Patterns of linkage disequilibrium in the human genome View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2002-04

AUTHORS

Kristin G. Ardlie, Leonid Kruglyak, Mark Seielstad

ABSTRACT

Particular alleles at neighbouring loci tend to be co-inherited. For tightly linked loci, this might lead to associations between alleles in the population a property known as linkage disequilibrium (LD). LD has recently become the focus of intense study in the hope that it might facilitate the mapping of complex disease loci through whole-genome association studies. This approach depends crucially on the patterns of LD in the human genome. In this review, we draw on empirical studies in humans and Drosophila, as well as simulation studies, to assess the current state of knowledge about patterns of LD, and consider the implications for the use of LD as a mapping tool. More... »

PAGES

299-309

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  • Journal

    TITLE

    Nature Reviews Genetics

    ISSUE

    4

    VOLUME

    3

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nrg777

    DOI

    http://dx.doi.org/10.1038/nrg777

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1000451502

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/11967554


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