Towards a genomics-informed, real-time, global pathogen surveillance system View Full Text


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Article Info

DATE

2017-11-13

AUTHORS

Jennifer L. Gardy, Nicholas J. Loman

ABSTRACT

Key PointsDespite the recommendations of many expert groups, public health surveillance systems have not yet improved to the point where emerging infectious threats can be better anticipated. The Ebola and Zika epidemics are the latest to demonstrate that pathogens often spread undetected for some time before being diagnosed in a population.Next-generation sequencing, particularly the use of portable genomic sequencers, offers an intriguing solution to the diagnosis and surveillance problems — it enables rapid in situ diagnostics through amplicon-based or metagenomics approaches and creates a stream of genomic data that can reveal critical epidemiological aspects of an outbreak or epidemic's dynamics.Genomic epidemiology for rapid outbreak response has demonstrated some early successes in Ebola and Zika, but there are a number of challenges to overcome — some technical and some cultural. Data sharing is one of these, but other ethical and legal issues must be considered.The power of a genomic epidemiology approach could be extended by incorporating concepts from digital disease detection and One Health. By coupling sequencing to an enhanced surveillance and response platform, we could take a more anticipatory approach to outbreak prevention and control. More... »

PAGES

9-20

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    52 schema:description Key PointsDespite the recommendations of many expert groups, public health surveillance systems have not yet improved to the point where emerging infectious threats can be better anticipated. The Ebola and Zika epidemics are the latest to demonstrate that pathogens often spread undetected for some time before being diagnosed in a population.Next-generation sequencing, particularly the use of portable genomic sequencers, offers an intriguing solution to the diagnosis and surveillance problems — it enables rapid in situ diagnostics through amplicon-based or metagenomics approaches and creates a stream of genomic data that can reveal critical epidemiological aspects of an outbreak or epidemic's dynamics.Genomic epidemiology for rapid outbreak response has demonstrated some early successes in Ebola and Zika, but there are a number of challenges to overcome — some technical and some cultural. Data sharing is one of these, but other ethical and legal issues must be considered.The power of a genomic epidemiology approach could be extended by incorporating concepts from digital disease detection and One Health. By coupling sequencing to an enhanced surveillance and response platform, we could take a more anticipatory approach to outbreak prevention and control.
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