Snakebite envenoming View Full Text


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Article Info

DATE

2017-09-14

AUTHORS

José María Gutiérrez, Juan J. Calvete, Abdulrazaq G. Habib, Robert A. Harrison, David J. Williams, David A. Warrell

ABSTRACT

Snakebite envenoming is a neglected tropical disease that kills >100,000 people and maims >400,000 people every year. Impoverished populations living in the rural tropics are particularly vulnerable; snakebite envenoming perpetuates the cycle of poverty. Snake venoms are complex mixtures of proteins that exert a wide range of toxic actions. The high variability in snake venom composition is responsible for the various clinical manifestations in envenomings, ranging from local tissue damage to potentially life-threatening systemic effects. Intravenous administration of antivenom is the only specific treatment to counteract envenoming. Analgesics, ventilator support, fluid therapy, haemodialysis and antibiotic therapy are also used. Novel therapeutic alternatives based on recombinant antibody technologies and new toxin inhibitors are being explored. Confronting snakebite envenoming at a global level demands the implementation of an integrated intervention strategy involving the WHO, the research community, antivenom manufacturers, regulatory agencies, national and regional health authorities, professional health organizations, international funding agencies, advocacy groups and civil society institutions. More... »

PAGES

nrdp201763

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nrdp.2017.63

    DOI

    http://dx.doi.org/10.1038/nrdp.2017.63

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1091688590

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/28905944


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