Prions as adaptive conduits of memory and inheritance View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2005-06

AUTHORS

James Shorter, Susan Lindquist

ABSTRACT

Changes in protein conformation drive most biological processes, but none have seized the imagination of scientists and the public alike as have the self-replicating conformations of prions. Prions transmit lethal neurodegenerative diseases by means of the food chain. However, self-replicating protein conformations can also constitute molecular memories that transmit genetic information. Here, we showcase definitive evidence for the prion hypothesis and discuss examples in which prion-encoded heritable information has been harnessed during evolution to confer selective advantages. We then describe situations in which prion-enciphered events might have essential roles in long-term memory formation, transcriptional memory and genome-wide expression patterns. More... »

PAGES

435-450

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nrg1616

    DOI

    http://dx.doi.org/10.1038/nrg1616

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1019171627

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/15931169


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