Reconciling the analysis of IBD and IBS in complex trait studies View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2010-11

AUTHORS

Joseph E. Powell, Peter M. Visscher, Michael E. Goddard

ABSTRACT

Identity by descent (IBD) is a fundamental concept in genetics and refers to alleles that are descended from a common ancestor in a base population. Identity by state (IBS) simply refers to alleles that are the same, irrespective of whether they are inherited from a recent ancestor. In modern applications, IBD relationships are estimated from genetic markers in individuals without any known relationship. This can lead to erroneous inference because a consistent base population is not used. We argue that the purpose of most IBD calculations is to predict IBS at unobserved loci. Recognizing this aim leads to better methods to estimating IBD with benefits in mapping genes, estimating genetic variance and predicting inbreeding depression. More... »

PAGES

800

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nrg2865

DOI

http://dx.doi.org/10.1038/nrg2865

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1021265732

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/20877324


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