Ontology type: schema:ScholarlyArticle
2002-11
AUTHORS ABSTRACTThe development of causal therapies depends on the availability of systems to determine the inhibitory capacity of a compound. As viruses are obligate intracellular parasites, the efficacy of an antiviral drug is usually evaluated in a cell-culture system. Unfortunately, the hepatitis C virus, the principal causative agent of acute and chronic liver disease, cannot be propagated efficiently in the laboratory. However, the recent development of a replicon system opens up an encouraging possibility for drug discovery. More... »
PAGES911-916
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DOIhttp://dx.doi.org/10.1038/nrd942
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