Protein tyrosine phosphatase 1B inhibitors for diabetes View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2002-09

AUTHORS

Theodore O. Johnson, Jacques Ermolieff, Michael R. Jirousek

ABSTRACT

Increased incidence of type 2 diabetes mellitus and obesity has elevated the medical need for new agents to treat these disease states. Resistance to the hormones insulin and leptin are hallmarks of both type 2 diabetes and obesity. Drugs that can ameliorate this resistance should be effective in treating type 2 diabetes and possibly obesity. Protein tyrosine phosphatase 1B (PTP1B) is thought to function as a negative regulator of insulin and leptin signal transduction. This article reviews PTP1B as a novel target for type 2 diabetes, and looks at the challenges in developing small-molecule inhibitors of this phosphatase. More... »

PAGES

696-709

Journal

TITLE

Nature Reviews Drug Discovery

ISSUE

9

VOLUME

1

Author Affiliations

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nrd895

    DOI

    http://dx.doi.org/10.1038/nrd895

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1011069918

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/12209150


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