ChIP–seq: advantages and challenges of a maturing technology View Full Text


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Article Info

DATE

2009-10

AUTHORS

Peter J Park

ABSTRACT

Chromatin immunoprecipitation followed by sequencing (ChIP-seq) is a technique for genome-wide profiling of DNA-binding proteins, histone modifications or nucleosomes. Owing to the tremendous progress in next-generation sequencing technology, ChIP-seq offers higher resolution, less noise and greater coverage than its array-based predecessor ChIP-chip. With the decreasing cost of sequencing, ChIP-seq has become an indispensable tool for studying gene regulation and epigenetic mechanisms. In this Review, I describe the benefits and challenges in harnessing this technique with an emphasis on issues related to experimental design and data analysis. ChIP-seq experiments generate large quantities of data, and effective computational analysis will be crucial for uncovering biological mechanisms. More... »

PAGES

669-680

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  • Journal

    TITLE

    Nature Reviews Genetics

    ISSUE

    10

    VOLUME

    10

    Author Affiliations

    Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nrg2641

    DOI

    http://dx.doi.org/10.1038/nrg2641

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1006115199

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/19736561


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