Genome–wide association studies provide new insights into type 2 diabetes aetiology View Full Text


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Article Info

DATE

2007-09

AUTHORS

Timothy M Frayling

ABSTRACT

Human geneticists are currently in the middle of a race. Thanks to a new technology in the form of 'genome-wide chips', investigators can potentially find many novel disease genes in one large experiment. Type 2 diabetes has been hot out of the blocks with six recent publications that together provide convincing evidence for six new gene regions involved in the condition. Together with candidate approaches, these studies have identified 11 confirmed genomic regions that alter the risk of type 2 diabetes in the European population. One of these regions, the fat mass and obesity associated gene (FTO), represents by far the best example of an association between common variation and fat mass in the general population. More... »

PAGES

657-662

References to SciGraph publications

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  • 2007-02. A genome-wide association study identifies novel risk loci for type 2 diabetes in NATURE
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  • 2007-08. Two variants on chromosome 17 confer prostate cancer risk, and the one in TCF2 protects against type 2 diabetes in NATURE GENETICS
  • 2005-10. Cdk5-dependent regulation of glucose-stimulated insulin secretion in NATURE MEDICINE
  • 1998-10. A gene encoding a transmembrane protein is mutated in patients with diabetes mellitus and optic atrophy (Wolfram syndrome) in NATURE GENETICS
  • 2007-06-07. Replicating genotype–phenotype associations in NATURE
  • 2000-10. Genetic variation in the gene encoding calpain-10 is associated with type 2 diabetes mellitus in NATURE GENETICS
  • 2006-03. Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes in NATURE GENETICS
  • 1988-07. Type 2 (non-insulin-dependent) diabetes mellitus new genetics for old nightmares in DIABETOLOGIA
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nrg2178

    DOI

    http://dx.doi.org/10.1038/nrg2178

    DIMENSIONS

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    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/17703236


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