Gene map of the extended human MHC View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2004-12

AUTHORS

Roger Horton, Laurens Wilming, Vikki Rand, Ruth C Lovering, Elspeth A Bruford, Varsha K Khodiyar, Michael J Lush, Sue Povey, C Conover Talbot, Mathew W Wright, Hester M Wain, John Trowsdale, Andreas Ziegler, Stephan Beck

ABSTRACT

The major histocompatibility complex (MHC) is the most important region in the vertebrate genome with respect to infection and autoimmunity, and is crucial in adaptive and innate immunity. Decades of biomedical research have revealed many MHC genes that are duplicated, polymorphic and associated with more diseases than any other region of the human genome. The recent completion of several large-scale studies offers the opportunity to assimilate the latest data into an integrated gene map of the extended human MHC. Here, we present this map and review its content in relation to paralogy, polymorphism, immune function and disease. More... »

PAGES

889-899

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nrg1489

    DOI

    http://dx.doi.org/10.1038/nrg1489

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1039683825

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/15573121


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