Obstructive sleep apnoea syndrome View Full Text


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Article Info

DATE

2015-06-25

AUTHORS

Patrick Lévy, Malcolm Kohler, Walter T. McNicholas, Ferran Barbé, R. Doug McEvoy, Virend K. Somers, Lena Lavie, Jean-Louis Pépin

ABSTRACT

Obstructive sleep apnoea syndrome (OSAS) is a common clinical condition in which the throat narrows or collapses repeatedly during sleep, causing obstructive sleep apnoea events. The syndrome is particularly prevalent in middle-aged and older adults. The mechanism by which the upper airway collapses is not fully understood but is multifactorial and includes obesity, craniofacial changes, alteration in upper airway muscle function, pharyngeal neuropathy and fluid shift towards the neck. The direct consequences of the collapse are intermittent hypoxia and hypercapnia, recurrent arousals and increase in respiratory efforts, leading to secondary sympathetic activation, oxidative stress and systemic inflammation. Excessive daytime sleepiness is a burden for the majority of patients. OSAS is also associated with cardiovascular co-morbidities, including hypertension, arrhythmias, stroke, coronary heart disease, atherosclerosis and overall increased cardiovascular mortality, as well as metabolic dysfunction. Whether treating sleep apnoea can fully reverse its chronic consequences remains to be established in adequately designed studies. Continuous positive airway pressure (CPAP) is the primary treatment modality in patients with severe OSAS, whereas oral appliances are also widely used in mild to moderate forms. Finally, combining different treatment modalities such as CPAP and weight control is beneficial, but need to be evaluated in randomized controlled trials. For an illustrated summary of this Primer, visit: http://go.nature.com/Lwc6te More... »

PAGES

15015

References to SciGraph publications

  • 2006-02-21. Activation of nuclear factor κB in obstructive sleep apnea: a pathway leading to systemic inflammation in SLEEP AND BREATHING
  • 2006-05-02. The effect of sibutramine-assisted weight loss in men with obstructive sleep apnoea in INTERNATIONAL JOURNAL OF OBESITY
  • 2012-10-22. Bax/Mcl-1 balance affects neutrophil survival in intermittent hypoxia and obstructive sleep apnea: effects of p38MAPK and ERK1/2 signaling in JOURNAL OF TRANSLATIONAL MEDICINE
  • 2009-07-15. Effects of allopurinol on cardiac function and oxidant stress in chronic intermittent hypoxia in SLEEP AND BREATHING
  • 2012-09-26. Participation of protein kinase C in the activation of Nrf2 signaling by ischemic preconditioning in the isolated rabbit heart in MOLECULAR AND CELLULAR BIOCHEMISTRY
  • 2010-06-20. Obstructive sleep apnea causes oxidative damage to plasma lipids and proteins and decreases adiponectin levels in SLEEP AND BREATHING
  • 2003-09. Plasma levels of nitric oxide and L-arginine in sleep apnea patients in JOURNAL OF MOLECULAR NEUROSCIENCE
  • 2014-02-09. Severity of obstructive sleep apnea is associated with elevated plasma fibrinogen in otherwise healthy patients in SLEEP AND BREATHING
  • 2013-01-30. The impact of diet and lifestyle management strategies for obstructive sleep apnoea in adults: a systematic review and meta-analysis of randomised controlled trials in SLEEP AND BREATHING
  • 2012-12-14. Intermittent Hypoxia-Induced NF-κB and HO-1 Regulation in Human Endothelial EA.hy926 Cells in CELL BIOCHEMISTRY AND BIOPHYSICS
  • 2010-02-09. A systematic review of screening questionnaires for obstructive sleep apnea in JOURNAL CANADIEN D'ANESTHÉSIE
  • 1992-06. Parasympathetic hyperresponsiveness and bradyarrhythmias during apnoea in hypertension in CLINICAL AUTONOMIC RESEARCH
  • 2012-09-25. Mechanisms of cardiac dysfunction in obstructive sleep apnea in NATURE REVIEWS CARDIOLOGY
  • 1999-10. Measuring Quality of Live in Disorders of Sleep and Breathing in SLEEP AND BREATHING
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nrdp.2015.15

    DOI

    http://dx.doi.org/10.1038/nrdp.2015.15

    DIMENSIONS

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    https://www.ncbi.nlm.nih.gov/pubmed/27188535


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    31 schema:description Obstructive sleep apnoea syndrome (OSAS) is a common clinical condition in which the throat narrows or collapses repeatedly during sleep, causing obstructive sleep apnoea events. The syndrome is particularly prevalent in middle-aged and older adults. The mechanism by which the upper airway collapses is not fully understood but is multifactorial and includes obesity, craniofacial changes, alteration in upper airway muscle function, pharyngeal neuropathy and fluid shift towards the neck. The direct consequences of the collapse are intermittent hypoxia and hypercapnia, recurrent arousals and increase in respiratory efforts, leading to secondary sympathetic activation, oxidative stress and systemic inflammation. Excessive daytime sleepiness is a burden for the majority of patients. OSAS is also associated with cardiovascular co-morbidities, including hypertension, arrhythmias, stroke, coronary heart disease, atherosclerosis and overall increased cardiovascular mortality, as well as metabolic dysfunction. Whether treating sleep apnoea can fully reverse its chronic consequences remains to be established in adequately designed studies. Continuous positive airway pressure (CPAP) is the primary treatment modality in patients with severe OSAS, whereas oral appliances are also widely used in mild to moderate forms. Finally, combining different treatment modalities such as CPAP and weight control is beneficial, but need to be evaluated in randomized controlled trials. For an illustrated summary of this Primer, visit: http://go.nature.com/Lwc6te
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