The evolution of gene duplications: classifying and distinguishing between models View Full Text


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Article Info

DATE

2010-01-06

AUTHORS

Hideki Innan, Fyodor Kondrashov

ABSTRACT

Key PointsModels of gene duplication can be classified into four major categories according to the mode of selection in the early phases of the evolution of the duplicated copies.The evolutionary and population genetic assumptions for each model are described in this Review.Many models show that under certain conditions, a newly arisen duplicated copy of a coding gene can be stably maintained by selection after it is fixed in the population.Summaries of several models for the evolution and maintenance of gene duplications are provided. They have different evolutionary predictions in the phases before the final fate of the duplicated copy is determined.The necessary data and the experimental designs to obtain such data that are needed to distinguish between the different models are described. The synonymous–non-synonymous ratio of divergence between duplicated copies is not informative for distinguishing between different models.A pertinent issue in the evolution of gene duplications is the role of selection in their fixation. To resolve this issue, it is necessary to obtain polymorphisms in and around copy-number variants.Gene conversion between duplicates plays an important part in the early stages of the evolution of duplicated genes, depending on the model in question, and can promote or inhibit the maintenance of the gene copy. More... »

PAGES

97-108

References to SciGraph publications

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