Meiotic recombination in mammals: localization and regulation View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2013-11

AUTHORS

Frédéric Baudat, Yukiko Imai, Bernard de Massy

ABSTRACT

During meiosis, a programmed induction of DNA double-strand breaks (DSBs) leads to the exchange of genetic material between homologous chromosomes. These exchanges increase genome diversity and are essential for proper chromosome segregation at the first meiotic division. Recent findings have highlighted an unexpected molecular control of the distribution of meiotic DSBs in mammals by a rapidly evolving gene, PR domain-containing 9 (PRDM9), and genome-wide analyses have facilitated the characterization of meiotic DSB sites at unprecedented resolution. In addition, the identification of new players in DSB repair processes has allowed the delineation of recombination pathways that have two major outcomes, crossovers and non-crossovers, which have distinct mechanistic roles and consequences for genome evolution. More... »

PAGES

794-806

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nrg3573

DOI

http://dx.doi.org/10.1038/nrg3573

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1009006225

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/24136506


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