Gene expression regulation mediated through reversible m6A RNA methylation View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2014-05

AUTHORS

Ye Fu, Dan Dominissini, Gideon Rechavi, Chuan He

ABSTRACT

Cellular RNAs carry diverse chemical modifications that used to be regarded as static and having minor roles in 'fine-tuning' structural and functional properties of RNAs. In this Review, we focus on reversible methylation through the most prevalent mammalian mRNA internal modification, N(6)-methyladenosine (m(6)A). Recent studies have discovered protein 'writers', 'erasers' and 'readers' of this RNA chemical mark, as well as its dynamic deposition on mRNA and other types of nuclear RNA. These findings strongly indicate dynamic regulatory roles that are analogous to the well-known reversible epigenetic modifications of DNA and histone proteins. This reversible RNA methylation adds a new dimension to the developing picture of post-transcriptional regulation of gene expression. More... »

PAGES

293-306

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nrg3724

DOI

http://dx.doi.org/10.1038/nrg3724

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1004136167

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/24662220


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