Ontology type: schema:ScholarlyArticle
2004-04
AUTHORSWyeth W. Wasserman, Albin Sandelin
ABSTRACTKey PointsPromoter prediction software can succeed for the ∼50% of genes with CpG islands or for genes with abundant transcript data.Predictions of individual transcription-factor binding sites (TFBSs) are unreliable owing to the promiscuous binding of transcription factors.Comparative genome sequence analysis (phylogenetic footprinting) can eliminate up to 90% of false binding-site predictions; however, true sites are still obscured by the false predictions.Analysis of clusters of TFBSs in cis-regulatory modules can generate reliable predictions of regulatory regions.New methods are emerging to improve the detection of sequences that regulate gene transcription. More... »
PAGES276-287
http://scigraph.springernature.com/pub.10.1038/nrg1315
DOIhttp://dx.doi.org/10.1038/nrg1315
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PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/15131651
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