Dosage compensation: the beginning and end of generalization View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2007-01

AUTHORS

Tobias Straub, Peter B. Becker

ABSTRACT

The genomes of higher eukaryotes are carefully balanced systems of gene expression that compensate for the different numbers of sex chromosomes in the two sexes by adjusting gene expression levels. Different strategies for sex chromosome dosage compensation have evolved, which all involve modulating chromatin structure as a means to fine-tune transcription levels. As data accumulate, previous over-simplifications are being revised, and novel features of the compensation processes are gaining attention, many of which are of sufficient global validity to influence our view on gene expression beyond the realm of dosage compensation itself. More... »

PAGES

47-57

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nrg2013

    DOI

    http://dx.doi.org/10.1038/nrg2013

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1048318512

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/17173057


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