Blood vessels and nerves: common signals, pathways and diseases View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2003-09

AUTHORS

Peter Carmeliet

ABSTRACT

Key PointsThis article presents an overview of the emerging evidence of how neurons and blood vessels share common genetic pathways to acquire their fate, grow, pattern and navigate, and how both the vascular and neural systems are linked.Both neural and vascular progenitors use common genetic pathways to differentiate into specialized cell subtypes, all of which are optimally equipped to perform specific functions.Angiogenesis and neurogenesis (for example, the birth of new neural stem cells) are closely linked and influence one another — this review highlights the molecular signals that are involved.The organization of both the vascular and nervous systems requires mechanisms that determine boundary formation and the segregation of distinct cell populations: both the vascular and neural systems use common signals.Wiring of the nervous and vascular networks involves the sophisticated use of attractant and repellant signals. Remarkably, both systems often use common genetic pathways to achieve this goal.Vessels and nerves often track together — the recent genetic insights into how they do so are reviewed.There are many more neuro-vascular disorders than originally anticipated; a perspective on their genetic basis and possible treatment is discussed. More... »

PAGES

710-720

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nrg1158

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