Sequencing depth and coverage: key considerations in genomic analyses View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2014-02

AUTHORS

David Sims, Ian Sudbery, Nicholas E. Ilott, Andreas Heger, Chris P. Ponting

ABSTRACT

Sequencing technologies have placed a wide range of genomic analyses within the capabilities of many laboratories. However, sequencing costs often set limits to the amount of sequences that can be generated and, consequently, the biological outcomes that can be achieved from an experimental design. In this Review, we discuss the issue of sequencing depth in the design of next-generation sequencing experiments. We review current guidelines and precedents on the issue of coverage, as well as their underlying considerations, for four major study designs, which include de novo genome sequencing, genome resequencing, transcriptome sequencing and genomic location analyses (for example, chromatin immunoprecipitation followed by sequencing (ChIP-seq) and chromosome conformation capture (3C)). More... »

PAGES

121-132

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    URI

    http://scigraph.springernature.com/pub.10.1038/nrg3642

    DOI

    http://dx.doi.org/10.1038/nrg3642

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1010746394

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/24434847


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