Blood vessels and nerves: common signals, pathways and diseases View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2003-09

AUTHORS

Peter Carmeliet

ABSTRACT

Key PointsThis article presents an overview of the emerging evidence of how neurons and blood vessels share common genetic pathways to acquire their fate, grow, pattern and navigate, and how both the vascular and neural systems are linked.Both neural and vascular progenitors use common genetic pathways to differentiate into specialized cell subtypes, all of which are optimally equipped to perform specific functions.Angiogenesis and neurogenesis (for example, the birth of new neural stem cells) are closely linked and influence one another — this review highlights the molecular signals that are involved.The organization of both the vascular and nervous systems requires mechanisms that determine boundary formation and the segregation of distinct cell populations: both the vascular and neural systems use common signals.Wiring of the nervous and vascular networks involves the sophisticated use of attractant and repellant signals. Remarkably, both systems often use common genetic pathways to achieve this goal.Vessels and nerves often track together — the recent genetic insights into how they do so are reviewed.There are many more neuro-vascular disorders than originally anticipated; a perspective on their genetic basis and possible treatment is discussed. More... »

PAGES

710-720

References to SciGraph publications

  • 1999-10. Id1 and Id3 are required for neurogenesis, angiogenesis and vascularization of tumour xenografts in NATURE
  • 2002-09. Endocrine gland–derived VEGF and the emerging hypothesis of organ-specific regulation of angiogenesis in NATURE MEDICINE
  • 2003-06-01. Endothelial signaling during development in NATURE MEDICINE
  • 2003-06-01. Angiogenesis in health and disease in NATURE MEDICINE
  • 2001-07. Nicotine stimulates angiogenesis and promotes tumor growth and atherosclerosis in NATURE MEDICINE
  • 2001-11. The development of neural stem cells in NATURE
  • 2000-11. The role of Sonic hedgehog in neural tube patterning in CELLULAR AND MOLECULAR LIFE SCIENCES
  • 2002-09. Arteries and veins: making a difference with zebrafish in NATURE REVIEWS GENETICS
  • 2002. Neuropilins as Semaphorin Receptors in NEUROPILIN
  • 1999-07. Eph receptors and ephrins restrict cell intermingling and communication in NATURE
  • 2003-01-21. VEGF: A modifier of the del22q11 (DiGeorge) syndrome? in NATURE MEDICINE
  • 2000-11. Flk1-positive cells derived from embryonic stem cells serve as vascular progenitors in NATURE
  • 2003-07-06. VEGF is a modifier of amyotrophic lateral sclerosis in mice and humans and protects motoneurons against ischemic death in NATURE GENETICS
  • 1999-06. VEGF couples hypertrophic cartilage remodeling, ossification and angiogenesis during endochondral bone formation in NATURE MEDICINE
  • 1992-07. The origin and development of retinal astrocytes in the mouse in BRAIN CELL BIOLOGY
  • 2001-11. From charcot to lou gehrig: deciphering selective motor neuron death in als in NATURE REVIEWS NEUROSCIENCE
  • 2000-05. The VEGF Splice Variants: Properties, Receptors, and Usage for the Treatment of Ischemic Diseases in HERZ
  • 1999-10. Controlling the cellular brakes in NATURE
  • 2001-06. Deletion of the hypoxia-response element in the vascular endothelial growth factor promoter causes motor neuron degeneration in NATURE GENETICS
  • 2002-06. Induction of the neural crest: a multigene process in NATURE REVIEWS GENETICS
  • 2002-02-01. Specialization of tumour vasculature in NATURE REVIEWS CANCER
  • 2002-12-23. Control of hippocampal dendritic spine morphology through ephrin-A3/EphA4 signaling in NATURE NEUROSCIENCE
  • 2001-05-01. The neurotransmitter dopamine inhibits angiogenesis induced by vascular permeability factor/vascular endothelial growth factor in NATURE MEDICINE
  • 2002. Mechanisms Regulating Lineage Diversity During Mammalian Cerebral Cortical Neurogenesis and Gliogenesis in CORTICAL DEVELOPMENT
  • 2001-11. Gridlock signalling pathway fashions the first embryonic artery in NATURE
  • 1999-05-01. Impaired myocardial angiogenesis and ischemic cardiomyopathy in mice lacking the vascular endothelial growth factor isoforms VEGF164 and VEGF188 in NATURE MEDICINE
  • 2002. The Function of Neuropilin/Plexin Complexes in NEUROPILIN
  • 2003-06. Regulation of angiogenesis by hypoxia: role of the HIF system in NATURE MEDICINE
  • 2002-06-10. Loss of HIF-2α and inhibition of VEGF impair fetal lung maturation, whereas treatment with VEGF prevents fatal respiratory distress in premature mice in NATURE MEDICINE
  • 2000-11. One cell, two fates in NATURE
  • 2002-08-05. Irradiation induces neural precursor-cell dysfunction in NATURE MEDICINE
  • 2001-08. Creating unique blood vessels in NATURE
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nrg1158

    DOI

    http://dx.doi.org/10.1038/nrg1158

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1000928453

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/12951572


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Biological Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0604", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Genetics", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Animals", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Blood Vessels", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Body Patterning", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cell Differentiation", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Endothelial Growth Factors", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Endothelium, Vascular", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Intercellular Signaling Peptides and Proteins", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Lymphokines", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Neovascularization, Physiologic", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Nervous System", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Nervous System Diseases", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Nervous System Physiological Phenomena", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Signal Transduction", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Vascular Diseases", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Vascular Endothelial Growth Factor A", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Vascular Endothelial Growth Factors", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Center for Transgene Technology and Gene Therapy, Flanders Interuniversity Institute for Biotechnology, Katholieke Universiteit Leuven, Campus Gasthuisberg, Herestraat 49, B-3000, Leuven, Belgium", 
              "id": "http://www.grid.ac/institutes/grid.5596.f", 
              "name": [
                "Center for Transgene Technology and Gene Therapy, Flanders Interuniversity Institute for Biotechnology, Katholieke Universiteit Leuven, Campus Gasthuisberg, Herestraat 49, B-3000, Leuven, Belgium"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Carmeliet", 
            "givenName": "Peter", 
            "id": "sg:person.01033041553.19", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01033041553.19"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1038/nrg819", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041958218", 
              "https://doi.org/10.1038/nrg819"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/44304", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039564246", 
              "https://doi.org/10.1038/44304"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng1211", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024748064", 
              "https://doi.org/10.1038/ng1211"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/978-3-540-46006-0_2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019375520", 
              "https://doi.org/10.1007/978-3-540-46006-0_2"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf01186955", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019258487", 
              "https://doi.org/10.1007/bf01186955"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/21907", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024487580", 
              "https://doi.org/10.1038/21907"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/89961", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038844970", 
              "https://doi.org/10.1038/89961"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/35091178", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024949660", 
              "https://doi.org/10.1038/35091178"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm721", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001218981", 
              "https://doi.org/10.1038/nm721"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/35040568", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019378335", 
              "https://doi.org/10.1038/35040568"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/35102174", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029692486", 
              "https://doi.org/10.1038/35102174"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/978-1-4615-0119-0_2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043407738", 
              "https://doi.org/10.1007/978-1-4615-0119-0_2"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm819", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015788429", 
              "https://doi.org/10.1038/nm819"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/35040684", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007307220", 
              "https://doi.org/10.1038/35040684"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/35102599", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009535704", 
              "https://doi.org/10.1038/35102599"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/8379", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052764754", 
              "https://doi.org/10.1038/8379"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm0603-677", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020460331", 
              "https://doi.org/10.1038/nm0603-677"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/87895", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042088556", 
              "https://doi.org/10.1038/87895"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrc724", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022623295", 
              "https://doi.org/10.1038/nrc724"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm0603-653", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010143012", 
              "https://doi.org/10.1038/nm0603-653"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/978-1-4615-0119-0_6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041084353", 
              "https://doi.org/10.1007/978-1-4615-0119-0_6"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/9467", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024593021", 
              "https://doi.org/10.1038/9467"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm0902-913", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025067021", 
              "https://doi.org/10.1038/nm0902-913"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/88842", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012637074", 
              "https://doi.org/10.1038/88842"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/pl00000652", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007372844", 
              "https://doi.org/10.1007/pl00000652"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nn994", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037079838", 
              "https://doi.org/10.1038/nn994"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/35097565", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032464423", 
              "https://doi.org/10.1038/35097565"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/pl00001950", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000504442", 
              "https://doi.org/10.1007/pl00001950"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm749", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044855885", 
              "https://doi.org/10.1038/nm749"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm0603-661", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045430171", 
              "https://doi.org/10.1038/nm0603-661"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/44334", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001061614", 
              "https://doi.org/10.1038/44334"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrg888", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048334377", 
              "https://doi.org/10.1038/nrg888"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2003-09", 
        "datePublishedReg": "2003-09-01", 
        "description": "Key PointsThis article presents an overview of the emerging evidence of how neurons and blood vessels share common genetic pathways to acquire their fate, grow, pattern and navigate, and how both the vascular and neural systems are linked.Both neural and vascular progenitors use common genetic pathways to differentiate into specialized cell subtypes, all of which are optimally equipped to perform specific functions.Angiogenesis and neurogenesis (for example, the birth of new neural stem cells) are closely linked and influence one another \u2014 this review highlights the molecular signals that are involved.The organization of both the vascular and nervous systems requires mechanisms that determine boundary formation and the segregation of distinct cell populations: both the vascular and neural systems use common signals.Wiring of the nervous and vascular networks involves the sophisticated use of attractant and repellant signals. Remarkably, both systems often use common genetic pathways to achieve this goal.Vessels and nerves often track together \u2014 the recent genetic insights into how they do so are reviewed.There are many more neuro-vascular disorders than originally anticipated; a perspective on their genetic basis and possible treatment is discussed.", 
        "genre": "article", 
        "id": "sg:pub.10.1038/nrg1158", 
        "isAccessibleForFree": false, 
        "isPartOf": [
          {
            "id": "sg:journal.1023607", 
            "issn": [
              "1471-0056", 
              "1471-0064"
            ], 
            "name": "Nature Reviews Genetics", 
            "publisher": "Springer Nature", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "9", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "4"
          }
        ], 
        "keywords": [
          "common genetic pathway", 
          "genetic pathways", 
          "distinct cell populations", 
          "Key PointsThis article", 
          "genetic basis", 
          "genetic insights", 
          "vascular progenitors", 
          "molecular signals", 
          "common signal", 
          "specific functions", 
          "blood vessels", 
          "boundary formation", 
          "cell populations", 
          "pathway", 
          "recent genetic insights", 
          "cell subtypes", 
          "nervous system", 
          "possible treatment", 
          "neural systems", 
          "nerve", 
          "vascular network", 
          "progenitors", 
          "attractants", 
          "vessels", 
          "fate", 
          "neurogenesis", 
          "angiogenesis", 
          "signals", 
          "segregation", 
          "subtypes", 
          "disease", 
          "neurons", 
          "disorders", 
          "insights", 
          "mechanism", 
          "treatment", 
          "population", 
          "patterns", 
          "function", 
          "review", 
          "formation", 
          "evidence", 
          "basis", 
          "system", 
          "organization", 
          "use", 
          "wiring", 
          "overview", 
          "sophisticated use", 
          "goal", 
          "network", 
          "article", 
          "perspective", 
          "navigates"
        ], 
        "name": "Blood vessels and nerves: common signals, pathways and diseases", 
        "pagination": "710-720", 
        "productId": [
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1000928453"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1038/nrg1158"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "12951572"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1038/nrg1158", 
          "https://app.dimensions.ai/details/publication/pub.1000928453"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2022-10-01T06:32", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-springernature-scigraph/baseset/20221001/entities/gbq_results/article/article_373.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://doi.org/10.1038/nrg1158"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/nrg1158'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/nrg1158'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/nrg1158'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/nrg1158'


     

    This table displays all metadata directly associated to this object as RDF triples.

    311 TRIPLES      21 PREDICATES      128 URIs      88 LITERALS      24 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1038/nrg1158 schema:about N08b64524c4934898b0f69678b1dd3d6f
    2 N099dd31606a14b83ad55aa7f1d0bb1c0
    3 N31ccf42c00c04f33b6344e591d14350e
    4 N37a9f0010a90451d986720c503eba01e
    5 N39010e3826ea46d7b9d2782eb574af86
    6 N427d2cdbb37341dd8bd8840d6710079f
    7 N6c051df71144473fb369c4cb4ae47178
    8 N6c06a68783ee4490b0cccb627da82097
    9 N6c3da083745f4d4eb9a626b0ff387f1d
    10 N93c200e57b9246bcbe690816fcc6ec08
    11 Na25c6727b7984babadb851cf67be0973
    12 Na5c92b5707b34e428df69a267f3ec239
    13 Na967eb8524964638aaffb74f0a457475
    14 Nc8f5f960e4e944acbe5a8e7de3fdba35
    15 Nd005a656f8b441679fe7ef9cfec3da82
    16 Nd4ea00d384c941eba35f44678e6f7c56
    17 Ne9621574fc674b97a926d803e9c2c83e
    18 anzsrc-for:06
    19 anzsrc-for:0604
    20 schema:author N435bed8447144a0ab1e89a9366aacdfb
    21 schema:citation sg:pub.10.1007/978-1-4615-0119-0_2
    22 sg:pub.10.1007/978-1-4615-0119-0_6
    23 sg:pub.10.1007/978-3-540-46006-0_2
    24 sg:pub.10.1007/bf01186955
    25 sg:pub.10.1007/pl00000652
    26 sg:pub.10.1007/pl00001950
    27 sg:pub.10.1038/21907
    28 sg:pub.10.1038/35040568
    29 sg:pub.10.1038/35040684
    30 sg:pub.10.1038/35091178
    31 sg:pub.10.1038/35097565
    32 sg:pub.10.1038/35102174
    33 sg:pub.10.1038/35102599
    34 sg:pub.10.1038/44304
    35 sg:pub.10.1038/44334
    36 sg:pub.10.1038/8379
    37 sg:pub.10.1038/87895
    38 sg:pub.10.1038/88842
    39 sg:pub.10.1038/89961
    40 sg:pub.10.1038/9467
    41 sg:pub.10.1038/ng1211
    42 sg:pub.10.1038/nm0603-653
    43 sg:pub.10.1038/nm0603-661
    44 sg:pub.10.1038/nm0603-677
    45 sg:pub.10.1038/nm0902-913
    46 sg:pub.10.1038/nm721
    47 sg:pub.10.1038/nm749
    48 sg:pub.10.1038/nm819
    49 sg:pub.10.1038/nn994
    50 sg:pub.10.1038/nrc724
    51 sg:pub.10.1038/nrg819
    52 sg:pub.10.1038/nrg888
    53 schema:datePublished 2003-09
    54 schema:datePublishedReg 2003-09-01
    55 schema:description Key PointsThis article presents an overview of the emerging evidence of how neurons and blood vessels share common genetic pathways to acquire their fate, grow, pattern and navigate, and how both the vascular and neural systems are linked.Both neural and vascular progenitors use common genetic pathways to differentiate into specialized cell subtypes, all of which are optimally equipped to perform specific functions.Angiogenesis and neurogenesis (for example, the birth of new neural stem cells) are closely linked and influence one another — this review highlights the molecular signals that are involved.The organization of both the vascular and nervous systems requires mechanisms that determine boundary formation and the segregation of distinct cell populations: both the vascular and neural systems use common signals.Wiring of the nervous and vascular networks involves the sophisticated use of attractant and repellant signals. Remarkably, both systems often use common genetic pathways to achieve this goal.Vessels and nerves often track together — the recent genetic insights into how they do so are reviewed.There are many more neuro-vascular disorders than originally anticipated; a perspective on their genetic basis and possible treatment is discussed.
    56 schema:genre article
    57 schema:isAccessibleForFree false
    58 schema:isPartOf N7e0118a3497b48769bdef63afb199e22
    59 Nae6ba1cb486f4d298fbfbc24ba9ee33f
    60 sg:journal.1023607
    61 schema:keywords Key PointsThis article
    62 angiogenesis
    63 article
    64 attractants
    65 basis
    66 blood vessels
    67 boundary formation
    68 cell populations
    69 cell subtypes
    70 common genetic pathway
    71 common signal
    72 disease
    73 disorders
    74 distinct cell populations
    75 evidence
    76 fate
    77 formation
    78 function
    79 genetic basis
    80 genetic insights
    81 genetic pathways
    82 goal
    83 insights
    84 mechanism
    85 molecular signals
    86 navigates
    87 nerve
    88 nervous system
    89 network
    90 neural systems
    91 neurogenesis
    92 neurons
    93 organization
    94 overview
    95 pathway
    96 patterns
    97 perspective
    98 population
    99 possible treatment
    100 progenitors
    101 recent genetic insights
    102 review
    103 segregation
    104 signals
    105 sophisticated use
    106 specific functions
    107 subtypes
    108 system
    109 treatment
    110 use
    111 vascular network
    112 vascular progenitors
    113 vessels
    114 wiring
    115 schema:name Blood vessels and nerves: common signals, pathways and diseases
    116 schema:pagination 710-720
    117 schema:productId N000d03366c7946948f828b7c1bedd788
    118 N2577fd2178854e7eaf7197d869702db4
    119 N8a8b1d3968134d338fad3e9540dbd5a5
    120 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000928453
    121 https://doi.org/10.1038/nrg1158
    122 schema:sdDatePublished 2022-10-01T06:32
    123 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    124 schema:sdPublisher N20efad3942f346b8a46f6d5354941535
    125 schema:url https://doi.org/10.1038/nrg1158
    126 sgo:license sg:explorer/license/
    127 sgo:sdDataset articles
    128 rdf:type schema:ScholarlyArticle
    129 N000d03366c7946948f828b7c1bedd788 schema:name pubmed_id
    130 schema:value 12951572
    131 rdf:type schema:PropertyValue
    132 N08b64524c4934898b0f69678b1dd3d6f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    133 schema:name Vascular Diseases
    134 rdf:type schema:DefinedTerm
    135 N099dd31606a14b83ad55aa7f1d0bb1c0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    136 schema:name Signal Transduction
    137 rdf:type schema:DefinedTerm
    138 N20efad3942f346b8a46f6d5354941535 schema:name Springer Nature - SN SciGraph project
    139 rdf:type schema:Organization
    140 N2577fd2178854e7eaf7197d869702db4 schema:name dimensions_id
    141 schema:value pub.1000928453
    142 rdf:type schema:PropertyValue
    143 N31ccf42c00c04f33b6344e591d14350e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    144 schema:name Endothelial Growth Factors
    145 rdf:type schema:DefinedTerm
    146 N37a9f0010a90451d986720c503eba01e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    147 schema:name Vascular Endothelial Growth Factor A
    148 rdf:type schema:DefinedTerm
    149 N39010e3826ea46d7b9d2782eb574af86 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    150 schema:name Endothelium, Vascular
    151 rdf:type schema:DefinedTerm
    152 N427d2cdbb37341dd8bd8840d6710079f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    153 schema:name Intercellular Signaling Peptides and Proteins
    154 rdf:type schema:DefinedTerm
    155 N435bed8447144a0ab1e89a9366aacdfb rdf:first sg:person.01033041553.19
    156 rdf:rest rdf:nil
    157 N6c051df71144473fb369c4cb4ae47178 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    158 schema:name Blood Vessels
    159 rdf:type schema:DefinedTerm
    160 N6c06a68783ee4490b0cccb627da82097 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    161 schema:name Nervous System
    162 rdf:type schema:DefinedTerm
    163 N6c3da083745f4d4eb9a626b0ff387f1d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    164 schema:name Vascular Endothelial Growth Factors
    165 rdf:type schema:DefinedTerm
    166 N7e0118a3497b48769bdef63afb199e22 schema:volumeNumber 4
    167 rdf:type schema:PublicationVolume
    168 N8a8b1d3968134d338fad3e9540dbd5a5 schema:name doi
    169 schema:value 10.1038/nrg1158
    170 rdf:type schema:PropertyValue
    171 N93c200e57b9246bcbe690816fcc6ec08 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    172 schema:name Animals
    173 rdf:type schema:DefinedTerm
    174 Na25c6727b7984babadb851cf67be0973 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    175 schema:name Lymphokines
    176 rdf:type schema:DefinedTerm
    177 Na5c92b5707b34e428df69a267f3ec239 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    178 schema:name Humans
    179 rdf:type schema:DefinedTerm
    180 Na967eb8524964638aaffb74f0a457475 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    181 schema:name Nervous System Physiological Phenomena
    182 rdf:type schema:DefinedTerm
    183 Nae6ba1cb486f4d298fbfbc24ba9ee33f schema:issueNumber 9
    184 rdf:type schema:PublicationIssue
    185 Nc8f5f960e4e944acbe5a8e7de3fdba35 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    186 schema:name Neovascularization, Physiologic
    187 rdf:type schema:DefinedTerm
    188 Nd005a656f8b441679fe7ef9cfec3da82 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    189 schema:name Body Patterning
    190 rdf:type schema:DefinedTerm
    191 Nd4ea00d384c941eba35f44678e6f7c56 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    192 schema:name Cell Differentiation
    193 rdf:type schema:DefinedTerm
    194 Ne9621574fc674b97a926d803e9c2c83e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    195 schema:name Nervous System Diseases
    196 rdf:type schema:DefinedTerm
    197 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
    198 schema:name Biological Sciences
    199 rdf:type schema:DefinedTerm
    200 anzsrc-for:0604 schema:inDefinedTermSet anzsrc-for:
    201 schema:name Genetics
    202 rdf:type schema:DefinedTerm
    203 sg:journal.1023607 schema:issn 1471-0056
    204 1471-0064
    205 schema:name Nature Reviews Genetics
    206 schema:publisher Springer Nature
    207 rdf:type schema:Periodical
    208 sg:person.01033041553.19 schema:affiliation grid-institutes:grid.5596.f
    209 schema:familyName Carmeliet
    210 schema:givenName Peter
    211 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01033041553.19
    212 rdf:type schema:Person
    213 sg:pub.10.1007/978-1-4615-0119-0_2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043407738
    214 https://doi.org/10.1007/978-1-4615-0119-0_2
    215 rdf:type schema:CreativeWork
    216 sg:pub.10.1007/978-1-4615-0119-0_6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041084353
    217 https://doi.org/10.1007/978-1-4615-0119-0_6
    218 rdf:type schema:CreativeWork
    219 sg:pub.10.1007/978-3-540-46006-0_2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019375520
    220 https://doi.org/10.1007/978-3-540-46006-0_2
    221 rdf:type schema:CreativeWork
    222 sg:pub.10.1007/bf01186955 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019258487
    223 https://doi.org/10.1007/bf01186955
    224 rdf:type schema:CreativeWork
    225 sg:pub.10.1007/pl00000652 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007372844
    226 https://doi.org/10.1007/pl00000652
    227 rdf:type schema:CreativeWork
    228 sg:pub.10.1007/pl00001950 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000504442
    229 https://doi.org/10.1007/pl00001950
    230 rdf:type schema:CreativeWork
    231 sg:pub.10.1038/21907 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024487580
    232 https://doi.org/10.1038/21907
    233 rdf:type schema:CreativeWork
    234 sg:pub.10.1038/35040568 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019378335
    235 https://doi.org/10.1038/35040568
    236 rdf:type schema:CreativeWork
    237 sg:pub.10.1038/35040684 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007307220
    238 https://doi.org/10.1038/35040684
    239 rdf:type schema:CreativeWork
    240 sg:pub.10.1038/35091178 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024949660
    241 https://doi.org/10.1038/35091178
    242 rdf:type schema:CreativeWork
    243 sg:pub.10.1038/35097565 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032464423
    244 https://doi.org/10.1038/35097565
    245 rdf:type schema:CreativeWork
    246 sg:pub.10.1038/35102174 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029692486
    247 https://doi.org/10.1038/35102174
    248 rdf:type schema:CreativeWork
    249 sg:pub.10.1038/35102599 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009535704
    250 https://doi.org/10.1038/35102599
    251 rdf:type schema:CreativeWork
    252 sg:pub.10.1038/44304 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039564246
    253 https://doi.org/10.1038/44304
    254 rdf:type schema:CreativeWork
    255 sg:pub.10.1038/44334 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001061614
    256 https://doi.org/10.1038/44334
    257 rdf:type schema:CreativeWork
    258 sg:pub.10.1038/8379 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052764754
    259 https://doi.org/10.1038/8379
    260 rdf:type schema:CreativeWork
    261 sg:pub.10.1038/87895 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042088556
    262 https://doi.org/10.1038/87895
    263 rdf:type schema:CreativeWork
    264 sg:pub.10.1038/88842 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012637074
    265 https://doi.org/10.1038/88842
    266 rdf:type schema:CreativeWork
    267 sg:pub.10.1038/89961 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038844970
    268 https://doi.org/10.1038/89961
    269 rdf:type schema:CreativeWork
    270 sg:pub.10.1038/9467 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024593021
    271 https://doi.org/10.1038/9467
    272 rdf:type schema:CreativeWork
    273 sg:pub.10.1038/ng1211 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024748064
    274 https://doi.org/10.1038/ng1211
    275 rdf:type schema:CreativeWork
    276 sg:pub.10.1038/nm0603-653 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010143012
    277 https://doi.org/10.1038/nm0603-653
    278 rdf:type schema:CreativeWork
    279 sg:pub.10.1038/nm0603-661 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045430171
    280 https://doi.org/10.1038/nm0603-661
    281 rdf:type schema:CreativeWork
    282 sg:pub.10.1038/nm0603-677 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020460331
    283 https://doi.org/10.1038/nm0603-677
    284 rdf:type schema:CreativeWork
    285 sg:pub.10.1038/nm0902-913 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025067021
    286 https://doi.org/10.1038/nm0902-913
    287 rdf:type schema:CreativeWork
    288 sg:pub.10.1038/nm721 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001218981
    289 https://doi.org/10.1038/nm721
    290 rdf:type schema:CreativeWork
    291 sg:pub.10.1038/nm749 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044855885
    292 https://doi.org/10.1038/nm749
    293 rdf:type schema:CreativeWork
    294 sg:pub.10.1038/nm819 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015788429
    295 https://doi.org/10.1038/nm819
    296 rdf:type schema:CreativeWork
    297 sg:pub.10.1038/nn994 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037079838
    298 https://doi.org/10.1038/nn994
    299 rdf:type schema:CreativeWork
    300 sg:pub.10.1038/nrc724 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022623295
    301 https://doi.org/10.1038/nrc724
    302 rdf:type schema:CreativeWork
    303 sg:pub.10.1038/nrg819 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041958218
    304 https://doi.org/10.1038/nrg819
    305 rdf:type schema:CreativeWork
    306 sg:pub.10.1038/nrg888 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048334377
    307 https://doi.org/10.1038/nrg888
    308 rdf:type schema:CreativeWork
    309 grid-institutes:grid.5596.f schema:alternateName Center for Transgene Technology and Gene Therapy, Flanders Interuniversity Institute for Biotechnology, Katholieke Universiteit Leuven, Campus Gasthuisberg, Herestraat 49, B-3000, Leuven, Belgium
    310 schema:name Center for Transgene Technology and Gene Therapy, Flanders Interuniversity Institute for Biotechnology, Katholieke Universiteit Leuven, Campus Gasthuisberg, Herestraat 49, B-3000, Leuven, Belgium
    311 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...