Hepatitis C virus replicons: potential role for drug development View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2002-11

AUTHORS

Ralf Bartenschlager

ABSTRACT

The development of causal therapies depends on the availability of systems to determine the inhibitory capacity of a compound. As viruses are obligate intracellular parasites, the efficacy of an antiviral drug is usually evaluated in a cell-culture system. Unfortunately, the hepatitis C virus, the principal causative agent of acute and chronic liver disease, cannot be propagated efficiently in the laboratory. However, the recent development of a replicon system opens up an encouraging possibility for drug discovery. More... »

PAGES

911-916

References to SciGraph publications

Journal

TITLE

Nature Reviews Drug Discovery

ISSUE

11

VOLUME

1

Author Affiliations

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nrd942

DOI

http://dx.doi.org/10.1038/nrd942

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1002983118

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/12415250


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