Molecular insights into the aetiology of female reproductive ageing View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2015-12

AUTHORS

John R. B. Perry, Anna Murray, Felix R. Day, Ken K. Ong

ABSTRACT

As age at pubertal onset declines and age at first pregnancy increases, the mechanisms that regulate female reproductive lifespan become increasingly relevant to population health. The timing of menarche and menopause can have profound effects not only on fertility but also on the risk of diseases such as type 2 diabetes mellitus, cardiovascular disease and breast cancer. Genetic studies have identified dozens of highly penetrant rare mutations associated with reproductive disorders, and also ∼175 common genetic variants associated with the timing of puberty or menopause. These findings, alongside other functional studies, have highlighted a diverse range of mechanisms involved in reproductive ageing, implicating core biological processes such as cell cycle regulation and energy homeostasis. The aim of this article is to review the contribution of such genetic findings to our understanding of the molecular regulation of reproductive timing, as well as the biological basis of the epidemiological links between reproductive ageing and disease risk. More... »

PAGES

725-734

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nrendo.2015.167

    DOI

    http://dx.doi.org/10.1038/nrendo.2015.167

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1007045425

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/26460341


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