The role of double-strand break repair — insights from human genetics View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2006-01

AUTHORS

Mark O'Driscoll, Penny A Jeggo

ABSTRACT

The efficient repair of DNA double-strand breaks is crucial in safeguarding the genomic integrity of organisms. Responses to double-strand breaks include complex signal-transduction, cell-cycle-checkpoint and repair pathways. Defects in these pathways lead to several human disorders with pleiotropic clinical features. Dissection of the molecular basis that underlies the diverse clinical features is enhancing our understanding of the damage-response mechanisms and their role in development, and might ultimately facilitate treatment. More... »

PAGES

45-54

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nrg1746

    DOI

    http://dx.doi.org/10.1038/nrg1746

    DIMENSIONS

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    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/16369571


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