Causes and consequences of microRNA dysregulation in cancer View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2009-10

AUTHORS

Carlo M Croce

ABSTRACT

Over the past several years it has become clear that alterations in the expression of microRNA (miRNA) genes contribute to the pathogenesis of most--if not all--human malignancies. These alterations can be caused by various mechanisms, including deletions, amplifications or mutations involving miRNA loci, epigenetic silencing or the dysregulation of transcription factors that target specific miRNAs. Because malignant cells show dependence on the dysregulated expression of miRNA genes, which in turn control or are controlled by the dysregulation of multiple protein-coding oncogenes or tumour suppressor genes, these small RNAs provide important opportunities for the development of future miRNA-based therapies. More... »

PAGES

704-714

Journal

TITLE

Nature Reviews Genetics

ISSUE

10

VOLUME

10

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nrg2634

    DOI

    http://dx.doi.org/10.1038/nrg2634

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1040605557

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/19763153


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