Spatial patterns of variation due to natural selection in humans View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2009-11

AUTHORS

John Novembre, Anna Di Rienzo

ABSTRACT

Empowered by technology and sampling efforts designed to facilitate genome-wide association mapping, human geneticists are now studying the geography of genetic variation in unprecedented detail. With high genomic coverage and geographic resolution, these studies are identifying loci with spatial signatures of selection, such as extreme levels of differentiation and correlations with environmental variables. Collectively, patterns at these loci are beginning to provide new insights into the process of human adaptation. Here, we review the challenges of these studies and emerging results, including how human population structure has influenced the response to novel selective pressures. More... »

PAGES

745-755

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nrg2632

    DOI

    http://dx.doi.org/10.1038/nrg2632

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1052003026

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/19823195


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