Genome editing with engineered zinc finger nucleases View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2010-09

AUTHORS

Fyodor D. Urnov, Edward J. Rebar, Michael C. Holmes, H. Steve Zhang, Philip D. Gregory

ABSTRACT

Reverse genetics in model organisms such as Drosophila melanogaster, Arabidopsis thaliana, zebrafish and rats, efficient genome engineering in human embryonic stem and induced pluripotent stem cells, targeted integration in crop plants, and HIV resistance in immune cells - this broad range of outcomes has resulted from the application of the same core technology: targeted genome cleavage by engineered, sequence-specific zinc finger nucleases followed by gene modification during subsequent repair. Such 'genome editing' is now established in human cells and a number of model organisms, thus opening the door to a range of new experimental and therapeutic possibilities. More... »

PAGES

636

References to SciGraph publications

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  • Journal

    TITLE

    Nature Reviews Genetics

    ISSUE

    9

    VOLUME

    11

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nrg2842

    DOI

    http://dx.doi.org/10.1038/nrg2842

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1018939216

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/20717154


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