Advanced sequencing technologies: methods and goals View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2004-05

AUTHORS

Jay Shendure, Robi D. Mitra, Chris Varma, George M. Church

ABSTRACT

Nearly three decades have passed since the invention of electrophoretic methods for DNA sequencing. The exponential growth in the cost-effectiveness of sequencing has been driven by automation and by numerous creative refinements of Sanger sequencing, rather than through the invention of entirely new methods. Various novel sequencing technologies are being developed, each aspiring to reduce costs to the point at which the genomes of individual humans could be sequenced as part of routine health care. Here, we review these technologies, and discuss the potential impact of such a 'personal genome project' on both the research community and on society. More... »

PAGES

335-344

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  • Journal

    TITLE

    Nature Reviews Genetics

    ISSUE

    5

    VOLUME

    5

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nrg1325

    DOI

    http://dx.doi.org/10.1038/nrg1325

    DIMENSIONS

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    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/15143316


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