Systematic genome-wide screens of gene function View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2004-01

AUTHORS

Anne E Carpenter, David M Sabatini

ABSTRACT

By using genome information to create tools for perturbing gene function, it is now possible to undertake systematic genome-wide functional screens that examine the contribution of every gene to a biological process. The directed nature of these experiments contrasts with traditional methods, in which random mutations are induced and the resulting mutants are screened for various phenotypes. The first genome-wide functional screens in Caenorhabditis elegans and Drosophila melanogaster have recently been published, and screens in human cells will soon follow. These high-throughput techniques promise the rapid annotation of genomes with high-quality information about the biological function of each gene. More... »

PAGES

11-22

References to SciGraph publications

  • 2003-08. Loss of the cylindromatosis tumour suppressor inhibits apoptosis by activating NF-κB in NATURE
  • 2000-11. Functional genomic analysis of cell division in C. elegans using RNAi of genes on chromosome III in NATURE
  • 2001-12. Genes required for ionizing radiation resistance in yeast in NATURE GENETICS
  • 2003-10. Global analysis of protein localization in budding yeast in NATURE
  • 2002-07. RNA interference in NATURE
  • 2003-06. Functional proteomic identification of DNA replication proteins by induced proteolysis in vivo in NATURE
  • 2002-09. Treasures and traps in genome-wide data sets: case examples from yeast in NATURE REVIEWS GENETICS
  • 2003-01. Systematic functional analysis of the Caenorhabditis elegans genome using RNAi in NATURE
  • 1999-11. Large-scale analysis of the yeast genome by transposon tagging and gene disruption in NATURE
  • 2003-06. Expression profiling reveals off-target gene regulation by RNAi in NATURE BIOTECHNOLOGY
  • 2002-11. Arrayed adenoviral expression libraries for functional screening in NATURE BIOTECHNOLOGY
  • 2003-01. Role of duplicate genes in genetic robustness against null mutations in NATURE
  • 2003-05. C. elegans ORFeome version 1.1: experimental verification of the genome annotation and resource for proteome-scale protein expression in NATURE GENETICS
  • 2003-01. Genome-wide RNAi analysis of Caenorhabditis elegans fat regulatory genes in NATURE
  • 2002-07. Functional profiling of the Saccharomyces cerevisiae genome in NATURE
  • 2003-06. Whither RNAi? in NATURE CELL BIOLOGY
  • 2001-05. The flexible genome in NATURE REVIEWS GENETICS
  • 2000-02. Heritable and inducible genetic interference by double-stranded RNA encoded by transgenes in NATURE GENETICS
  • 1998-02. Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans in NATURE
  • 2000-01. Effectiveness of specific RNA-mediated interference through ingested double-stranded RNA in Caenorhabditis elegans in GENOME BIOLOGY
  • 1999-11. A combined algorithm for genome-wide prediction of protein function in NATURE
  • 2002-03. From sequence to phenotype: reverse genetics in drosophila melanogaster in NATURE REVIEWS GENETICS
  • 2003-03. An epi-allelic series of p53 hypomorphs created by stable RNAi produces distinct tumor phenotypes in vivo in NATURE GENETICS
  • 2002-08. Systematic screen for human disease genes in yeast in NATURE GENETICS
  • 2001-05. Microarrays of cells expressing defined cDNAs in NATURE
  • 2003-06. Killing the messenger: short RNAs that silence gene expression in NATURE REVIEWS MOLECULAR CELL BIOLOGY
  • 2002-12. Annotation of the Drosophila melanogastereuchromatic genome: a systematic review in GENOME BIOLOGY
  • 2003-03. TIP, a T-cell factor identified using high-throughput screening increases survival in a graft-versus-host disease model in NATURE BIOTECHNOLOGY
  • 2003-03. An integrated functional genomics screening program reveals a role for BMP-9 in glucose homeostasis in NATURE BIOTECHNOLOGY
  • 2003-12. A functional genomic analysis of cell morphology using RNA interference in BMC BIOLOGY
  • 2003-10. Global analysis of protein expression in yeast in NATURE
  • 2003-03. A lentivirus-based system to functionally silence genes in primary mammalian cells, stem cells and transgenic mice by RNA interference in NATURE GENETICS
  • 2002-10. Gene silencing in mammals by small interfering RNAs in NATURE REVIEWS GENETICS
  • 2003-01. A systematic RNAi screen identifies a critical role for mitochondria in C. elegans longevity in NATURE GENETICS
  • 2001-07. Genome annotation: from sequence to biology in NATURE REVIEWS GENETICS
  • 2000-11. Functional genomic analysis of C. elegans chromosome I by systematic RNA interference in NATURE
  • 2002-05. Comparative assessment of large-scale data sets of protein–protein interactions in NATURE
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nrg1248

    DOI

    http://dx.doi.org/10.1038/nrg1248

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1025963446

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/14708012


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0604", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Genetics", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Biological Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Animals", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Caenorhabditis elegans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Drosophila melanogaster", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Genes, Reporter", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Genetic Techniques", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Genome", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Genome, Fungal", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Genome, Human", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Genomics", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Mutation", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Phenotype", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "RNA Interference", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Recombination, Genetic", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Saccharomyces cerevisiae", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Massachusetts Institute of Technology", 
              "id": "https://www.grid.ac/institutes/grid.116068.8", 
              "name": [
                "Whitehead Institute for Biomedical Research, MIT Department of Biology, 9 Cambridge Center, Cambridge, Massachusetts 02142, USA."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Carpenter", 
            "givenName": "Anne E", 
            "id": "sg:person.01273531723.70", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01273531723.70"
            ], 
            "type": "Person"
          }, 
          {
            "familyName": "Sabatini", 
            "givenName": "David M", 
            "id": "sg:person.013707532037.68", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013707532037.68"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "https://doi.org/10.1128/ec.1.5.799-810.2002", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001552802"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature01692", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002035791", 
              "https://doi.org/10.1038/nature01692"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature01692", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002035791", 
              "https://doi.org/10.1038/nature01692"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrg908", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003050911", 
              "https://doi.org/10.1038/nrg908"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrg908", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003050911", 
              "https://doi.org/10.1038/nrg908"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0960-9822(03)00577-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003428795"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0960-9822(03)00577-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003428795"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0168-9525(02)00005-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003526429"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0168-9525(02)00005-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003526429"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.240444197", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004063493"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gad.970902", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004289431"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1475-4924-2-27", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005000646", 
              "https://doi.org/10.1186/1475-4924-2-27"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrg886", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005073965", 
              "https://doi.org/10.1038/nrg886"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrg886", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005073965", 
              "https://doi.org/10.1038/nrg886"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/mcp.m100024-mcp200", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006074956"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1046-2023(03)00050-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006683863"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1046-2023(03)00050-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006683863"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1046-2023(03)00050-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006683863"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/35080529", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007510658", 
              "https://doi.org/10.1038/35080529"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/35080529", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007510658", 
              "https://doi.org/10.1038/35080529"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0960-9822(03)00539-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007706343"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0960-9822(03)00539-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007706343"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/gb-2002-3-12-research0083", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010099513", 
              "https://doi.org/10.1186/gb-2002-3-12-research0083"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.96.15.8567", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011290850"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/35075114", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011603691", 
              "https://doi.org/10.1038/35075114"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/35075114", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011603691", 
              "https://doi.org/10.1038/35075114"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature01279", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012319114", 
              "https://doi.org/10.1038/nature01279"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature01279", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012319114", 
              "https://doi.org/10.1038/nature01279"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/gb-2000-2-1-research0002", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012457949", 
              "https://doi.org/10.1186/gb-2000-2-1-research0002"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/72850", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015018717", 
              "https://doi.org/10.1038/72850"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/72850", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015018717", 
              "https://doi.org/10.1038/72850"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng778", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015080327", 
              "https://doi.org/10.1038/ng778"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng778", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015080327", 
              "https://doi.org/10.1038/ng778"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature00935", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015995329", 
              "https://doi.org/10.1038/nature00935"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature00935", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015995329", 
              "https://doi.org/10.1038/nature00935"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature02046", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016490499", 
              "https://doi.org/10.1038/nature02046"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature02046", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016490499", 
              "https://doi.org/10.1038/nature02046"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0962-8924(01)01928-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017643613"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature750", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017837373", 
              "https://doi.org/10.1038/nature750"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature750", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017837373", 
              "https://doi.org/10.1038/nature750"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0076-6879(02)50972-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018053366"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.0530118100", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018208790"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/35888", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018713804", 
              "https://doi.org/10.1038/35888"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/35888", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018713804", 
              "https://doi.org/10.1038/35888"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/yea.784", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019215252"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1367-5931(01)00277-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019355843"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nbt746", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019535289", 
              "https://doi.org/10.1038/nbt746"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nbt746", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019535289", 
              "https://doi.org/10.1038/nbt746"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1097-2765(02)00541-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019720069"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nbt831", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021890587", 
              "https://doi.org/10.1038/nbt831"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nbt831", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021890587", 
              "https://doi.org/10.1038/nbt831"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nbt795", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022753691", 
              "https://doi.org/10.1038/nbt795"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nbt795", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022753691", 
              "https://doi.org/10.1038/nbt795"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1091/mbc.01-12-0588", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022900373"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gad.1060703", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022941124"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1086391", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023690602"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1083/jcb.200303023", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024033927"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.202604399", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024176882"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncb0603-490", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024410925", 
              "https://doi.org/10.1038/ncb0603-490"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncb0603-490", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024410925", 
              "https://doi.org/10.1038/ncb0603-490"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.273.39.25000", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024972810"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng1140", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025386868", 
              "https://doi.org/10.1038/ng1140"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng1140", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025386868", 
              "https://doi.org/10.1038/ng1140"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature02026", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026526651", 
              "https://doi.org/10.1038/nature02026"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature02026", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026526651", 
              "https://doi.org/10.1038/nature02026"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature01811", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026687985", 
              "https://doi.org/10.1038/nature01811"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature01811", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026687985", 
              "https://doi.org/10.1038/nature01811"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1074-5521(03)00108-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027474889"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1074-5521(03)00108-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027474889"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/47048", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029164285", 
              "https://doi.org/10.1038/47048"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/47048", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029164285", 
              "https://doi.org/10.1038/47048"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1091/mbc.12.7.2147", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029187138"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1070850", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029353447"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.262669299", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029380231"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1083/jcb.200303022", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029745734"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pbio.0000012", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030230900"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.1934839100", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030805000"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature01278", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031657596", 
              "https://doi.org/10.1038/nature01278"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature01278", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031657596", 
              "https://doi.org/10.1038/nature01278"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0378-1097(03)00384-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032356924"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.285.5429.901", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032829879"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0092-8674(03)00315-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033242585"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nbt797", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033783050", 
              "https://doi.org/10.1038/nbt797"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nbt797", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033783050", 
              "https://doi.org/10.1038/nbt797"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1087117", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033896311"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/35042517", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034980685", 
              "https://doi.org/10.1038/35042517"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/35042517", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034980685", 
              "https://doi.org/10.1038/35042517"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/418244a", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035887015", 
              "https://doi.org/10.1038/418244a"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/418244a", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035887015", 
              "https://doi.org/10.1038/418244a"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/418244a", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035887015", 
              "https://doi.org/10.1038/418244a"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0962-8924(03)00127-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035962228"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0962-8924(03)00127-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035962228"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrm1129", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036681159", 
              "https://doi.org/10.1038/nrm1129"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrm1129", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036681159", 
              "https://doi.org/10.1038/nrm1129"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/35072018", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037147561", 
              "https://doi.org/10.1038/35072018"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/35072018", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037147561", 
              "https://doi.org/10.1038/35072018"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng1091", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038006549", 
              "https://doi.org/10.1038/ng1091"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng1091", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038006549", 
              "https://doi.org/10.1038/ng1091"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1177/108705719900400206", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038278323"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1177/108705719900400206", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038278323"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng929", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038368313", 
              "https://doi.org/10.1038/ng929"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng929", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038368313", 
              "https://doi.org/10.1038/ng929"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0960-9822(02)01305-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039410737"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0960-9822(02)01305-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039410737"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1091/mbc.02-01-0005", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039967170"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.1932773100", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040251945"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0092-8674(01)00221-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041407912"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1097-2765(03)00348-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042168156"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/35042526", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042500597", 
              "https://doi.org/10.1038/35042526"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/35042526", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042500597", 
              "https://doi.org/10.1038/35042526"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrg752", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042964541", 
              "https://doi.org/10.1038/nrg752"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrg752", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042964541", 
              "https://doi.org/10.1038/nrg752"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gr.1575003", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043243394"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/yea.726", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043428761"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0959-437x(02)00290-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044004206"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m111433200", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045102328"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature01198", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045109836", 
              "https://doi.org/10.1038/nature01198"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature01198", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045109836", 
              "https://doi.org/10.1038/nature01198"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.152264899", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045500294"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.molcel.2003.08.013", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045933221"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.molcel.2003.08.013", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045933221"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/mcb.23.12.4207-4218.2003", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046770843"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng1056", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047240808", 
              "https://doi.org/10.1038/ng1056"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng1056", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047240808", 
              "https://doi.org/10.1038/ng1056"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/46558", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048366482", 
              "https://doi.org/10.1038/46558"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/46558", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048366482", 
              "https://doi.org/10.1038/46558"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng1117", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048907095", 
              "https://doi.org/10.1038/ng1117"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng1117", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048907095", 
              "https://doi.org/10.1038/ng1117"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gad.1073003", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049351259"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1065810", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050273151"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.231366398", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050277573"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/mcb.22.14.5076-5088.2002", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050293288"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m303300200", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050965078"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0960-9822(01)00052-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051339729"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1091/mbc.e02-08-0456", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052383632"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gr.1478703", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053428282"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1065672", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062445529"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1069981", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062445974"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1081403", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062447838"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1082602", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062447946"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1084354", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062448098"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.291.5506.1001", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062572887"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1667/rr3019", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1068196061"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1075237995", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1075259822", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1075271988", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1082926612", 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2004-01", 
        "datePublishedReg": "2004-01-01", 
        "description": "By using genome information to create tools for perturbing gene function, it is now possible to undertake systematic genome-wide functional screens that examine the contribution of every gene to a biological process. The directed nature of these experiments contrasts with traditional methods, in which random mutations are induced and the resulting mutants are screened for various phenotypes. The first genome-wide functional screens in Caenorhabditis elegans and Drosophila melanogaster have recently been published, and screens in human cells will soon follow. These high-throughput techniques promise the rapid annotation of genomes with high-quality information about the biological function of each gene.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1038/nrg1248", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": false, 
        "isPartOf": [
          {
            "id": "sg:journal.1023607", 
            "issn": [
              "1471-0056", 
              "1471-0064"
            ], 
            "name": "Nature Reviews Genetics", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "1", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "5"
          }
        ], 
        "name": "Systematic genome-wide screens of gene function", 
        "pagination": "11-22", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "7bb0988f355496cfc9a4a901aa4b7003c8df0e8d2c69d3f9401c04f4e772cc40"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "14708012"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "100962779"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1038/nrg1248"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1025963446"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1038/nrg1248", 
          "https://app.dimensions.ai/details/publication/pub.1025963446"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-11T11:53", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000359_0000000359/records_29197_00000001.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "http://www.nature.com/nrg/journal/v5/n1/full/nrg1248.html"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/nrg1248'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/nrg1248'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/nrg1248'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/nrg1248'


     

    This table displays all metadata directly associated to this object as RDF triples.

    474 TRIPLES      21 PREDICATES      146 URIs      36 LITERALS      24 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1038/nrg1248 schema:about N1089082ed2f0474ca6869e68a07ef5f4
    2 N19042fac847e4e4e97bfedaed9ca3396
    3 N241b8dce27424012bbfa0ff00a3d3a36
    4 N2553e448754e420297e4b86de8b51762
    5 N30ce3834698640518b586af73b395302
    6 N4cee215e73784b62be05f4814c9124b4
    7 N616ac1951d75445984c734990409d2d3
    8 N6c291e9e3f7f4de0a3021d9b7a183039
    9 N764cb76c64094d4fb5e8542b4b66b17a
    10 N8c25568db26b48919c4f47aa3cb152f4
    11 N990d9025fae04ef4ba8799e77ab6ee5c
    12 N9ae23635b66a4093ae0f8d6222068506
    13 Nae2460a27cee4c93a35af95ceaecb58d
    14 Nbe9fcc3be2c24c4887649f253366eb4d
    15 Ne15831bd97f94a168d8a93f7d3d5876f
    16 anzsrc-for:06
    17 anzsrc-for:0604
    18 schema:author N21068725caf242a1987dc6988dcaeec9
    19 schema:citation sg:pub.10.1038/35042517
    20 sg:pub.10.1038/35042526
    21 sg:pub.10.1038/35072018
    22 sg:pub.10.1038/35075114
    23 sg:pub.10.1038/35080529
    24 sg:pub.10.1038/35888
    25 sg:pub.10.1038/418244a
    26 sg:pub.10.1038/46558
    27 sg:pub.10.1038/47048
    28 sg:pub.10.1038/72850
    29 sg:pub.10.1038/nature00935
    30 sg:pub.10.1038/nature01198
    31 sg:pub.10.1038/nature01278
    32 sg:pub.10.1038/nature01279
    33 sg:pub.10.1038/nature01692
    34 sg:pub.10.1038/nature01811
    35 sg:pub.10.1038/nature02026
    36 sg:pub.10.1038/nature02046
    37 sg:pub.10.1038/nature750
    38 sg:pub.10.1038/nbt746
    39 sg:pub.10.1038/nbt795
    40 sg:pub.10.1038/nbt797
    41 sg:pub.10.1038/nbt831
    42 sg:pub.10.1038/ncb0603-490
    43 sg:pub.10.1038/ng1056
    44 sg:pub.10.1038/ng1091
    45 sg:pub.10.1038/ng1117
    46 sg:pub.10.1038/ng1140
    47 sg:pub.10.1038/ng778
    48 sg:pub.10.1038/ng929
    49 sg:pub.10.1038/nrg752
    50 sg:pub.10.1038/nrg886
    51 sg:pub.10.1038/nrg908
    52 sg:pub.10.1038/nrm1129
    53 sg:pub.10.1186/1475-4924-2-27
    54 sg:pub.10.1186/gb-2000-2-1-research0002
    55 sg:pub.10.1186/gb-2002-3-12-research0083
    56 https://app.dimensions.ai/details/publication/pub.1075237995
    57 https://app.dimensions.ai/details/publication/pub.1075259822
    58 https://app.dimensions.ai/details/publication/pub.1075271988
    59 https://app.dimensions.ai/details/publication/pub.1082926612
    60 https://doi.org/10.1002/yea.726
    61 https://doi.org/10.1002/yea.784
    62 https://doi.org/10.1016/j.molcel.2003.08.013
    63 https://doi.org/10.1016/s0076-6879(02)50972-1
    64 https://doi.org/10.1016/s0092-8674(01)00221-5
    65 https://doi.org/10.1016/s0092-8674(03)00315-5
    66 https://doi.org/10.1016/s0168-9525(02)00005-7
    67 https://doi.org/10.1016/s0378-1097(03)00384-7
    68 https://doi.org/10.1016/s0959-437x(02)00290-3
    69 https://doi.org/10.1016/s0960-9822(01)00052-5
    70 https://doi.org/10.1016/s0960-9822(02)01305-2
    71 https://doi.org/10.1016/s0960-9822(03)00539-6
    72 https://doi.org/10.1016/s0960-9822(03)00577-3
    73 https://doi.org/10.1016/s0962-8924(01)01928-6
    74 https://doi.org/10.1016/s0962-8924(03)00127-2
    75 https://doi.org/10.1016/s1046-2023(03)00050-1
    76 https://doi.org/10.1016/s1074-5521(03)00108-x
    77 https://doi.org/10.1016/s1097-2765(02)00541-5
    78 https://doi.org/10.1016/s1097-2765(03)00348-4
    79 https://doi.org/10.1016/s1367-5931(01)00277-0
    80 https://doi.org/10.1073/pnas.0530118100
    81 https://doi.org/10.1073/pnas.152264899
    82 https://doi.org/10.1073/pnas.1932773100
    83 https://doi.org/10.1073/pnas.1934839100
    84 https://doi.org/10.1073/pnas.202604399
    85 https://doi.org/10.1073/pnas.231366398
    86 https://doi.org/10.1073/pnas.240444197
    87 https://doi.org/10.1073/pnas.262669299
    88 https://doi.org/10.1073/pnas.96.15.8567
    89 https://doi.org/10.1074/jbc.273.39.25000
    90 https://doi.org/10.1074/jbc.m111433200
    91 https://doi.org/10.1074/jbc.m303300200
    92 https://doi.org/10.1074/mcp.m100024-mcp200
    93 https://doi.org/10.1083/jcb.200303022
    94 https://doi.org/10.1083/jcb.200303023
    95 https://doi.org/10.1091/mbc.01-12-0588
    96 https://doi.org/10.1091/mbc.02-01-0005
    97 https://doi.org/10.1091/mbc.12.7.2147
    98 https://doi.org/10.1091/mbc.e02-08-0456
    99 https://doi.org/10.1101/gad.1060703
    100 https://doi.org/10.1101/gad.1073003
    101 https://doi.org/10.1101/gad.970902
    102 https://doi.org/10.1101/gr.1478703
    103 https://doi.org/10.1101/gr.1575003
    104 https://doi.org/10.1126/science.1065672
    105 https://doi.org/10.1126/science.1065810
    106 https://doi.org/10.1126/science.1069981
    107 https://doi.org/10.1126/science.1070850
    108 https://doi.org/10.1126/science.1081403
    109 https://doi.org/10.1126/science.1082602
    110 https://doi.org/10.1126/science.1084354
    111 https://doi.org/10.1126/science.1086391
    112 https://doi.org/10.1126/science.1087117
    113 https://doi.org/10.1126/science.285.5429.901
    114 https://doi.org/10.1126/science.291.5506.1001
    115 https://doi.org/10.1128/ec.1.5.799-810.2002
    116 https://doi.org/10.1128/mcb.22.14.5076-5088.2002
    117 https://doi.org/10.1128/mcb.23.12.4207-4218.2003
    118 https://doi.org/10.1177/108705719900400206
    119 https://doi.org/10.1371/journal.pbio.0000012
    120 https://doi.org/10.1667/rr3019
    121 schema:datePublished 2004-01
    122 schema:datePublishedReg 2004-01-01
    123 schema:description By using genome information to create tools for perturbing gene function, it is now possible to undertake systematic genome-wide functional screens that examine the contribution of every gene to a biological process. The directed nature of these experiments contrasts with traditional methods, in which random mutations are induced and the resulting mutants are screened for various phenotypes. The first genome-wide functional screens in Caenorhabditis elegans and Drosophila melanogaster have recently been published, and screens in human cells will soon follow. These high-throughput techniques promise the rapid annotation of genomes with high-quality information about the biological function of each gene.
    124 schema:genre research_article
    125 schema:inLanguage en
    126 schema:isAccessibleForFree false
    127 schema:isPartOf N64b1deef6ee643e9a72d31c37ebbc218
    128 Nd8490406244f4e35965e3ee019fc9fbe
    129 sg:journal.1023607
    130 schema:name Systematic genome-wide screens of gene function
    131 schema:pagination 11-22
    132 schema:productId N36dc311096d940798f2f73c3cbc36dbd
    133 N42142807d246452397db076d1997d488
    134 N7fc59da9837b445d8e380676102da763
    135 N88e9b78887de4936ab697d32603cd522
    136 N96901b80acec40a79d6445d0036160e3
    137 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025963446
    138 https://doi.org/10.1038/nrg1248
    139 schema:sdDatePublished 2019-04-11T11:53
    140 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    141 schema:sdPublisher Naaa71bfa021c42d2a83908735fc2845a
    142 schema:url http://www.nature.com/nrg/journal/v5/n1/full/nrg1248.html
    143 sgo:license sg:explorer/license/
    144 sgo:sdDataset articles
    145 rdf:type schema:ScholarlyArticle
    146 N1089082ed2f0474ca6869e68a07ef5f4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    147 schema:name Genome
    148 rdf:type schema:DefinedTerm
    149 N172d9213f0aa4e1fa18db688de0144c7 rdf:first sg:person.013707532037.68
    150 rdf:rest rdf:nil
    151 N19042fac847e4e4e97bfedaed9ca3396 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    152 schema:name Caenorhabditis elegans
    153 rdf:type schema:DefinedTerm
    154 N21068725caf242a1987dc6988dcaeec9 rdf:first sg:person.01273531723.70
    155 rdf:rest N172d9213f0aa4e1fa18db688de0144c7
    156 N241b8dce27424012bbfa0ff00a3d3a36 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    157 schema:name Genomics
    158 rdf:type schema:DefinedTerm
    159 N2553e448754e420297e4b86de8b51762 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    160 schema:name Saccharomyces cerevisiae
    161 rdf:type schema:DefinedTerm
    162 N30ce3834698640518b586af73b395302 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    163 schema:name Genome, Fungal
    164 rdf:type schema:DefinedTerm
    165 N36dc311096d940798f2f73c3cbc36dbd schema:name doi
    166 schema:value 10.1038/nrg1248
    167 rdf:type schema:PropertyValue
    168 N42142807d246452397db076d1997d488 schema:name pubmed_id
    169 schema:value 14708012
    170 rdf:type schema:PropertyValue
    171 N4cee215e73784b62be05f4814c9124b4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    172 schema:name Recombination, Genetic
    173 rdf:type schema:DefinedTerm
    174 N616ac1951d75445984c734990409d2d3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    175 schema:name Genetic Techniques
    176 rdf:type schema:DefinedTerm
    177 N64b1deef6ee643e9a72d31c37ebbc218 schema:issueNumber 1
    178 rdf:type schema:PublicationIssue
    179 N6c291e9e3f7f4de0a3021d9b7a183039 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    180 schema:name Phenotype
    181 rdf:type schema:DefinedTerm
    182 N764cb76c64094d4fb5e8542b4b66b17a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    183 schema:name Animals
    184 rdf:type schema:DefinedTerm
    185 N7fc59da9837b445d8e380676102da763 schema:name nlm_unique_id
    186 schema:value 100962779
    187 rdf:type schema:PropertyValue
    188 N88e9b78887de4936ab697d32603cd522 schema:name readcube_id
    189 schema:value 7bb0988f355496cfc9a4a901aa4b7003c8df0e8d2c69d3f9401c04f4e772cc40
    190 rdf:type schema:PropertyValue
    191 N8c25568db26b48919c4f47aa3cb152f4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    192 schema:name Mutation
    193 rdf:type schema:DefinedTerm
    194 N96901b80acec40a79d6445d0036160e3 schema:name dimensions_id
    195 schema:value pub.1025963446
    196 rdf:type schema:PropertyValue
    197 N990d9025fae04ef4ba8799e77ab6ee5c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    198 schema:name Genome, Human
    199 rdf:type schema:DefinedTerm
    200 N9ae23635b66a4093ae0f8d6222068506 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    201 schema:name RNA Interference
    202 rdf:type schema:DefinedTerm
    203 Naaa71bfa021c42d2a83908735fc2845a schema:name Springer Nature - SN SciGraph project
    204 rdf:type schema:Organization
    205 Nae2460a27cee4c93a35af95ceaecb58d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    206 schema:name Genes, Reporter
    207 rdf:type schema:DefinedTerm
    208 Nbe9fcc3be2c24c4887649f253366eb4d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    209 schema:name Drosophila melanogaster
    210 rdf:type schema:DefinedTerm
    211 Nd8490406244f4e35965e3ee019fc9fbe schema:volumeNumber 5
    212 rdf:type schema:PublicationVolume
    213 Ne15831bd97f94a168d8a93f7d3d5876f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    214 schema:name Humans
    215 rdf:type schema:DefinedTerm
    216 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
    217 schema:name Biological Sciences
    218 rdf:type schema:DefinedTerm
    219 anzsrc-for:0604 schema:inDefinedTermSet anzsrc-for:
    220 schema:name Genetics
    221 rdf:type schema:DefinedTerm
    222 sg:journal.1023607 schema:issn 1471-0056
    223 1471-0064
    224 schema:name Nature Reviews Genetics
    225 rdf:type schema:Periodical
    226 sg:person.01273531723.70 schema:affiliation https://www.grid.ac/institutes/grid.116068.8
    227 schema:familyName Carpenter
    228 schema:givenName Anne E
    229 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01273531723.70
    230 rdf:type schema:Person
    231 sg:person.013707532037.68 schema:familyName Sabatini
    232 schema:givenName David M
    233 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013707532037.68
    234 rdf:type schema:Person
    235 sg:pub.10.1038/35042517 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034980685
    236 https://doi.org/10.1038/35042517
    237 rdf:type schema:CreativeWork
    238 sg:pub.10.1038/35042526 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042500597
    239 https://doi.org/10.1038/35042526
    240 rdf:type schema:CreativeWork
    241 sg:pub.10.1038/35072018 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037147561
    242 https://doi.org/10.1038/35072018
    243 rdf:type schema:CreativeWork
    244 sg:pub.10.1038/35075114 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011603691
    245 https://doi.org/10.1038/35075114
    246 rdf:type schema:CreativeWork
    247 sg:pub.10.1038/35080529 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007510658
    248 https://doi.org/10.1038/35080529
    249 rdf:type schema:CreativeWork
    250 sg:pub.10.1038/35888 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018713804
    251 https://doi.org/10.1038/35888
    252 rdf:type schema:CreativeWork
    253 sg:pub.10.1038/418244a schema:sameAs https://app.dimensions.ai/details/publication/pub.1035887015
    254 https://doi.org/10.1038/418244a
    255 rdf:type schema:CreativeWork
    256 sg:pub.10.1038/46558 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048366482
    257 https://doi.org/10.1038/46558
    258 rdf:type schema:CreativeWork
    259 sg:pub.10.1038/47048 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029164285
    260 https://doi.org/10.1038/47048
    261 rdf:type schema:CreativeWork
    262 sg:pub.10.1038/72850 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015018717
    263 https://doi.org/10.1038/72850
    264 rdf:type schema:CreativeWork
    265 sg:pub.10.1038/nature00935 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015995329
    266 https://doi.org/10.1038/nature00935
    267 rdf:type schema:CreativeWork
    268 sg:pub.10.1038/nature01198 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045109836
    269 https://doi.org/10.1038/nature01198
    270 rdf:type schema:CreativeWork
    271 sg:pub.10.1038/nature01278 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031657596
    272 https://doi.org/10.1038/nature01278
    273 rdf:type schema:CreativeWork
    274 sg:pub.10.1038/nature01279 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012319114
    275 https://doi.org/10.1038/nature01279
    276 rdf:type schema:CreativeWork
    277 sg:pub.10.1038/nature01692 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002035791
    278 https://doi.org/10.1038/nature01692
    279 rdf:type schema:CreativeWork
    280 sg:pub.10.1038/nature01811 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026687985
    281 https://doi.org/10.1038/nature01811
    282 rdf:type schema:CreativeWork
    283 sg:pub.10.1038/nature02026 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026526651
    284 https://doi.org/10.1038/nature02026
    285 rdf:type schema:CreativeWork
    286 sg:pub.10.1038/nature02046 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016490499
    287 https://doi.org/10.1038/nature02046
    288 rdf:type schema:CreativeWork
    289 sg:pub.10.1038/nature750 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017837373
    290 https://doi.org/10.1038/nature750
    291 rdf:type schema:CreativeWork
    292 sg:pub.10.1038/nbt746 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019535289
    293 https://doi.org/10.1038/nbt746
    294 rdf:type schema:CreativeWork
    295 sg:pub.10.1038/nbt795 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022753691
    296 https://doi.org/10.1038/nbt795
    297 rdf:type schema:CreativeWork
    298 sg:pub.10.1038/nbt797 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033783050
    299 https://doi.org/10.1038/nbt797
    300 rdf:type schema:CreativeWork
    301 sg:pub.10.1038/nbt831 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021890587
    302 https://doi.org/10.1038/nbt831
    303 rdf:type schema:CreativeWork
    304 sg:pub.10.1038/ncb0603-490 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024410925
    305 https://doi.org/10.1038/ncb0603-490
    306 rdf:type schema:CreativeWork
    307 sg:pub.10.1038/ng1056 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047240808
    308 https://doi.org/10.1038/ng1056
    309 rdf:type schema:CreativeWork
    310 sg:pub.10.1038/ng1091 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038006549
    311 https://doi.org/10.1038/ng1091
    312 rdf:type schema:CreativeWork
    313 sg:pub.10.1038/ng1117 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048907095
    314 https://doi.org/10.1038/ng1117
    315 rdf:type schema:CreativeWork
    316 sg:pub.10.1038/ng1140 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025386868
    317 https://doi.org/10.1038/ng1140
    318 rdf:type schema:CreativeWork
    319 sg:pub.10.1038/ng778 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015080327
    320 https://doi.org/10.1038/ng778
    321 rdf:type schema:CreativeWork
    322 sg:pub.10.1038/ng929 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038368313
    323 https://doi.org/10.1038/ng929
    324 rdf:type schema:CreativeWork
    325 sg:pub.10.1038/nrg752 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042964541
    326 https://doi.org/10.1038/nrg752
    327 rdf:type schema:CreativeWork
    328 sg:pub.10.1038/nrg886 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005073965
    329 https://doi.org/10.1038/nrg886
    330 rdf:type schema:CreativeWork
    331 sg:pub.10.1038/nrg908 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003050911
    332 https://doi.org/10.1038/nrg908
    333 rdf:type schema:CreativeWork
    334 sg:pub.10.1038/nrm1129 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036681159
    335 https://doi.org/10.1038/nrm1129
    336 rdf:type schema:CreativeWork
    337 sg:pub.10.1186/1475-4924-2-27 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005000646
    338 https://doi.org/10.1186/1475-4924-2-27
    339 rdf:type schema:CreativeWork
    340 sg:pub.10.1186/gb-2000-2-1-research0002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012457949
    341 https://doi.org/10.1186/gb-2000-2-1-research0002
    342 rdf:type schema:CreativeWork
    343 sg:pub.10.1186/gb-2002-3-12-research0083 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010099513
    344 https://doi.org/10.1186/gb-2002-3-12-research0083
    345 rdf:type schema:CreativeWork
    346 https://app.dimensions.ai/details/publication/pub.1075237995 schema:CreativeWork
    347 https://app.dimensions.ai/details/publication/pub.1075259822 schema:CreativeWork
    348 https://app.dimensions.ai/details/publication/pub.1075271988 schema:CreativeWork
    349 https://app.dimensions.ai/details/publication/pub.1082926612 schema:CreativeWork
    350 https://doi.org/10.1002/yea.726 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043428761
    351 rdf:type schema:CreativeWork
    352 https://doi.org/10.1002/yea.784 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019215252
    353 rdf:type schema:CreativeWork
    354 https://doi.org/10.1016/j.molcel.2003.08.013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045933221
    355 rdf:type schema:CreativeWork
    356 https://doi.org/10.1016/s0076-6879(02)50972-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018053366
    357 rdf:type schema:CreativeWork
    358 https://doi.org/10.1016/s0092-8674(01)00221-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041407912
    359 rdf:type schema:CreativeWork
    360 https://doi.org/10.1016/s0092-8674(03)00315-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033242585
    361 rdf:type schema:CreativeWork
    362 https://doi.org/10.1016/s0168-9525(02)00005-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003526429
    363 rdf:type schema:CreativeWork
    364 https://doi.org/10.1016/s0378-1097(03)00384-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032356924
    365 rdf:type schema:CreativeWork
    366 https://doi.org/10.1016/s0959-437x(02)00290-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044004206
    367 rdf:type schema:CreativeWork
    368 https://doi.org/10.1016/s0960-9822(01)00052-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051339729
    369 rdf:type schema:CreativeWork
    370 https://doi.org/10.1016/s0960-9822(02)01305-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039410737
    371 rdf:type schema:CreativeWork
    372 https://doi.org/10.1016/s0960-9822(03)00539-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007706343
    373 rdf:type schema:CreativeWork
    374 https://doi.org/10.1016/s0960-9822(03)00577-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003428795
    375 rdf:type schema:CreativeWork
    376 https://doi.org/10.1016/s0962-8924(01)01928-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017643613
    377 rdf:type schema:CreativeWork
    378 https://doi.org/10.1016/s0962-8924(03)00127-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035962228
    379 rdf:type schema:CreativeWork
    380 https://doi.org/10.1016/s1046-2023(03)00050-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006683863
    381 rdf:type schema:CreativeWork
    382 https://doi.org/10.1016/s1074-5521(03)00108-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1027474889
    383 rdf:type schema:CreativeWork
    384 https://doi.org/10.1016/s1097-2765(02)00541-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019720069
    385 rdf:type schema:CreativeWork
    386 https://doi.org/10.1016/s1097-2765(03)00348-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042168156
    387 rdf:type schema:CreativeWork
    388 https://doi.org/10.1016/s1367-5931(01)00277-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019355843
    389 rdf:type schema:CreativeWork
    390 https://doi.org/10.1073/pnas.0530118100 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018208790
    391 rdf:type schema:CreativeWork
    392 https://doi.org/10.1073/pnas.152264899 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045500294
    393 rdf:type schema:CreativeWork
    394 https://doi.org/10.1073/pnas.1932773100 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040251945
    395 rdf:type schema:CreativeWork
    396 https://doi.org/10.1073/pnas.1934839100 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030805000
    397 rdf:type schema:CreativeWork
    398 https://doi.org/10.1073/pnas.202604399 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024176882
    399 rdf:type schema:CreativeWork
    400 https://doi.org/10.1073/pnas.231366398 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050277573
    401 rdf:type schema:CreativeWork
    402 https://doi.org/10.1073/pnas.240444197 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004063493
    403 rdf:type schema:CreativeWork
    404 https://doi.org/10.1073/pnas.262669299 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029380231
    405 rdf:type schema:CreativeWork
    406 https://doi.org/10.1073/pnas.96.15.8567 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011290850
    407 rdf:type schema:CreativeWork
    408 https://doi.org/10.1074/jbc.273.39.25000 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024972810
    409 rdf:type schema:CreativeWork
    410 https://doi.org/10.1074/jbc.m111433200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045102328
    411 rdf:type schema:CreativeWork
    412 https://doi.org/10.1074/jbc.m303300200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050965078
    413 rdf:type schema:CreativeWork
    414 https://doi.org/10.1074/mcp.m100024-mcp200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006074956
    415 rdf:type schema:CreativeWork
    416 https://doi.org/10.1083/jcb.200303022 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029745734
    417 rdf:type schema:CreativeWork
    418 https://doi.org/10.1083/jcb.200303023 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024033927
    419 rdf:type schema:CreativeWork
    420 https://doi.org/10.1091/mbc.01-12-0588 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022900373
    421 rdf:type schema:CreativeWork
    422 https://doi.org/10.1091/mbc.02-01-0005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039967170
    423 rdf:type schema:CreativeWork
    424 https://doi.org/10.1091/mbc.12.7.2147 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029187138
    425 rdf:type schema:CreativeWork
    426 https://doi.org/10.1091/mbc.e02-08-0456 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052383632
    427 rdf:type schema:CreativeWork
    428 https://doi.org/10.1101/gad.1060703 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022941124
    429 rdf:type schema:CreativeWork
    430 https://doi.org/10.1101/gad.1073003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049351259
    431 rdf:type schema:CreativeWork
    432 https://doi.org/10.1101/gad.970902 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004289431
    433 rdf:type schema:CreativeWork
    434 https://doi.org/10.1101/gr.1478703 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053428282
    435 rdf:type schema:CreativeWork
    436 https://doi.org/10.1101/gr.1575003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043243394
    437 rdf:type schema:CreativeWork
    438 https://doi.org/10.1126/science.1065672 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062445529
    439 rdf:type schema:CreativeWork
    440 https://doi.org/10.1126/science.1065810 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050273151
    441 rdf:type schema:CreativeWork
    442 https://doi.org/10.1126/science.1069981 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062445974
    443 rdf:type schema:CreativeWork
    444 https://doi.org/10.1126/science.1070850 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029353447
    445 rdf:type schema:CreativeWork
    446 https://doi.org/10.1126/science.1081403 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062447838
    447 rdf:type schema:CreativeWork
    448 https://doi.org/10.1126/science.1082602 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062447946
    449 rdf:type schema:CreativeWork
    450 https://doi.org/10.1126/science.1084354 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062448098
    451 rdf:type schema:CreativeWork
    452 https://doi.org/10.1126/science.1086391 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023690602
    453 rdf:type schema:CreativeWork
    454 https://doi.org/10.1126/science.1087117 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033896311
    455 rdf:type schema:CreativeWork
    456 https://doi.org/10.1126/science.285.5429.901 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032829879
    457 rdf:type schema:CreativeWork
    458 https://doi.org/10.1126/science.291.5506.1001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062572887
    459 rdf:type schema:CreativeWork
    460 https://doi.org/10.1128/ec.1.5.799-810.2002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001552802
    461 rdf:type schema:CreativeWork
    462 https://doi.org/10.1128/mcb.22.14.5076-5088.2002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050293288
    463 rdf:type schema:CreativeWork
    464 https://doi.org/10.1128/mcb.23.12.4207-4218.2003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046770843
    465 rdf:type schema:CreativeWork
    466 https://doi.org/10.1177/108705719900400206 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038278323
    467 rdf:type schema:CreativeWork
    468 https://doi.org/10.1371/journal.pbio.0000012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030230900
    469 rdf:type schema:CreativeWork
    470 https://doi.org/10.1667/rr3019 schema:sameAs https://app.dimensions.ai/details/publication/pub.1068196061
    471 rdf:type schema:CreativeWork
    472 https://www.grid.ac/institutes/grid.116068.8 schema:alternateName Massachusetts Institute of Technology
    473 schema:name Whitehead Institute for Biomedical Research, MIT Department of Biology, 9 Cambridge Center, Cambridge, Massachusetts 02142, USA.
    474 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...