Microbial genome-wide association studies: lessons from human GWAS View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2017-01

AUTHORS

Robert A. Power, Julian Parkhill, Tulio de Oliveira

ABSTRACT

The reduced costs of sequencing have led to whole-genome sequences for a large number of microorganisms, enabling the application of microbial genome-wide association studies (GWAS). Given the successes of human GWAS in understanding disease aetiology and identifying potential drug targets, microbial GWAS are likely to further advance our understanding of infectious diseases. These advances include insights into pressing global health problems, such as antibiotic resistance and disease transmission. In this Review, we outline the methodologies of GWAS, the current state of the field of microbial GWAS, and how lessons from human GWAS can direct the future of the field. More... »

PAGES

41-50

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    http://scigraph.springernature.com/pub.10.1038/nrg.2016.132

    DOI

    http://dx.doi.org/10.1038/nrg.2016.132

    DIMENSIONS

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    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/27840430


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