Clinical experiences with systemically administered siRNA-based therapeutics in cancer View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2015-12

AUTHORS

Jonathan E. Zuckerman, Mark E. Davis

ABSTRACT

Small interfering RNA (siRNA)-based therapies are emerging as a promising new anticancer approach, and a small number of Phase I clinical trials involving patients with solid tumours have now been completed. Encouraging results from these pioneering clinical studies show that these new therapeutics can successfully and safely inhibit targeted gene products in patients with cancer, and have taught us important lessons regarding appropriate dosages and schedules. In this Review, we critically assess these Phase I studies and discuss their implications for future clinical trial design. Key challenges and future directions in the development of siRNA-containing anticancer therapeutics are also considered. More... »

PAGES

843-856

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    URI

    http://scigraph.springernature.com/pub.10.1038/nrd4685

    DOI

    http://dx.doi.org/10.1038/nrd4685

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1019185606

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/26567702


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