From DNA sequence to transcriptional behaviour: a quantitative approach View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2009-07

AUTHORS

Eran Segal, Jonathan Widom

ABSTRACT

Complex transcriptional behaviours are encoded in the DNA sequences of gene regulatory regions. Advances in our understanding of these behaviours have been recently gained through quantitative models that describe how molecules such as transcription factors and nucleosomes interact with genomic sequences. An emerging view is that every regulatory sequence is associated with a unique binding affinity landscape for each molecule and, consequently, with a unique set of molecule-binding configurations and transcriptional outputs. We present a quantitative framework based on existing methods that unifies these ideas. This framework explains many experimental observations regarding the binding patterns of factors and nucleosomes and the dynamics of transcriptional activation. It can also be used to model more complex phenomena such as transcriptional noise and the evolution of transcriptional regulation. More... »

PAGES

443-456

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nrg2591

    DOI

    http://dx.doi.org/10.1038/nrg2591

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1041068568

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/19506578


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