
    445 https://doi.org/10.1200/jco.2007.12.4602 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029961377
    446 rdf:type schema:CreativeWork
    447 https://doi.org/10.1200/jco.2007.13.9949 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043392679
    448 rdf:type schema:CreativeWork
    449 https://doi.org/10.1200/jco.2008.19.8135 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046046620
    450 rdf:type schema:CreativeWork
    451 https://doi.org/10.1200/jco.2008.20.2796 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009529915
    452 rdf:type schema:CreativeWork
    453 https://doi.org/10.1200/jco.2008.21.3744 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013781784
    454 rdf:type schema:CreativeWork
    455 https://doi.org/10.1200/jco.2008.26.15_suppl.15554 schema:sameAs https://app.dimensions.ai/details/publication/pub.1079371013
    456 rdf:type schema:CreativeWork
    457 https://doi.org/10.1200/jco.2008.26.15_suppl.15587 schema:sameAs https://app.dimensions.ai/details/publication/pub.1079370865
    458 rdf:type schema:CreativeWork
    459 https://doi.org/10.1200/jco.2009.22.6605 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028158072
    460 rdf:type schema:CreativeWork
    461 https://doi.org/10.1200/jco.2009.23.3452 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047799543
    462 rdf:type schema:CreativeWork
    463 https://doi.org/10.1200/jco.2009.24.1661 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028339567
    464 rdf:type schema:CreativeWork
    465 https://doi.org/10.1200/jco.2009.24.2024 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001727306
    466 rdf:type schema:CreativeWork
    467 https://doi.org/10.1200/jco.2009.24.6116 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028622217
    468 rdf:type schema:CreativeWork
    469 https://doi.org/10.1200/jco.2009.24.8617 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028057056
    470 rdf:type schema:CreativeWork
    471 https://doi.org/10.1200/jco.2009.25.2890 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051122376
    472 rdf:type schema:CreativeWork
    473 https://doi.org/10.1200/jco.2009.25.8707 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007511412
    474 rdf:type schema:CreativeWork
    475 https://doi.org/10.1200/jco.2009.27.5388 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035845707
    476 rdf:type schema:CreativeWork
    477 https://doi.org/10.1200/jco.2010.28.15_suppl.4133 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083943272
    478 rdf:type schema:CreativeWork
    479 https://doi.org/10.1200/jco.2010.29.1807 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026214238
    480 rdf:type schema:CreativeWork
    481 https://doi.org/10.1200/jco.2010.29.2847 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000659580
    482 rdf:type schema:CreativeWork
    483 https://doi.org/10.1200/jco.2010.29.3407 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037902142
    484 rdf:type schema:CreativeWork
    485 https://doi.org/10.1200/jco.2010.32.9615 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052513014
    486 rdf:type schema:CreativeWork
    487 https://doi.org/10.1200/jco.2011.29.4_suppl.93 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083951832
    488 rdf:type schema:CreativeWork
    489 https://doi.org/10.1517/14656560903427997 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000911604
    490 rdf:type schema:CreativeWork
    491 https://doi.org/10.1634/theoncologist.2008-0181 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011763643
    492 rdf:type schema:CreativeWork
    493 https://doi.org/10.1634/theoncologist.8-suppl_3-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011456337
    494 rdf:type schema:CreativeWork
    495 https://doi.org/10.3233/clo-2009-0497 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034695709
    496 rdf:type schema:CreativeWork
    497 https://doi.org/10.3322/caac.20107 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009055747
    498 rdf:type schema:CreativeWork
    499 https://doi.org/10.3816/cbc.2008.n.047 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033182820
    500 rdf:type schema:CreativeWork
    501 https://doi.org/10.3892/or.15.1.65 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071529842
    502 rdf:type schema:CreativeWork
    503 https://www.grid.ac/institutes/grid.144189.1 schema:alternateName Azienda Ospedaliera Universitaria Pisana
    504 schema:name U.O. Oncologia Medica 2 Universitaria, Azienda Ospedaliero-Universitaria Pisana, Istituto Toscano-Tumori, Via Roma 67, 56126 Pisa, Italy
    505 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...