A census of human transcription factors: function, expression and evolution View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2009-04

AUTHORS

Juan M Vaquerizas, Sarah K Kummerfeld, Sarah A Teichmann, Nicholas M Luscombe

ABSTRACT

Transcription factors are key cellular components that control gene expression: their activities determine how cells function and respond to the environment. Currently, there is great interest in research into human transcriptional regulation. However, surprisingly little is known about these regulators themselves. For example, how many transcription factors does the human genome contain? How are they expressed in different tissues? Are they evolutionarily conserved? Here, we present an analysis of 1,391 manually curated sequence-specific DNA-binding transcription factors, their functions, genomic organization and evolutionary conservation. Much remains to be explored, but this study provides a solid foundation for future investigations to elucidate regulatory mechanisms underlying diverse mammalian biological processes. More... »

PAGES

252-263

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    URI

    http://scigraph.springernature.com/pub.10.1038/nrg2538

    DOI

    http://dx.doi.org/10.1038/nrg2538

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1047820135

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/19274049


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    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/nrg2538'

    RDF/XML is a standard XML format for linked data.

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