Gene silencing in mammals by small interfering RNAs View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2002-10

AUTHORS

Michael T. McManus, Phillip A. Sharp

ABSTRACT

Among the 3 billion base pairs of the human genome, there are approximately 30,000-40,000 protein-coding genes, but the function of at least half of them remains unknown. A new tool - short interfering RNAs (siRNAs) - has now been developed for systematically deciphering the functions and interactions of these thousands of genes. siRNAs are an intermediate of RNA interference, the process by which double-stranded RNA silences homologous genes. Although the use of siRNAs to silence genes in vertebrate cells was only reported a year ago, the emerging literature indicates that most vertebrate genes can be studied with this technology. More... »

PAGES

737-747

References to SciGraph publications

  • 2002-07. Modulation of HIV-1 replication by RNA interference in NATURE
  • 2001-05. Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells in NATURE
  • 2000-08. Heritable gene silencing in Drosophila using double-stranded RNA in NATURE BIOTECHNOLOGY
  • 2000-03. An RNA-directed nuclease mediates post-transcriptional gene silencing in Drosophila cells in NATURE
  • 2000-02. The 21-nucleotide let-7 RNA regulates developmental timing in Caenorhabditis elegans in NATURE
  • 2000-09. Gene expression: Total silencing by intron-spliced hairpin RNAs in NATURE
  • 2001-09. Control of developmental timing in animals in NATURE REVIEWS GENETICS
  • 1999-05. Gene silencing in Neurospora crassa requires a protein homologous to RNA-dependent RNA polymerase in NATURE
  • 2001-06. Role of PHABULOSA and PHAVOLUTA in determining radial patterning in shoots in NATURE
  • 2002-07. Gene expression: RNA interference in adult mice in NATURE
  • 2001-12. Phenotypic silencing of cytoplasmic genes using sequence-specific double-stranded short interfering RNA and its application in the reverse genetics of wild type negative-strand RNA viruses in BMC MICROBIOLOGY
  • 2002-04. Deregulated human Cdc14A phosphatase disrupts centrosome separation and chromosome segregation in NATURE CELL BIOLOGY
  • 2000-02. Heritable and inducible genetic interference by double-stranded RNA encoded by transgenes in NATURE GENETICS
  • 1998-02. Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans in NATURE
  • 2001-11. A multiprotein complex mediates the ATP-dependent assembly of spliceosomal U snRNPs in NATURE CELL BIOLOGY
  • 2002-05. Effective expression of small interfering RNA in human cells in NATURE BIOTECHNOLOGY
  • 2002-05. Expression of small interfering RNAs targeted against HIV-1 rev transcripts in human cells in NATURE BIOTECHNOLOGY
  • 2002-09. Efficient delivery of siRNA for inhibition of gene expression in postnatal mice in NATURE GENETICS
  • 2002-07. siRNA-directed inhibition of HIV-1 infection in NATURE MEDICINE
  • 2002-01. The exocyst is a Ral effector complex in NATURE CELL BIOLOGY
  • 2000-04. Induction of apoptosis by the dsRNA-dependent protein kinase (PKR): Mechanism of action in APOPTOSIS
  • 2001-06. Gene silencing as an adaptive defence against viruses in NATURE
  • 2000-11. Conservation of the sequence and temporal expression of let-7 heterochronic regulatory RNA in NATURE
  • 2002-07. Short interfering RNA confers intracellular antiviral immunity in human cells in NATURE
  • 2001-01. Role for a bidentate ribonuclease in the initiation step of RNA interference in NATURE
  • 2002-05. U6 promoter–driven siRNAs with four uridine 3′ overhangs efficiently suppress targeted gene expression in mammalian cells in NATURE BIOTECHNOLOGY
  • Journal

    TITLE

    Nature Reviews Genetics

    ISSUE

    10

    VOLUME

    3

    Related Patents

  • Immune-Compromised Transgenic Mice Expressing Human Hepatocyte Growth Factor (Hhgf)
  • Compositions, Devices And Methods For Treatment Of Huntington's Disease Through Intracranial Delivery Of Sirna
  • Selective Histamine H4 Receptor Antagonists For The Treatment Of Vestibular Disorders.
  • Method And Medicament For Inhibiting The Expression Of A Given Gene
  • Methods And Compositions For Enhancing The Efficacy And Specificity Of Rna Silencing
  • Method Of Regulating Gene Expression
  • Orthotopic And Genetically Tractable Non-Human Animal Model For Liver Cancer And The Uses Thereof
  • Oligoribonucleotides And Methods Of Use Thereof For Treatment Of Fibrotic Conditions And Other Diseases
  • Sirna Compounds For Inhibiting Nrf2
  • Method And Medicament For Inhibiting The Expression Of A Given Gene
  • Method And Medicament For Inhibiting The Expression Of A Given Gene
  • Treatment Of Viral Infections By Modulation Of Host Cell Metabolic Pathways
  • Delivering Functional Nucleic Acids To Mammalian Cells Via Bacterially-Derived, Intact Minicells
  • Control Of Gene Expression
  • Methods And Compositions For Enhancing The Efficacy And Specificity Of Single And Double Blunt-Ended Sirna
  • Antisense Oligomers Targeting Pcsk9
  • Plant Cell Signaling Genes
  • Methods For Cancer Management Targeting Co-029
  • Bacterially Derived Intact Minicells That Encompass Plasmid Free Functional Nucleic Acid For In Vivo Delivery To Mammalian Cells
  • In Vivo Production Of Small Interfering Rnas That Mediate Gene Silencing
  • Therapeutic Uses Of Inhibitors Of Rtp801l
  • Nucleic Acid Functionalized Nanoparticles For Therapeutic Applications
  • Methods And Compositions For Vitamin K Epoxide Reductase
  • Methods And Compositions For The Specific Inhibition Of Gene Expression By Double-Stranded Rna
  • Cancer Immunotherapy
  • Cancer Therapy
  • Susceptibility Variants For Peripheral Arterial Disease And Abdominal Aortic Aneurysm
  • Methods And Systems For Converting Precursor Cells Into Intestinal Tissues Through Directed Differentiation
  • Nucleic Acid Functionalized Nonoparticles For Therapeutic Applications
  • Method And Medicament For Inhibiting The Expression Of A Given Gene
  • Treatment Of Neurodegenerative Disease Through Intracranial Delivery Of Sirna
  • Combination Therapy For Treating Hearing And Balance Disorders
  • Method And Medicament For Inhibiting The Expression Of A Given Gene
  • Therapeutic Alteration Of Transplantable Tissues Through In Situ Or Ex Vivo Exposure To Rna Interference Molecules
  • Synthetic Genes And Genetic Constructs
  • Therapeutic Alteration Of Transplantable Tissues Through In Situ Or Ex Vivo Exposure To Rna Interference Molecules
  • Rna Interference For The Treatment Of Gain-Of-Function Disorders
  • Sodium Channel Protein Type Iii Α-Subunit Splice Variant
  • Methods And Compositions For Producing Vitamin K Dependent Proteins
  • Sirna-Mediated Gene Silencing
  • Methods And Compositions For Enhancing The Efficacy And Specificity Of Rna Silencing
  • Agents And Methods To Elicit Anti-Tumor Immune Response
  • Methods And Compositions For The Specific Inhibition Of Gene Expression By Double-Stranded Rna
  • Markers For Breast Cancer
  • Composition And Method For In Vivo And In Vitro Attenuation Of Gene Expression Using Double Stranded Rna
  • Sodium Channel Protein Type Iii Α-Subunit Splice Variant
  • Identification And Use Of Target Genes For Control Of Plant Parasitic Nematodes
  • Sirna Compounds Comprising Terminal Substitutions
  • Personal-Care Articles Having Self-Assembling Peptides
  • Sirna-Mediated Gene Silencing Of Synuclein
  • Methods And Compositions For Vitamin K Epoxide Reductase
  • Oligonucleotide Conjugates
  • Short Interfering Rna (Sirna) Analogues
  • Inhibitors Of Rtp801 And Their Use In Disease Treatment
  • In Vivo Production Of Small Interfering Rnas That Mediate Gene Silencing
  • Methods For Genetic Control Of Plant Pest Infestation And Compositions Thereof
  • Treatment Of Neurodegenerative Disease Through Intracranial Delivery Of Sirna
  • Tetrodotoxin-Resistant Sodium Channel Alpha Subunit
  • Double-Stranded Oligonucleotides
  • Allele-Specific Rna Interference
  • Methods And Compositions For Enhancing The Efficacy And Specificity Of Rnai
  • Oligonucleotide Complex Compositions And Methods Of Use As Gene Alteration Tools
  • Composition Of Anti-Endo180 Antibodies And Methods Of Use For The Treatment Of Cancer And Fibrotic Diseases
  • Rna Sequence-Specific Mediators Of Rna Interference
  • Alternative Export Pathways For Vector Expressed Rna Interference
  • Identification And Use Of Target Genes For Control Of Plant Parasitic Nematodes
  • Methods And Compositions For The Specific Inhibition Of Gene Expression By Double-Stranded Rna
  • Oligonucleotide Compositions With Enhanced Efficiency
  • Sirna Compounds Comprising Terminal Substitutions
  • Oligoribonucleotides And Methods Of Use Thereof For Treatment Of Alopecia, Acute Renal Failure And Other Diseases
  • Method For Selecting Sirnas From A Plurality Of Sirnas For Gene Silencing
  • Antisense Oligonucleotides For Inhibition Of Microrna-21
  • Modulators Of Intracellular Chloride Concentration For Treating Down Syndrome
  • Oligonucleotide Compositions With Enhanced Efficiency
  • High Throughput Assay For Cancer Cell Growth Inhibition
  • Therapeutic Uses Of Inhibitors Of Rtp801
  • Methods And Compositions For Enhancing The Efficacy And Specificity Of Rna Silencing
  • Oligonucleotide Compounds Comprising Non-Nucleotide Overhangs
  • Markers For Pre-Cancer And Cancer Cells And The Method To Interfere With Cell Proliferation Therein
  • Interfering Rna Molecules
  • Markers For Pre-Cancer And Cancer Cells And The Method To Interfere With Cell Proliferation Therein
  • Micrornas
  • Method Of Treating A Metabolic Disorder Induced By Obesity In A Subject In Need Thereof By Administering Mk2/3 Inhibitors
  • Alternative Export Pathways For Vector Expressed Rna Interference
  • Delivering Functional Nucleic Acids To Mammalian Cells Via Bacterially-Derived, Intact Minicells
  • Identification And Use Of Target Genes For Control Of Plant Parasitic Nematodes
  • Oligonucleotide Compounds Comprising Non-Nucleotide Overhangs
  • Nanoconjugates Able To Cross The Blood-Brain Barrier
  • Templated Nanoconjugates
  • Compositions And Methods For Functional Nucleic Acid Delivery
  • Combination Treatment For The Treatment Of Hepatitis C Virus Infection
  • Multicistronic Constructs With Sirna To Inhibit Tumors
  • Interfering Rna Molecules
  • Vitamin K Epoxide Recycling Polypeptide Vkorc1, A Therapeutic Target Of Coumarin And Their Derivatives
  • Methods And Compositions For Vitamin K Epoxide Reductase
  • High Throughput Assay For Cancer Cell Growth Inhibition
  • Novel Synthesis Of Nucleoside 5'-Triphosphates And Their Derivatives
  • Compositions And Methods For Inhibiting Expression Of Anti-Apoptotic Genes
  • Nucleic Acid Cancer Immunotherapy
  • Methods And Compositions For Enhancing The Efficacy And Specificity Of Rna Silencing
  • Vascular Therapeutics
  • Method Of Regulating Gene Expression
  • Pharmaceutical Composition Comprising Anti-Mirna Antisense Oligonucleotide
  • Oligonucleotide Complex Compositions And Methods Of Use As Gene Alteration Tools
  • Methods For Genetic Control Of Plant Pest Infestation And Compositions Thereof
  • Composition Of Anti-Endo180 Antibodies And Methods Of Use For The Treatment Of Cancer And Fibrotic Diseases
  • Methods For Increasing Immune Responses Using Agents That Directly Bind To And Activate Ire-1
  • Methods And Means For Obtaining Modified Phenotypes
  • Multicistronic Constructs With Sirna To Inhibit Tumors
  • Interfering Rna Molecules
  • Compositions And Methods For Inhibiting Expression Of Anti-Apoptotic Genes
  • Vitamin K Epoxide Recycling Polypeptide Vkorc1, A Therapeutic Target Of Coumarin And Their Derivatives
  • Methods And Compositions For The Correlation Of Single Nucleotide Polymorphisms In The Vitamin K Epoxide Reductase Gene And Warfarin Dosage
  • Method And Medicament For Inhibiting The Expression Of A Given Gene
  • Methods Of Treating Eye Diseases In Diabetic Patients
  • Nucleic Acid Cancer Immunotherapy
  • Methods And Compositions For Vitamin K Epoxide Reductase
  • Methods And Compositions For Enhancing The Efficacy And Specificity Of Rna Silencing
  • Cxcl4l1 As A Biomarker Of Pancreatic Cancer
  • Control Of Gene Expression
  • Multicistronic Sirna Constructs To Inhibit Tumors
  • High Throughput Assay For Cancer Cell Growth Inhibition
  • Novel Synthesis Of Nucleoside 5'-Triphosphates And Their Derivatives
  • Particles For Detecting Intracellular Targets
  • Rna Interference Mediating Small Rna Molecules
  • Interfering Rna Molecules
  • Compositions And Methods For Reducing Or Protecting Against Delayed Graft Function (Dgf)
  • Bacterially Derived, Intact Minicells Encompassing Regulatory Rna
  • Treatment Of Viral Infections By Modulation Of Host Cell Metabolic Pathways
  • Methods And Compositions For Rna Interference
  • Methods And Compositions For Producing Active Vitamin K-Dependent Proteins
  • Oligonucleotide Modulators Of The Toll-Like Receptor Pathway
  • Methods And Compositions For The Specific Inhibition Of Gene Expression By Double-Stranded Rna
  • Double-Stranded Oligonucleotides
  • Micro-Rna Mediated Modulation Of Colony Stimulating Factors
  • Methods And Compositions For The Specific Inhibition Of Gene Expression By Double-Stranded Rna
  • Genetic Markers Associated With Risk Of Diabetes Mellitus
  • Interfering Rna Molecules
  • Differentially Expressed Genes In Large Granular Lymphocyte Leukemia
  • Markers For Pre-Cancer And Cancer Cells And The Method To Interfere With Cell Proliferation Therein
  • Treatment Of Viral Infections By Modulation Of Host Cell Metabolic Pathways
  • Bacterially Derived Intact Minicells That Encompass Plasmid Free Functional Nucleic Acid For In Vivo Delivery To Mammalian Cells
  • Methods And Compositions For Producing Vitamin K Dependent Proteins
  • Method Of Preparing Composition For Delivering An Anionic Drug
  • Methods And Compositions For The Specific Inhibition Of Gene Expression By Double-Stranded Rna
  • Genetic Variants On Chr 5p12 And 10q26 As Markers For Use In Breast Cancer Risk Assessment, Diagnosis, Prognosis And Treatment
  • Rna Sequence-Specific Mediators Of Rna Interference
  • Methods And Compositions For Rna Interference
  • Interfering Rna Molecules
  • Polyvalent Rna-Nanoparticle Compositions
  • Devices, Systems And Methods For Improving Memory And/Or Cognitive Function Through Brain Delivery Of Sirna
  • Synthetic Genes And Genetic Constructs
  • Compounds For Inducing Anti-Tumor Immunity And Methods Thereof
  • Short Interfering Rna (Sirna) Analogues
  • Micromirs
  • Treatment Or Prevention Of Oto-Pathologies By Inhibition Of Pro-Apoptotic Genes
  • Pharmaceutical Compositions For Treatment Of Microrna Related Diseases
  • Methods For Delivery Of Sirna To The Spinal Cord And Therapies Arising Therefrom
  • Synthetic Genes And Genetic Constructs Comprising Same I
  • Interfering Rna Molecules
  • Oligoribonucleotides And Methods Of Use Thereof For Treatment Of Fibrotic Conditions And Other Diseases
  • Method Of Designing Sirnas For Gene Silencing
  • Personal-Care Articles Having Self-Assembling Peptides
  • Prevention And Treatment Of Acute Renal Failure And Other Kidney Diseases By Inhibition Of P53 By Sirna
  • Allele-Specific Rna Interference
  • Small Interference Rna Gene Therapy
  • Methods Of Treatment Of Acute Renal Failure
  • Self-Assembling Peptides For Regeneration And Repair Of Neural Tissue
  • Cellulose Synthase From Pine And Methods Of Use
  • Methods And Compositions For Treating Neurological Disease
  • Disruption Of Acc Synthase Genes To Delay Senescence In Plants
  • Nucleic Acid Functionalized Nanoparticles For Therapeutic Applications
  • Methods And Compositions For Rna Interference
  • Catecholic Butanes And Use Thereof For Cancer Therapy
  • Bacterially Derived, Intact Minicells Encompassing Regulatory Rna
  • Rna Interference Mediating Small Rna Molecules
  • Methods And Compositions For The Specific Inhibition Of Gene Expression By Double-Stranded Rna
  • Interfering Rna Molecules
  • Pharmaceutical Compositions For Treatment Of Microrna Related Diseases
  • Therapeutic Alteration Of Transplantable Tissues Through In Situ Or Ex Vivo Exposure To Rna Interference Molecules
  • Nucleic Acid Functionalized Nanoparticles For Therapeutic Applications
  • Genetic Variants Contributing To Risk Of Prostate Cancer
  • Rna Interference Mediating Small Rna Molecules
  • Genetic Markers For Risk Management Of Atrial Fibrillation And Stroke
  • Compositions For Rna Interference And Methods Of Use Thereof
  • Mzb1, A Novel B Cell Factor, And Uses Thereof
  • Short Interfering Rna (Sirna) Analogues
  • Methods Of Treating Ischemia-Reperfusion Injury With Sirnas
  • Methods And Compositions For Vitamin K Epoxide Reductase
  • Control Of Gene Expression
  • High Potency Sirnas For Reducing The Expression Of Target Genes
  • Use Of A Decoy Protein That Interferes With The Hedgehog Signalling Pathway For The Manufacture Of A Medicament For Preventing, Inhibiting, And/Or Reversing Ocular Diseases Related With Ocular Neovascularization
  • Synthetic Genes And Genetic Constructs
  • Markers For Breast Cancer
  • Methods Of Treating A Meiotic Kinesin Associated Disease
  • Bacterially-Derived, Intact Minicells That Encompass Plasmid-Free Functional Nucleic Acid For In Vivo Delivery To Mammalian Cells
  • Methods And Compositions For The Specific Inhibition Of Gene Expression By Double-Stranded Rna
  • Oligomeric Compounds And Compositions For Use In Modulation Of Mirnas
  • Methods And Means For Obtaining Modified Phenotypes
  • Interfering Rna Molecules
  • Oligomeric Compounds And Compositions For Use In Modulation Of Mirnas
  • Methods And Compositions For Enhancing The Efficacy And Specificity Of Rna Silencing
  • Therapeutic Uses Of Inhibitors Of Rtp801
  • Inhibition Of Autophagy Genes In Cancer Chemotherapy
  • Inhibition Of Cancer Metastasis
  • Method For Making A 21 Nucleotide Double Stranded Rna Chemically Linked At One End
  • Synthetic Genes And Genetic Constructs
  • Polynucleotides Encoding Cellulose Synthase From Pinus Radiata And Methods Of Use For Regulating Polysaccharides Of A Plant
  • Method And Medicament For Inhibiting The Expression Of A Given Gene
  • Method And Medicament For Inhibiting The Expression Of A Given Gene
  • Short Oligomer Antagonist Compounds For The Modulation Of Target Mrna
  • Agent For Targeting C-Jun Mrna
  • Sirna Compositions Promoting Scar-Free Wound Healing Of Skin And Methods For Wound Treatment
  • Alternative Export Pathways For Vector Expressed Rna Interference
  • Oligonucleotide Compositions With Enhanced Efficiency
  • Agents And Methods To Elicit Anti-Tumor Immune Response
  • Method And Medicament For Inhibiting The Expression Of A Given Gene
  • Methods And Compositions For Producing Vitamin K Dependent Proteins
  • Methods For Diagnosing And Treating Oncogenic Kras-Associated Cancer
  • Methods Of Treating A Meiotic Kinesin-Associated Disease
  • Sirna-Mediated Gene Silencing
  • Polyvalent Rna-Nanoparticle Compositions
  • Devices, Systems And Methods For Improving Memory And/Or Cognitive Function Through Brain Delivery Of Sirna
  • Method Of Regulating Gene Expression
  • Methods And Compositions For Rna Interference
  • Susceptibility Variants For Lung Cancer
  • Pharmaceutical Compositions For Treatment Of Hcv Patients That Are Poor-Responders To Interferon
  • Therapeutic Uses Of Inhibitors Of Rtp801
  • Genetic Susceptibility Variants Associated With Cardiovascular Disease
  • Methods And Means For Producing Barley Yellow Dwarf Virus Resistant Cereal Plants
  • Inducible Small Interfering Rna (Sirna) Expression Constructs For Targeted Gene Silencing
  • Composition And Method For In Vivo And In Vitro Attenuation Of Gene Expression Using Double Stranded Rna
  • Treatment Or Prevention Of Oto-Pathologies By Inhibition Of Pro-Apoptotic Genes
  • Vitamin K Epoxide Recycling Polypeptide Vkorc1, A Therapeutic Target Of Coumarin And Their Derivatives
  • Histamine H4 Receptor Antagonists For The Treatment Of Vestibular Disorders
  • Compositions And Methods For Inhibiting Expression Of Anti-Apoptotic Genes
  • Therapeutic Uses Of Inhibitors Of Rtp801
  • Plant Cell Signaling Genes
  • Methods And Compositions For Producing Active Vitamin K-Dependent Proteins
  • Synthesis Of Inhibitors Of P90rsk
  • Virally-Encoded Rnas As Substrates, Inhibitors And Delivery Vehicles For Rnai
  • Therapeutic Uses Of Inhibitors Of Rtp801l
  • Genetic Variants For Breast Cancer Risk Assessment
  • Sirna-Mediated Gene Silencing
  • Double-Stranded Rna Directed To Casp2 And Methods Of Use Thereof
  • Rtp801l Sirna Compounds And Methods Of Use Thereof
  • Method Of Regulating Gene Expression
  • Method And Medicament For Inhibiting The Expression Of A Given Gene
  • Oligoribonucleotides And Methods Of Use Thereof For Treatment Of Alopecia, Acute Renal Failure And Other Diseases
  • Particles For Detecting Intracellular Targets
  • Methods And Compositions For Rna Interference
  • Methods And Compositions For The Specific Inhibition Of Gene Expression By Double-Stranded Rna
  • Bacterially-Derived, Intact Minicells That Encompass Plasmid-Free Functional Nucleic Acid For In Vivo Delivery To Mammalian Cells
  • Cancer Therapy
  • Interfering Rna Molecules
  • Compositions For Rna Interference And Methods Of Use Thereof
  • Methods Of Inhibiting Smooth Muscle Cell Migration And Proliferation
  • Methods And Compositions For Vitamin K Epoxide Reductase
  • Rna Antagonist Compounds For The Inhibition Of Apo-B100 Expression
  • Rna Interference For The Treatment Of Gain-Of-Function Disorders
  • Selective Histamine H4 Receptor Antagonists For The Treatment Of Vestibular Disorders
  • Templated Nanoconjugates
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nrg908

    DOI

    http://dx.doi.org/10.1038/nrg908

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1003050911

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/12360232


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0604", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Genetics", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Biological Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Animals", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Gene Silencing", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Gene Targeting", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "MicroRNAs", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Molecular Sequence Data", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Nucleic Acid Conformation", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Plants", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "RNA, Messenger", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "RNA, Small Interfering", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Virus Diseases", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Massachusetts Institute of Technology", 
              "id": "https://www.grid.ac/institutes/grid.116068.8", 
              "name": [
                "Center for Cancer Research, Massachusetts Institute of Technology, 40 Ames Street E17-526, Cambridge, Massachusetts 02139, USA."
              ], 
              "type": "Organization"
            }, 
            "familyName": "McManus", 
            "givenName": "Michael T.", 
            "id": "sg:person.013543306317.34", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013543306317.34"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Massachusetts Institute of Technology", 
              "id": "https://www.grid.ac/institutes/grid.116068.8", 
              "name": [
                "Center for Cancer Research, Massachusetts Institute of Technology, 40 Ames Street E17-526, Cambridge, Massachusetts 02139, USA."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Sharp", 
            "givenName": "Phillip A.", 
            "id": "sg:person.01147001662.05", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01147001662.05"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1038/78531", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000314042", 
              "https://doi.org/10.1038/78531"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/78531", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000314042", 
              "https://doi.org/10.1038/78531"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncb777", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000490799", 
              "https://doi.org/10.1038/ncb777"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncb777", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000490799", 
              "https://doi.org/10.1038/ncb777"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nbt0502-497", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000546028", 
              "https://doi.org/10.1038/nbt0502-497"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nbt0502-497", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000546028", 
              "https://doi.org/10.1038/nbt0502-497"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/emboj/21.7.1723", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000915566"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gad.862301", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000961502"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncb1101-945", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001090536", 
              "https://doi.org/10.1038/ncb1101-945"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncb1101-945", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001090536", 
              "https://doi.org/10.1038/ncb1101-945"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1083/jcb.152.1.75", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001139584"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/nar/30.8.1757", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001204140"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1471-2180-1-34", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001533836", 
              "https://doi.org/10.1186/1471-2180-1-34"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/35088566", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001843561", 
              "https://doi.org/10.1038/35088566"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/35088566", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001843561", 
              "https://doi.org/10.1038/35088566"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0378-1119(00)00224-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002450910"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0092-8674(02)71133-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003818083"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/emboj/20.23.6877", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004775429"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1046-2023(02)00023-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004916138"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1046-2023(02)00023-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004916138"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.072190799", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004988443"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0092-8674(00)80368-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005088934"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0960-9822(00)00323-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005820102"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/418038a", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006471802", 
              "https://doi.org/10.1038/418038a"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/418038a", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006471802", 
              "https://doi.org/10.1038/418038a"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gad.927801", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006489317"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1046/j.1365-313x.1999.00431.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006718234"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/jvi.76.18.9225-9231.2002", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007665434"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1083/jcb.200108088", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008287619"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.082117599", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008914829"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm725", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010188992", 
              "https://doi.org/10.1038/nm725"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm725", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010188992", 
              "https://doi.org/10.1038/nm725"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.092143499", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011544791"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0960-9822(02)00975-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012430811"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0960-9822(02)00809-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012534253"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0092-8674(02)00863-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013070988"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.152327299", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013985622"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0092-8674(00)81644-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014004558"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/72850", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015018717", 
              "https://doi.org/10.1038/72850"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/72850", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015018717", 
              "https://doi.org/10.1038/72850"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1070948", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015520291"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature00873", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016155470", 
              "https://doi.org/10.1038/nature00873"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature00873", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016155470", 
              "https://doi.org/10.1038/nature00873"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m201503200", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016374367"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0960-9822(00)00528-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016508102"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nbt0502-500", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017195653", 
              "https://doi.org/10.1038/nbt0502-500"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nbt0502-500", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017195653", 
              "https://doi.org/10.1038/nbt0502-500"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gad.981002", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017530405"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.171251798", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017733703"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.97.7.3142", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017815429"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1006/mthe.2001.0481", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017946445"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/35888", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018713804", 
              "https://doi.org/10.1038/35888"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/35888", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018713804", 
              "https://doi.org/10.1038/35888"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.286.5441.950", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018807570"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1097-2765(02)00541-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019720069"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0092-8674(01)00576-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019924014"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/35030305", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020409977", 
              "https://doi.org/10.1038/35030305"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/35030305", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020409977", 
              "https://doi.org/10.1038/35030305"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1068999", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020993705"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0092-8674(01)00547-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021383396"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.032652399", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021560343"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1042/bj3630001", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022027741"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1042/bj3630001", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022027741"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1065062", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023084018"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0960-9822(00)00732-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023413773"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1064921", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023512870"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0092-8674(00)81906-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024442258"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gad.974702", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025305717"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1097-2765(02)00437-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027751467"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/35078107", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028423924", 
              "https://doi.org/10.1038/35078107"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/35078107", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028423924", 
              "https://doi.org/10.1038/35078107"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/emboj/20.24.7240", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029866593"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m106161200", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031330462"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0960-9822(01)00316-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031334372"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gad.950302", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031429267"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0092-8674(02)00908-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032329761"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/emboj/20.19.5443", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032445653"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nbt0502-505", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032921883", 
              "https://doi.org/10.1038/nbt0502-505"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nbt0502-505", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032921883", 
              "https://doi.org/10.1038/nbt0502-505"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1534-5807(01)00114-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033080869"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.94.25.13437", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034844741"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.060034297", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035793328"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0092-8674(00)80620-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035978762"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0092-8674(01)00431-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036555460"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gad.880001", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036718422"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1023/a:1009664109241", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037308227", 
              "https://doi.org/10.1023/a:1009664109241"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/20215", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038481561", 
              "https://doi.org/10.1038/20215"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/20215", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038481561", 
              "https://doi.org/10.1038/20215"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0092-8674(93)90530-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039515219"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/nar/30.10.e46", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041374327"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/35040556", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041493395", 
              "https://doi.org/10.1038/35040556"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/35040556", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041493395", 
              "https://doi.org/10.1038/35040556"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0092-8674(00)80864-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042263715"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng944", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042354461", 
              "https://doi.org/10.1038/ng944"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng944", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042354461", 
              "https://doi.org/10.1038/ng944"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/35053110", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042658253", 
              "https://doi.org/10.1038/35053110"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/35053110", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042658253", 
              "https://doi.org/10.1038/35053110"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1105/tpc.010358", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042690077"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncb728", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044541930", 
              "https://doi.org/10.1038/ncb728"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncb728", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044541930", 
              "https://doi.org/10.1038/ncb728"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/35079635", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044881407", 
              "https://doi.org/10.1038/35079635"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/35079635", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044881407", 
              "https://doi.org/10.1038/35079635"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1006/dbio.1999.9523", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045998074"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0092-8674(01)00506-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046862106"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/35002607", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047689840", 
              "https://doi.org/10.1038/35002607"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/35002607", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047689840", 
              "https://doi.org/10.1038/35002607"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1006/bbrc.2001.5707", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048647938"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1065329", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049696178"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1062961", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049854130"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature00896", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050512564", 
              "https://doi.org/10.1038/nature00896"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature00896", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050512564", 
              "https://doi.org/10.1038/nature00896"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1097-2765(00)00106-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050620574"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0092-8674(93)90529-y", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051619915"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1105/tpc.003210", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051968372"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/nar/26.22.5079", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052017314"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0960-9822(02)00665-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052166677"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/35081168", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052312028", 
              "https://doi.org/10.1038/35081168"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/35081168", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052312028", 
              "https://doi.org/10.1038/35081168"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/35081168", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052312028", 
              "https://doi.org/10.1038/35081168"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gad.1004402", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052409649"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/35005107", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053082190", 
              "https://doi.org/10.1038/35005107"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/35005107", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053082190", 
              "https://doi.org/10.1038/35005107"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.287.5462.2494", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053264156"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1017/s1355838202024032", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1054923777"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1042/0264-6021:3630001", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1056716070"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1062039", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062445158"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1064023", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062445376"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1073827", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062446723"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m107339200", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1074879749"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1074890809", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1074980687", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1078927779", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1080016070", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1083196589", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1083315631", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1083357043", 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2002-10", 
        "datePublishedReg": "2002-10-01", 
        "description": "Among the 3 billion base pairs of the human genome, there are approximately 30,000-40,000 protein-coding genes, but the function of at least half of them remains unknown. A new tool - short interfering RNAs (siRNAs) - has now been developed for systematically deciphering the functions and interactions of these thousands of genes. siRNAs are an intermediate of RNA interference, the process by which double-stranded RNA silences homologous genes. Although the use of siRNAs to silence genes in vertebrate cells was only reported a year ago, the emerging literature indicates that most vertebrate genes can be studied with this technology.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1038/nrg908", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": false, 
        "isPartOf": [
          {
            "id": "sg:journal.1023607", 
            "issn": [
              "1471-0056", 
              "1471-0064"
            ], 
            "name": "Nature Reviews Genetics", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "10", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "3"
          }
        ], 
        "name": "Gene silencing in mammals by small interfering RNAs", 
        "pagination": "737-747", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "0e885a19108c43427c5fa00be637656c0d184f4ab3daaaa7aec58b56a970fd61"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "12360232"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "100962779"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1038/nrg908"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1003050911"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1038/nrg908", 
          "https://app.dimensions.ai/details/publication/pub.1003050911"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-11T11:55", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000359_0000000359/records_29212_00000000.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "http://www.nature.com/articles/nrg908"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/nrg908'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/nrg908'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/nrg908'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/nrg908'


     

    This table displays all metadata directly associated to this object as RDF triples.

    466 TRIPLES      21 PREDICATES      149 URIs      32 LITERALS      20 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1038/nrg908 schema:about N05244e2b550540c6a11fb590a247e3f0
    2 N193f053d780b45d5a58e909846d897cd
    3 N230daa9f3320474c89c358cd295e9b06
    4 N2334e1fe104c4160b88ab9374892d9de
    5 N54a233151d9b4b76b53480c0648d8bf1
    6 Na4c2384ad2084beeb8c797853a215d74
    7 Nb20df21dd16046e4a232c6071506f72d
    8 Nbfc232c165f348fabf3d83483e5ca520
    9 Nc38d6fa9d377400bb24ac8515eebe60e
    10 Ndebabce22f8a4040ad9b749ec8bd83cb
    11 Nee9f065114014816b2d58c06428a0d46
    12 anzsrc-for:06
    13 anzsrc-for:0604
    14 schema:author N6470220cf024484f8c1b0e5d63915e5e
    15 schema:citation sg:pub.10.1023/a:1009664109241
    16 sg:pub.10.1038/20215
    17 sg:pub.10.1038/35002607
    18 sg:pub.10.1038/35005107
    19 sg:pub.10.1038/35030305
    20 sg:pub.10.1038/35040556
    21 sg:pub.10.1038/35053110
    22 sg:pub.10.1038/35078107
    23 sg:pub.10.1038/35079635
    24 sg:pub.10.1038/35081168
    25 sg:pub.10.1038/35088566
    26 sg:pub.10.1038/35888
    27 sg:pub.10.1038/418038a
    28 sg:pub.10.1038/72850
    29 sg:pub.10.1038/78531
    30 sg:pub.10.1038/nature00873
    31 sg:pub.10.1038/nature00896
    32 sg:pub.10.1038/nbt0502-497
    33 sg:pub.10.1038/nbt0502-500
    34 sg:pub.10.1038/nbt0502-505
    35 sg:pub.10.1038/ncb1101-945
    36 sg:pub.10.1038/ncb728
    37 sg:pub.10.1038/ncb777
    38 sg:pub.10.1038/ng944
    39 sg:pub.10.1038/nm725
    40 sg:pub.10.1186/1471-2180-1-34
    41 https://app.dimensions.ai/details/publication/pub.1074890809
    42 https://app.dimensions.ai/details/publication/pub.1074980687
    43 https://app.dimensions.ai/details/publication/pub.1078927779
    44 https://app.dimensions.ai/details/publication/pub.1080016070
    45 https://app.dimensions.ai/details/publication/pub.1083196589
    46 https://app.dimensions.ai/details/publication/pub.1083315631
    47 https://app.dimensions.ai/details/publication/pub.1083357043
    48 https://doi.org/10.1006/bbrc.2001.5707
    49 https://doi.org/10.1006/dbio.1999.9523
    50 https://doi.org/10.1006/mthe.2001.0481
    51 https://doi.org/10.1016/0092-8674(93)90529-y
    52 https://doi.org/10.1016/0092-8674(93)90530-4
    53 https://doi.org/10.1016/s0092-8674(00)80368-2
    54 https://doi.org/10.1016/s0092-8674(00)80620-0
    55 https://doi.org/10.1016/s0092-8674(00)80864-8
    56 https://doi.org/10.1016/s0092-8674(00)81644-x
    57 https://doi.org/10.1016/s0092-8674(00)81906-6
    58 https://doi.org/10.1016/s0092-8674(01)00431-7
    59 https://doi.org/10.1016/s0092-8674(01)00506-2
    60 https://doi.org/10.1016/s0092-8674(01)00547-5
    61 https://doi.org/10.1016/s0092-8674(01)00576-1
    62 https://doi.org/10.1016/s0092-8674(02)00863-2
    63 https://doi.org/10.1016/s0092-8674(02)00908-x
    64 https://doi.org/10.1016/s0092-8674(02)71133-1
    65 https://doi.org/10.1016/s0378-1119(00)00224-9
    66 https://doi.org/10.1016/s0960-9822(00)00323-7
    67 https://doi.org/10.1016/s0960-9822(00)00528-5
    68 https://doi.org/10.1016/s0960-9822(00)00732-6
    69 https://doi.org/10.1016/s0960-9822(01)00316-5
    70 https://doi.org/10.1016/s0960-9822(02)00665-6
    71 https://doi.org/10.1016/s0960-9822(02)00809-6
    72 https://doi.org/10.1016/s0960-9822(02)00975-2
    73 https://doi.org/10.1016/s1046-2023(02)00023-3
    74 https://doi.org/10.1016/s1097-2765(00)00106-4
    75 https://doi.org/10.1016/s1097-2765(02)00437-9
    76 https://doi.org/10.1016/s1097-2765(02)00541-5
    77 https://doi.org/10.1016/s1534-5807(01)00114-9
    78 https://doi.org/10.1017/s1355838202024032
    79 https://doi.org/10.1042/0264-6021:3630001
    80 https://doi.org/10.1042/bj3630001
    81 https://doi.org/10.1046/j.1365-313x.1999.00431.x
    82 https://doi.org/10.1073/pnas.032652399
    83 https://doi.org/10.1073/pnas.060034297
    84 https://doi.org/10.1073/pnas.072190799
    85 https://doi.org/10.1073/pnas.082117599
    86 https://doi.org/10.1073/pnas.092143499
    87 https://doi.org/10.1073/pnas.152327299
    88 https://doi.org/10.1073/pnas.171251798
    89 https://doi.org/10.1073/pnas.94.25.13437
    90 https://doi.org/10.1073/pnas.97.7.3142
    91 https://doi.org/10.1074/jbc.m106161200
    92 https://doi.org/10.1074/jbc.m107339200
    93 https://doi.org/10.1074/jbc.m201503200
    94 https://doi.org/10.1083/jcb.152.1.75
    95 https://doi.org/10.1083/jcb.200108088
    96 https://doi.org/10.1093/emboj/20.19.5443
    97 https://doi.org/10.1093/emboj/20.23.6877
    98 https://doi.org/10.1093/emboj/20.24.7240
    99 https://doi.org/10.1093/emboj/21.7.1723
    100 https://doi.org/10.1093/nar/26.22.5079
    101 https://doi.org/10.1093/nar/30.10.e46
    102 https://doi.org/10.1093/nar/30.8.1757
    103 https://doi.org/10.1101/gad.1004402
    104 https://doi.org/10.1101/gad.862301
    105 https://doi.org/10.1101/gad.880001
    106 https://doi.org/10.1101/gad.927801
    107 https://doi.org/10.1101/gad.950302
    108 https://doi.org/10.1101/gad.974702
    109 https://doi.org/10.1101/gad.981002
    110 https://doi.org/10.1105/tpc.003210
    111 https://doi.org/10.1105/tpc.010358
    112 https://doi.org/10.1126/science.1062039
    113 https://doi.org/10.1126/science.1062961
    114 https://doi.org/10.1126/science.1064023
    115 https://doi.org/10.1126/science.1064921
    116 https://doi.org/10.1126/science.1065062
    117 https://doi.org/10.1126/science.1065329
    118 https://doi.org/10.1126/science.1068999
    119 https://doi.org/10.1126/science.1070948
    120 https://doi.org/10.1126/science.1073827
    121 https://doi.org/10.1126/science.286.5441.950
    122 https://doi.org/10.1126/science.287.5462.2494
    123 https://doi.org/10.1128/jvi.76.18.9225-9231.2002
    124 schema:datePublished 2002-10
    125 schema:datePublishedReg 2002-10-01
    126 schema:description Among the 3 billion base pairs of the human genome, there are approximately 30,000-40,000 protein-coding genes, but the function of at least half of them remains unknown. A new tool - short interfering RNAs (siRNAs) - has now been developed for systematically deciphering the functions and interactions of these thousands of genes. siRNAs are an intermediate of RNA interference, the process by which double-stranded RNA silences homologous genes. Although the use of siRNAs to silence genes in vertebrate cells was only reported a year ago, the emerging literature indicates that most vertebrate genes can be studied with this technology.
    127 schema:genre research_article
    128 schema:inLanguage en
    129 schema:isAccessibleForFree false
    130 schema:isPartOf Nc7dea79896f041a2b5795a0636ebada6
    131 Nd574e3b7d99749ffb860f1252d926979
    132 sg:journal.1023607
    133 schema:name Gene silencing in mammals by small interfering RNAs
    134 schema:pagination 737-747
    135 schema:productId N0468b180b0234a69986dbfed00be3e6d
    136 N7859581b877a428b95514d089d71f27e
    137 N9f7e265fb65d41ddb32ccfc0c8d8c858
    138 Nc4aa4e9d2e7845b0ae96ef8e2316c109
    139 Nd6a5d27a5921423aaa2d9431532be29d
    140 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003050911
    141 https://doi.org/10.1038/nrg908
    142 schema:sdDatePublished 2019-04-11T11:55
    143 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    144 schema:sdPublisher N0f3a0d419419441885436c8215c71ec0
    145 schema:url http://www.nature.com/articles/nrg908
    146 sgo:license sg:explorer/license/
    147 sgo:sdDataset articles
    148 rdf:type schema:ScholarlyArticle
    149 N0468b180b0234a69986dbfed00be3e6d schema:name nlm_unique_id
    150 schema:value 100962779
    151 rdf:type schema:PropertyValue
    152 N05244e2b550540c6a11fb590a247e3f0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    153 schema:name MicroRNAs
    154 rdf:type schema:DefinedTerm
    155 N0f3a0d419419441885436c8215c71ec0 schema:name Springer Nature - SN SciGraph project
    156 rdf:type schema:Organization
    157 N193f053d780b45d5a58e909846d897cd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    158 schema:name Molecular Sequence Data
    159 rdf:type schema:DefinedTerm
    160 N230daa9f3320474c89c358cd295e9b06 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    161 schema:name Plants
    162 rdf:type schema:DefinedTerm
    163 N2334e1fe104c4160b88ab9374892d9de schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    164 schema:name Humans
    165 rdf:type schema:DefinedTerm
    166 N54a233151d9b4b76b53480c0648d8bf1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    167 schema:name Gene Targeting
    168 rdf:type schema:DefinedTerm
    169 N6470220cf024484f8c1b0e5d63915e5e rdf:first sg:person.013543306317.34
    170 rdf:rest Nf6aca8469ca546729cb3c4aab3ab4da3
    171 N7859581b877a428b95514d089d71f27e schema:name dimensions_id
    172 schema:value pub.1003050911
    173 rdf:type schema:PropertyValue
    174 N9f7e265fb65d41ddb32ccfc0c8d8c858 schema:name readcube_id
    175 schema:value 0e885a19108c43427c5fa00be637656c0d184f4ab3daaaa7aec58b56a970fd61
    176 rdf:type schema:PropertyValue
    177 Na4c2384ad2084beeb8c797853a215d74 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    178 schema:name Nucleic Acid Conformation
    179 rdf:type schema:DefinedTerm
    180 Nb20df21dd16046e4a232c6071506f72d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    181 schema:name RNA, Messenger
    182 rdf:type schema:DefinedTerm
    183 Nbfc232c165f348fabf3d83483e5ca520 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    184 schema:name Virus Diseases
    185 rdf:type schema:DefinedTerm
    186 Nc38d6fa9d377400bb24ac8515eebe60e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    187 schema:name Gene Silencing
    188 rdf:type schema:DefinedTerm
    189 Nc4aa4e9d2e7845b0ae96ef8e2316c109 schema:name doi
    190 schema:value 10.1038/nrg908
    191 rdf:type schema:PropertyValue
    192 Nc7dea79896f041a2b5795a0636ebada6 schema:volumeNumber 3
    193 rdf:type schema:PublicationVolume
    194 Nd574e3b7d99749ffb860f1252d926979 schema:issueNumber 10
    195 rdf:type schema:PublicationIssue
    196 Nd6a5d27a5921423aaa2d9431532be29d schema:name pubmed_id
    197 schema:value 12360232
    198 rdf:type schema:PropertyValue
    199 Ndebabce22f8a4040ad9b749ec8bd83cb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    200 schema:name Animals
    201 rdf:type schema:DefinedTerm
    202 Nee9f065114014816b2d58c06428a0d46 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    203 schema:name RNA, Small Interfering
    204 rdf:type schema:DefinedTerm
    205 Nf6aca8469ca546729cb3c4aab3ab4da3 rdf:first sg:person.01147001662.05
    206 rdf:rest rdf:nil
    207 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
    208 schema:name Biological Sciences
    209 rdf:type schema:DefinedTerm
    210 anzsrc-for:0604 schema:inDefinedTermSet anzsrc-for:
    211 schema:name Genetics
    212 rdf:type schema:DefinedTerm
    213 sg:journal.1023607 schema:issn 1471-0056
    214 1471-0064
    215 schema:name Nature Reviews Genetics
    216 rdf:type schema:Periodical
    217 sg:person.01147001662.05 schema:affiliation https://www.grid.ac/institutes/grid.116068.8
    218 schema:familyName Sharp
    219 schema:givenName Phillip A.
    220 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01147001662.05
    221 rdf:type schema:Person
    222 sg:person.013543306317.34 schema:affiliation https://www.grid.ac/institutes/grid.116068.8
    223 schema:familyName McManus
    224 schema:givenName Michael T.
    225 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013543306317.34
    226 rdf:type schema:Person
    227 sg:pub.10.1023/a:1009664109241 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037308227
    228 https://doi.org/10.1023/a:1009664109241
    229 rdf:type schema:CreativeWork
    230 sg:pub.10.1038/20215 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038481561
    231 https://doi.org/10.1038/20215
    232 rdf:type schema:CreativeWork
    233 sg:pub.10.1038/35002607 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047689840
    234 https://doi.org/10.1038/35002607
    235 rdf:type schema:CreativeWork
    236 sg:pub.10.1038/35005107 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053082190
    237 https://doi.org/10.1038/35005107
    238 rdf:type schema:CreativeWork
    239 sg:pub.10.1038/35030305 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020409977
    240 https://doi.org/10.1038/35030305
    241 rdf:type schema:CreativeWork
    242 sg:pub.10.1038/35040556 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041493395
    243 https://doi.org/10.1038/35040556
    244 rdf:type schema:CreativeWork
    245 sg:pub.10.1038/35053110 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042658253
    246 https://doi.org/10.1038/35053110
    247 rdf:type schema:CreativeWork
    248 sg:pub.10.1038/35078107 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028423924
    249 https://doi.org/10.1038/35078107
    250 rdf:type schema:CreativeWork
    251 sg:pub.10.1038/35079635 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044881407
    252 https://doi.org/10.1038/35079635
    253 rdf:type schema:CreativeWork
    254 sg:pub.10.1038/35081168 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052312028
    255 https://doi.org/10.1038/35081168
    256 rdf:type schema:CreativeWork
    257 sg:pub.10.1038/35088566 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001843561
    258 https://doi.org/10.1038/35088566
    259 rdf:type schema:CreativeWork
    260 sg:pub.10.1038/35888 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018713804
    261 https://doi.org/10.1038/35888
    262 rdf:type schema:CreativeWork
    263 sg:pub.10.1038/418038a schema:sameAs https://app.dimensions.ai/details/publication/pub.1006471802
    264 https://doi.org/10.1038/418038a
    265 rdf:type schema:CreativeWork
    266 sg:pub.10.1038/72850 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015018717
    267 https://doi.org/10.1038/72850
    268 rdf:type schema:CreativeWork
    269 sg:pub.10.1038/78531 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000314042
    270 https://doi.org/10.1038/78531
    271 rdf:type schema:CreativeWork
    272 sg:pub.10.1038/nature00873 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016155470
    273 https://doi.org/10.1038/nature00873
    274 rdf:type schema:CreativeWork
    275 sg:pub.10.1038/nature00896 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050512564
    276 https://doi.org/10.1038/nature00896
    277 rdf:type schema:CreativeWork
    278 sg:pub.10.1038/nbt0502-497 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000546028
    279 https://doi.org/10.1038/nbt0502-497
    280 rdf:type schema:CreativeWork
    281 sg:pub.10.1038/nbt0502-500 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017195653
    282 https://doi.org/10.1038/nbt0502-500
    283 rdf:type schema:CreativeWork
    284 sg:pub.10.1038/nbt0502-505 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032921883
    285 https://doi.org/10.1038/nbt0502-505
    286 rdf:type schema:CreativeWork
    287 sg:pub.10.1038/ncb1101-945 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001090536
    288 https://doi.org/10.1038/ncb1101-945
    289 rdf:type schema:CreativeWork
    290 sg:pub.10.1038/ncb728 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044541930
    291 https://doi.org/10.1038/ncb728
    292 rdf:type schema:CreativeWork
    293 sg:pub.10.1038/ncb777 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000490799
    294 https://doi.org/10.1038/ncb777
    295 rdf:type schema:CreativeWork
    296 sg:pub.10.1038/ng944 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042354461
    297 https://doi.org/10.1038/ng944
    298 rdf:type schema:CreativeWork
    299 sg:pub.10.1038/nm725 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010188992
    300 https://doi.org/10.1038/nm725
    301 rdf:type schema:CreativeWork
    302 sg:pub.10.1186/1471-2180-1-34 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001533836
    303 https://doi.org/10.1186/1471-2180-1-34
    304 rdf:type schema:CreativeWork
    305 https://app.dimensions.ai/details/publication/pub.1074890809 schema:CreativeWork
    306 https://app.dimensions.ai/details/publication/pub.1074980687 schema:CreativeWork
    307 https://app.dimensions.ai/details/publication/pub.1078927779 schema:CreativeWork
    308 https://app.dimensions.ai/details/publication/pub.1080016070 schema:CreativeWork
    309 https://app.dimensions.ai/details/publication/pub.1083196589 schema:CreativeWork
    310 https://app.dimensions.ai/details/publication/pub.1083315631 schema:CreativeWork
    311 https://app.dimensions.ai/details/publication/pub.1083357043 schema:CreativeWork
    312 https://doi.org/10.1006/bbrc.2001.5707 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048647938
    313 rdf:type schema:CreativeWork
    314 https://doi.org/10.1006/dbio.1999.9523 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045998074
    315 rdf:type schema:CreativeWork
    316 https://doi.org/10.1006/mthe.2001.0481 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017946445
    317 rdf:type schema:CreativeWork
    318 https://doi.org/10.1016/0092-8674(93)90529-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1051619915
    319 rdf:type schema:CreativeWork
    320 https://doi.org/10.1016/0092-8674(93)90530-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039515219
    321 rdf:type schema:CreativeWork
    322 https://doi.org/10.1016/s0092-8674(00)80368-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005088934
    323 rdf:type schema:CreativeWork
    324 https://doi.org/10.1016/s0092-8674(00)80620-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035978762
    325 rdf:type schema:CreativeWork
    326 https://doi.org/10.1016/s0092-8674(00)80864-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042263715
    327 rdf:type schema:CreativeWork
    328 https://doi.org/10.1016/s0092-8674(00)81644-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1014004558
    329 rdf:type schema:CreativeWork
    330 https://doi.org/10.1016/s0092-8674(00)81906-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024442258
    331 rdf:type schema:CreativeWork
    332 https://doi.org/10.1016/s0092-8674(01)00431-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036555460
    333 rdf:type schema:CreativeWork
    334 https://doi.org/10.1016/s0092-8674(01)00506-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046862106
    335 rdf:type schema:CreativeWork
    336 https://doi.org/10.1016/s0092-8674(01)00547-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021383396
    337 rdf:type schema:CreativeWork
    338 https://doi.org/10.1016/s0092-8674(01)00576-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019924014
    339 rdf:type schema:CreativeWork
    340 https://doi.org/10.1016/s0092-8674(02)00863-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013070988
    341 rdf:type schema:CreativeWork
    342 https://doi.org/10.1016/s0092-8674(02)00908-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1032329761
    343 rdf:type schema:CreativeWork
    344 https://doi.org/10.1016/s0092-8674(02)71133-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003818083
    345 rdf:type schema:CreativeWork
    346 https://doi.org/10.1016/s0378-1119(00)00224-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002450910
    347 rdf:type schema:CreativeWork
    348 https://doi.org/10.1016/s0960-9822(00)00323-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005820102
    349 rdf:type schema:CreativeWork
    350 https://doi.org/10.1016/s0960-9822(00)00528-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016508102
    351 rdf:type schema:CreativeWork
    352 https://doi.org/10.1016/s0960-9822(00)00732-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023413773
    353 rdf:type schema:CreativeWork
    354 https://doi.org/10.1016/s0960-9822(01)00316-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031334372
    355 rdf:type schema:CreativeWork
    356 https://doi.org/10.1016/s0960-9822(02)00665-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052166677
    357 rdf:type schema:CreativeWork
    358 https://doi.org/10.1016/s0960-9822(02)00809-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012534253
    359 rdf:type schema:CreativeWork
    360 https://doi.org/10.1016/s0960-9822(02)00975-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012430811
    361 rdf:type schema:CreativeWork
    362 https://doi.org/10.1016/s1046-2023(02)00023-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004916138
    363 rdf:type schema:CreativeWork
    364 https://doi.org/10.1016/s1097-2765(00)00106-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050620574
    365 rdf:type schema:CreativeWork
    366 https://doi.org/10.1016/s1097-2765(02)00437-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027751467
    367 rdf:type schema:CreativeWork
    368 https://doi.org/10.1016/s1097-2765(02)00541-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019720069
    369 rdf:type schema:CreativeWork
    370 https://doi.org/10.1016/s1534-5807(01)00114-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033080869
    371 rdf:type schema:CreativeWork
    372 https://doi.org/10.1017/s1355838202024032 schema:sameAs https://app.dimensions.ai/details/publication/pub.1054923777
    373 rdf:type schema:CreativeWork
    374 https://doi.org/10.1042/0264-6021:3630001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1056716070
    375 rdf:type schema:CreativeWork
    376 https://doi.org/10.1042/bj3630001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022027741
    377 rdf:type schema:CreativeWork
    378 https://doi.org/10.1046/j.1365-313x.1999.00431.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1006718234
    379 rdf:type schema:CreativeWork
    380 https://doi.org/10.1073/pnas.032652399 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021560343
    381 rdf:type schema:CreativeWork
    382 https://doi.org/10.1073/pnas.060034297 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035793328
    383 rdf:type schema:CreativeWork
    384 https://doi.org/10.1073/pnas.072190799 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004988443
    385 rdf:type schema:CreativeWork
    386 https://doi.org/10.1073/pnas.082117599 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008914829
    387 rdf:type schema:CreativeWork
    388 https://doi.org/10.1073/pnas.092143499 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011544791
    389 rdf:type schema:CreativeWork
    390 https://doi.org/10.1073/pnas.152327299 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013985622
    391 rdf:type schema:CreativeWork
    392 https://doi.org/10.1073/pnas.171251798 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017733703
    393 rdf:type schema:CreativeWork
    394 https://doi.org/10.1073/pnas.94.25.13437 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034844741
    395 rdf:type schema:CreativeWork
    396 https://doi.org/10.1073/pnas.97.7.3142 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017815429
    397 rdf:type schema:CreativeWork
    398 https://doi.org/10.1074/jbc.m106161200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031330462
    399 rdf:type schema:CreativeWork
    400 https://doi.org/10.1074/jbc.m107339200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074879749
    401 rdf:type schema:CreativeWork
    402 https://doi.org/10.1074/jbc.m201503200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016374367
    403 rdf:type schema:CreativeWork
    404 https://doi.org/10.1083/jcb.152.1.75 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001139584
    405 rdf:type schema:CreativeWork
    406 https://doi.org/10.1083/jcb.200108088 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008287619
    407 rdf:type schema:CreativeWork
    408 https://doi.org/10.1093/emboj/20.19.5443 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032445653
    409 rdf:type schema:CreativeWork
    410 https://doi.org/10.1093/emboj/20.23.6877 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004775429
    411 rdf:type schema:CreativeWork
    412 https://doi.org/10.1093/emboj/20.24.7240 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029866593
    413 rdf:type schema:CreativeWork
    414 https://doi.org/10.1093/emboj/21.7.1723 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000915566
    415 rdf:type schema:CreativeWork
    416 https://doi.org/10.1093/nar/26.22.5079 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052017314
    417 rdf:type schema:CreativeWork
    418 https://doi.org/10.1093/nar/30.10.e46 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041374327
    419 rdf:type schema:CreativeWork
    420 https://doi.org/10.1093/nar/30.8.1757 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001204140
    421 rdf:type schema:CreativeWork
    422 https://doi.org/10.1101/gad.1004402 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052409649
    423 rdf:type schema:CreativeWork
    424 https://doi.org/10.1101/gad.862301 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000961502
    425 rdf:type schema:CreativeWork
    426 https://doi.org/10.1101/gad.880001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036718422
    427 rdf:type schema:CreativeWork
    428 https://doi.org/10.1101/gad.927801 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006489317
    429 rdf:type schema:CreativeWork
    430 https://doi.org/10.1101/gad.950302 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031429267
    431 rdf:type schema:CreativeWork
    432 https://doi.org/10.1101/gad.974702 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025305717
    433 rdf:type schema:CreativeWork
    434 https://doi.org/10.1101/gad.981002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017530405
    435 rdf:type schema:CreativeWork
    436 https://doi.org/10.1105/tpc.003210 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051968372
    437 rdf:type schema:CreativeWork
    438 https://doi.org/10.1105/tpc.010358 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042690077
    439 rdf:type schema:CreativeWork
    440 https://doi.org/10.1126/science.1062039 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062445158
    441 rdf:type schema:CreativeWork
    442 https://doi.org/10.1126/science.1062961 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049854130
    443 rdf:type schema:CreativeWork
    444 https://doi.org/10.1126/science.1064023 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062445376
    445 rdf:type schema:CreativeWork
    446 https://doi.org/10.1126/science.1064921 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023512870
    447 rdf:type schema:CreativeWork
    448 https://doi.org/10.1126/science.1065062 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023084018
    449 rdf:type schema:CreativeWork
    450 https://doi.org/10.1126/science.1065329 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049696178
    451 rdf:type schema:CreativeWork
    452 https://doi.org/10.1126/science.1068999 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020993705
    453 rdf:type schema:CreativeWork
    454 https://doi.org/10.1126/science.1070948 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015520291
    455 rdf:type schema:CreativeWork
    456 https://doi.org/10.1126/science.1073827 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062446723
    457 rdf:type schema:CreativeWork
    458 https://doi.org/10.1126/science.286.5441.950 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018807570
    459 rdf:type schema:CreativeWork
    460 https://doi.org/10.1126/science.287.5462.2494 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053264156
    461 rdf:type schema:CreativeWork
    462 https://doi.org/10.1128/jvi.76.18.9225-9231.2002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007665434
    463 rdf:type schema:CreativeWork
    464 https://www.grid.ac/institutes/grid.116068.8 schema:alternateName Massachusetts Institute of Technology
    465 schema:name Center for Cancer Research, Massachusetts Institute of Technology, 40 Ames Street E17-526, Cambridge, Massachusetts 02139, USA.
    466 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...