Genome-wide transcription and the implications for genomic organization View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2007-06

AUTHORS

Philipp Kapranov, Aarron T Willingham, Thomas R Gingeras

ABSTRACT

Recent evidence of genome-wide transcription in several species indicates that the amount of transcription that occurs cannot be entirely accounted for by current sets of genome-wide annotations. Evidence indicates that most of both strands of the human genome might be transcribed, implying extensive overlap of transcriptional units and regulatory elements. These observations suggest that genomic architecture is not colinear, but is instead interleaved and modular, and that the same genomic sequences are multifunctional: that is, used for multiple independently regulated transcripts and as regulatory regions. What are the implications and consequences of such an interleaved genomic architecture in terms of increased information content, transcriptional complexity, evolution and disease states? More... »

PAGES

413-423

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nrg2083

    DOI

    http://dx.doi.org/10.1038/nrg2083

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1025632491

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/17486121


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    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/nrg2083'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/nrg2083'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/nrg2083'

    RDF/XML is a standard XML format for linked data.

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