Novel metabolic biomarkers of cardiovascular disease View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2014-11

AUTHORS

Majken K. Jensen, Monica L. Bertoia, Leah E. Cahill, Isha Agarwal, Eric B. Rimm, Kenneth J. Mukamal

ABSTRACT

Coronary heart disease (CHD) accounts for one in every six deaths in US individuals. Great advances have been made in identifying important risk factors for CHD, such as hypertension, diabetes mellitus, smoking and hypercholesterolaemia, which have led to major developments in therapy. In particular, statins represent one of the greatest successes in the prevention of CHD. While these standard risk factors are important, an obvious opportunity exists to take advantage of ongoing scientific research to better risk-stratify individuals and to identify new treatment targets. In this Review, we summarize ongoing scientific research in a number of metabolic molecules or features, including lipoproteins, homocysteine, calcium metabolism and glycaemic markers. We evaluate the current state of the research and the strength of evidence supporting each emerging biomarker. We also discuss whether the associations with CHD are strong and consistent enough to improve current risk stratification metrics, and whether these markers enhance our understanding of the underlying biology of CHD and thus point towards new treatment options. More... »

PAGES

659-672

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nrendo.2014.155

DOI

http://dx.doi.org/10.1038/nrendo.2014.155

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1010485071

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/25178732


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