Human genetic variation and the gut microbiome in disease View Full Text


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Article Info

DATE

2017-08-21

AUTHORS

Andrew Brantley Hall, Andrew C. Tolonen, Ramnik J. Xavier

ABSTRACT

Key PointsHost genetics shape the composition of the gut microbiome in concert with environmental factors such as diet and lifestyle.Certain host genetic variants predispose an individual towards microbiome dysbiosis, which is an important factor in diseases of metabolism and immunity.A subset of species in the gut microbiome are heritable, especially representatives from the phyla Firmicutes and Verrucomicrobia.Variants in single genes (for example, LCT, NOD2 and FUT2) affect the composition of the gut microbiome.Microbiome genome-wide association studies hold promise for the identification of additional host genetic variants that affect disease progression by perturbing the composition of the microbiome. More... »

PAGES

690-699

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