The new cytogenetics: blurring the boundaries with molecular biology View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2005-10

AUTHORS

Michael R Speicher, Nigel P Carter

ABSTRACT

Exciting advances in fluorescence in situ hybridization and array-based techniques are changing the nature of cytogenetics, in both basic research and molecular diagnostics. Cytogenetic analysis now extends beyond the simple description of the chromosomal status of a genome and allows the study of fundamental biological questions, such as the nature of inherited syndromes, the genomic changes that are involved in tumorigenesis and the three-dimensional organization of the human genome. The high resolution that is achieved by these techniques, particularly by microarray technologies such as array comparative genomic hybridization, is blurring the traditional distinction between cytogenetics and molecular biology. More... »

PAGES

782-792

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nrg1692

DOI

http://dx.doi.org/10.1038/nrg1692

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1035689784

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/16145555


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