Novel drug development opportunities for heparin View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2002-02

AUTHORS

Rebecca Lever, Clive P Page

ABSTRACT

The glycosaminoglycan heparin has been used in the clinic as an anticoagulant for more than 50 years. A fully characterized sequence in native heparin is known to be responsible for this activity. However, heparin is a complex polysaccharide, which has an array of properties that are unrelated to its anticoagulant activity. Recent research has provided us with an increased understanding of the specific structural requirements for the various actions of heparin, indicating that it might be possible to create 'tailor-made' sequences based on the heparin template to isolate specific therapeutic activities. This research should provide the basis for novel drug treatments for a range of diseases, including cancer and various inflammatory diseases. More... »

PAGES

140-148

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nrd724

DOI

http://dx.doi.org/10.1038/nrd724

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1014142020

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/12120095


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