The druggable genome View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2002-09

AUTHORS

Andrew L. Hopkins, Colin R. Groom

ABSTRACT

An assessment of the number of molecular targets that represent an opportunity for therapeutic intervention is crucial to the development of post-genomic research strategies within the pharmaceutical industry. Now that we know the size of the human genome, it is interesting to consider just how many molecular targets this opportunity represents. We start from the position that we understand the properties that are required for a good drug, and therefore must be able to understand what makes a good drug target. More... »

PAGES

727-730

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nrd892

DOI

http://dx.doi.org/10.1038/nrd892

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1046818756

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/12209152


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0604", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Genetics", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Biological Availability", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Chemistry, Pharmaceutical", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genome, Human", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Molecular Biology", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Pharmacokinetics", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Pfizer (United Kingdom)", 
          "id": "https://www.grid.ac/institutes/grid.418566.8", 
          "name": [
            "Andrew L. Hopkins and Colin R. Groom are at the Molecular Informatics, Structure and Design Department, Pfizer Global Research & Development, Sandwich, Kent, CT13 9NJ, UK."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hopkins", 
        "givenName": "Andrew L.", 
        "id": "sg:person.01025173055.90", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01025173055.90"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Pfizer (United Kingdom)", 
          "id": "https://www.grid.ac/institutes/grid.418566.8", 
          "name": [
            "Andrew L. Hopkins and Colin R. Groom are at the Molecular Informatics, Structure and Design Department, Pfizer Global Research & Development, Sandwich, Kent, CT13 9NJ, UK."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Groom", 
        "givenName": "Colin R.", 
        "id": "sg:person.01163554374.06", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01163554374.06"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1126/science.1058040", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001517867"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/83496", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011462196", 
          "https://doi.org/10.1038/83496"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/83496", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011462196", 
          "https://doi.org/10.1038/83496"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/85627", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016520094", 
          "https://doi.org/10.1038/85627"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/85627", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016520094", 
          "https://doi.org/10.1038/85627"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nbt1297-1318", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021256132", 
          "https://doi.org/10.1038/nbt1297-1318"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0169-409x(96)00423-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026263620"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/29.1.37", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029793403"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0958-1669(01)00271-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030159038"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/35057062", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042854081", 
          "https://doi.org/10.1038/35057062"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/35057062", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042854081", 
          "https://doi.org/10.1038/35057062"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/81137", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045090002", 
          "https://doi.org/10.1038/81137"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/81137", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045090002", 
          "https://doi.org/10.1038/81137"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nbt1196-1516", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052037467", 
          "https://doi.org/10.1038/nbt1196-1516"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1058969", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062444472"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.287.5460.1960", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062568772"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.287.5461.2204", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062568860"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083320189", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2002-09", 
    "datePublishedReg": "2002-09-01", 
    "description": "An assessment of the number of molecular targets that represent an opportunity for therapeutic intervention is crucial to the development of post-genomic research strategies within the pharmaceutical industry. Now that we know the size of the human genome, it is interesting to consider just how many molecular targets this opportunity represents. We start from the position that we understand the properties that are required for a good drug, and therefore must be able to understand what makes a good drug target.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/nrd892", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1327423", 
        "issn": [
          "1474-1776", 
          "1474-1784"
        ], 
        "name": "Nature Reviews Drug Discovery", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "9", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "1"
      }
    ], 
    "name": "The druggable genome", 
    "pagination": "727-730", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "df06c4f4b27dfa9023c33b72605634cc25c6225f5e191b409905fb9c047389d7"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "12209152"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101124171"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/nrd892"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1046818756"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/nrd892", 
      "https://app.dimensions.ai/details/publication/pub.1046818756"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T11:50", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000359_0000000359/records_29181_00000002.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://www.nature.com/articles/nrd892"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/nrd892'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/nrd892'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/nrd892'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/nrd892'


 

This table displays all metadata directly associated to this object as RDF triples.

147 TRIPLES      21 PREDICATES      49 URIs      27 LITERALS      15 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/nrd892 schema:about N329262f0820c40eb9d7e20f3322bc454
2 N455ebbc290e04842a16b613ff589b2ae
3 N85cbab27c3c94c1597b7cf5938778e79
4 N885f3ea3c03d4b889edf126e4f934cba
5 Ne6a4e96d3a0c4018acb1800962090b6b
6 Nf69cc0f06f8a440e9b7aef2adabd9639
7 anzsrc-for:06
8 anzsrc-for:0604
9 schema:author Nb27b6f07c7b043acb15a08b878160080
10 schema:citation sg:pub.10.1038/35057062
11 sg:pub.10.1038/81137
12 sg:pub.10.1038/83496
13 sg:pub.10.1038/85627
14 sg:pub.10.1038/nbt1196-1516
15 sg:pub.10.1038/nbt1297-1318
16 https://app.dimensions.ai/details/publication/pub.1083320189
17 https://doi.org/10.1016/s0169-409x(96)00423-1
18 https://doi.org/10.1016/s0958-1669(01)00271-3
19 https://doi.org/10.1093/nar/29.1.37
20 https://doi.org/10.1126/science.1058040
21 https://doi.org/10.1126/science.1058969
22 https://doi.org/10.1126/science.287.5460.1960
23 https://doi.org/10.1126/science.287.5461.2204
24 schema:datePublished 2002-09
25 schema:datePublishedReg 2002-09-01
26 schema:description An assessment of the number of molecular targets that represent an opportunity for therapeutic intervention is crucial to the development of post-genomic research strategies within the pharmaceutical industry. Now that we know the size of the human genome, it is interesting to consider just how many molecular targets this opportunity represents. We start from the position that we understand the properties that are required for a good drug, and therefore must be able to understand what makes a good drug target.
27 schema:genre research_article
28 schema:inLanguage en
29 schema:isAccessibleForFree false
30 schema:isPartOf N0313811943ad45389f9c2ddf62e33ecb
31 N1c04a6bf8672408d8a8c487255ac585b
32 sg:journal.1327423
33 schema:name The druggable genome
34 schema:pagination 727-730
35 schema:productId N0173ebb48c7a43a48aedb5b7ee187085
36 N5d1b05b91cda4195bbc9e8dd51c5e474
37 N755a566a0df54f8388c1f59ac0135351
38 N8a4864d4f7794971b0bff0d4434098d4
39 Nc7924cb93a2d42df9c19b706a4d0acea
40 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046818756
41 https://doi.org/10.1038/nrd892
42 schema:sdDatePublished 2019-04-11T11:50
43 schema:sdLicense https://scigraph.springernature.com/explorer/license/
44 schema:sdPublisher N94c122e253c74cda9773ab1ddb3d1d73
45 schema:url http://www.nature.com/articles/nrd892
46 sgo:license sg:explorer/license/
47 sgo:sdDataset articles
48 rdf:type schema:ScholarlyArticle
49 N0173ebb48c7a43a48aedb5b7ee187085 schema:name pubmed_id
50 schema:value 12209152
51 rdf:type schema:PropertyValue
52 N0313811943ad45389f9c2ddf62e33ecb schema:volumeNumber 1
53 rdf:type schema:PublicationVolume
54 N1c04a6bf8672408d8a8c487255ac585b schema:issueNumber 9
55 rdf:type schema:PublicationIssue
56 N329262f0820c40eb9d7e20f3322bc454 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
57 schema:name Molecular Biology
58 rdf:type schema:DefinedTerm
59 N455ebbc290e04842a16b613ff589b2ae schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
60 schema:name Biological Availability
61 rdf:type schema:DefinedTerm
62 N5d1b05b91cda4195bbc9e8dd51c5e474 schema:name doi
63 schema:value 10.1038/nrd892
64 rdf:type schema:PropertyValue
65 N755a566a0df54f8388c1f59ac0135351 schema:name dimensions_id
66 schema:value pub.1046818756
67 rdf:type schema:PropertyValue
68 N85cbab27c3c94c1597b7cf5938778e79 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
69 schema:name Humans
70 rdf:type schema:DefinedTerm
71 N885f3ea3c03d4b889edf126e4f934cba schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
72 schema:name Genome, Human
73 rdf:type schema:DefinedTerm
74 N8a4864d4f7794971b0bff0d4434098d4 schema:name readcube_id
75 schema:value df06c4f4b27dfa9023c33b72605634cc25c6225f5e191b409905fb9c047389d7
76 rdf:type schema:PropertyValue
77 N94c122e253c74cda9773ab1ddb3d1d73 schema:name Springer Nature - SN SciGraph project
78 rdf:type schema:Organization
79 Nb27b6f07c7b043acb15a08b878160080 rdf:first sg:person.01025173055.90
80 rdf:rest Ncf116b0eaac54bbb8d2b8c5d98feda60
81 Nc7924cb93a2d42df9c19b706a4d0acea schema:name nlm_unique_id
82 schema:value 101124171
83 rdf:type schema:PropertyValue
84 Ncf116b0eaac54bbb8d2b8c5d98feda60 rdf:first sg:person.01163554374.06
85 rdf:rest rdf:nil
86 Ne6a4e96d3a0c4018acb1800962090b6b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
87 schema:name Chemistry, Pharmaceutical
88 rdf:type schema:DefinedTerm
89 Nf69cc0f06f8a440e9b7aef2adabd9639 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
90 schema:name Pharmacokinetics
91 rdf:type schema:DefinedTerm
92 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
93 schema:name Biological Sciences
94 rdf:type schema:DefinedTerm
95 anzsrc-for:0604 schema:inDefinedTermSet anzsrc-for:
96 schema:name Genetics
97 rdf:type schema:DefinedTerm
98 sg:journal.1327423 schema:issn 1474-1776
99 1474-1784
100 schema:name Nature Reviews Drug Discovery
101 rdf:type schema:Periodical
102 sg:person.01025173055.90 schema:affiliation https://www.grid.ac/institutes/grid.418566.8
103 schema:familyName Hopkins
104 schema:givenName Andrew L.
105 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01025173055.90
106 rdf:type schema:Person
107 sg:person.01163554374.06 schema:affiliation https://www.grid.ac/institutes/grid.418566.8
108 schema:familyName Groom
109 schema:givenName Colin R.
110 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01163554374.06
111 rdf:type schema:Person
112 sg:pub.10.1038/35057062 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042854081
113 https://doi.org/10.1038/35057062
114 rdf:type schema:CreativeWork
115 sg:pub.10.1038/81137 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045090002
116 https://doi.org/10.1038/81137
117 rdf:type schema:CreativeWork
118 sg:pub.10.1038/83496 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011462196
119 https://doi.org/10.1038/83496
120 rdf:type schema:CreativeWork
121 sg:pub.10.1038/85627 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016520094
122 https://doi.org/10.1038/85627
123 rdf:type schema:CreativeWork
124 sg:pub.10.1038/nbt1196-1516 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052037467
125 https://doi.org/10.1038/nbt1196-1516
126 rdf:type schema:CreativeWork
127 sg:pub.10.1038/nbt1297-1318 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021256132
128 https://doi.org/10.1038/nbt1297-1318
129 rdf:type schema:CreativeWork
130 https://app.dimensions.ai/details/publication/pub.1083320189 schema:CreativeWork
131 https://doi.org/10.1016/s0169-409x(96)00423-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026263620
132 rdf:type schema:CreativeWork
133 https://doi.org/10.1016/s0958-1669(01)00271-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030159038
134 rdf:type schema:CreativeWork
135 https://doi.org/10.1093/nar/29.1.37 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029793403
136 rdf:type schema:CreativeWork
137 https://doi.org/10.1126/science.1058040 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001517867
138 rdf:type schema:CreativeWork
139 https://doi.org/10.1126/science.1058969 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062444472
140 rdf:type schema:CreativeWork
141 https://doi.org/10.1126/science.287.5460.1960 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062568772
142 rdf:type schema:CreativeWork
143 https://doi.org/10.1126/science.287.5461.2204 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062568860
144 rdf:type schema:CreativeWork
145 https://www.grid.ac/institutes/grid.418566.8 schema:alternateName Pfizer (United Kingdom)
146 schema:name Andrew L. Hopkins and Colin R. Groom are at the Molecular Informatics, Structure and Design Department, Pfizer Global Research & Development, Sandwich, Kent, CT13 9NJ, UK.
147 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...