Protein kinases — the major drug targets of the twenty-first century? View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2002-04

AUTHORS

Philip Cohen

ABSTRACT

Protein phosphorylation regulates most aspects of cell life, whereas abnormal phosphorylation is a cause or consequence of disease. A growing interest in developing orally active protein-kinase inhibitors has recently culminated in the approval of the first of these drugs for clinical use. Protein kinases have now become the second most important group of drug targets, after G-protein-coupled receptors. Here, I give a personal view of some of the most important advances that have shaped this field. More... »

PAGES

309-315

Journal

TITLE

Nature Reviews Drug Discovery

ISSUE

4

VOLUME

1

Author Affiliations

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nrd773

    DOI

    http://dx.doi.org/10.1038/nrd773

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1011169875

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/12120282


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