Mapping by admixture linkage disequilibrium: advances, limitations and guidelines View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2005-08

AUTHORS

Michael W Smith, Stephen J O'Brien

ABSTRACT

Mapping by admixture linkage disequilibrium (MALD) is a theoretically powerful, although unproven, approach to mapping genetic variants that are involved in human disease. MALD takes advantage of long-range haplotypes that are generated by gene flow among recently admixed ethnic groups, such as African-Americans and Latinos. Under ideal circumstances, MALD will have more power to detect some genetic variants than other types of genome-wide association study that are carried out among more ethnically homogeneous populations. It will also require 200-500 times fewer markers, providing a significant economic advantage. The MALD approach is now being applied, with results expected in the near future. More... »

PAGES

623-632

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nrg1657

    DOI

    http://dx.doi.org/10.1038/nrg1657

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1012092299

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/16012528


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