RNA-directed DNA methylation: an epigenetic pathway of increasing complexity View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2014-06

AUTHORS

Marjori A. Matzke, Rebecca A. Mosher

ABSTRACT

RNA-directed DNA methylation (RdDM) is the major small RNA-mediated epigenetic pathway in plants. RdDM requires a specialized transcriptional machinery that comprises two plant-specific RNA polymerases - Pol IV and Pol V - and a growing number of accessory proteins, the functions of which in the RdDM mechanism are only partially understood. Recent work has revealed variations in the canonical RdDM pathway and identified factors that recruit Pol IV and Pol V to specific target sequences. RdDM, which transcriptionally represses a subset of transposons and genes, is implicated in pathogen defence, stress responses and reproduction, as well as in interallelic and intercellular communication. More... »

PAGES

394-408

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    http://scigraph.springernature.com/pub.10.1038/nrg3683

    DOI

    http://dx.doi.org/10.1038/nrg3683

    DIMENSIONS

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    PUBMED

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