DNA Pooling: a tool for large-scale association studies View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2002-11

AUTHORS

Pak Sham, Joel S. Bader, Ian Craig, Michael O'Donovan, Michael Owen

ABSTRACT

DNA pooling is a practical way to reduce the cost of large-scale association studies to identify susceptibility loci for common diseases. Pooling allows allele frequencies in groups of individuals to be measured using far fewer PCR reactions and genotyping assays than are used when genotyping individuals. Here, we discuss recent developments in quantitative genotyping assays and in the design and analysis of pooling studies. Sophisticated pooling designs are being developed that can take account of hidden population stratification, confounders and inter-loci interactions, and that allow the analysis of haplotypes. More... »

PAGES

862

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nrg930

DOI

http://dx.doi.org/10.1038/nrg930

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1025109461

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/12415316


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