DNA methylation profiling in the clinic: applications and challenges View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2012-10

AUTHORS

Holger Heyn, Manel Esteller

ABSTRACT

Knowledge of epigenetic alterations in disease is rapidly increasing owing to the development of genome-wide techniques for their identification. The ever-growing number of genes that show epigenetic alterations in disease emphasizes the crucial role of these epigenetic alterations - particularly DNA methylation - for future diagnosis, prognosis and prediction of response to therapies. This Review focuses on epigenetic profiling, which has started to be of clinical value in cancer and may in the future be extended to other diseases, such as neurological and autoimmune disorders. More... »

PAGES

679

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  • Journal

    TITLE

    Nature Reviews Genetics

    ISSUE

    10

    VOLUME

    13

    Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nrg3270

    DOI

    http://dx.doi.org/10.1038/nrg3270

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1003814753

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/22945394


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    RDF/XML is a standard XML format for linked data.

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