The history and future of targeting cyclin-dependent kinases in cancer therapy View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2015-02

AUTHORS

Uzma Asghar, Agnieszka K. Witkiewicz, Nicholas C. Turner, Erik S. Knudsen

ABSTRACT

Cancer represents a pathological manifestation of uncontrolled cell division; therefore, it has long been anticipated that our understanding of the basic principles of cell cycle control would result in effective cancer therapies. In particular, cyclin-dependent kinases (CDKs) that promote transition through the cell cycle were expected to be key therapeutic targets because many tumorigenic events ultimately drive proliferation by impinging on CDK4 or CDK6 complexes in the G1 phase of the cell cycle. Moreover, perturbations in chromosomal stability and aspects of S phase and G2/M control mediated by CDK2 and CDK1 are pivotal tumorigenic events. Translating this knowledge into successful clinical development of CDK inhibitors has historically been challenging, and numerous CDK inhibitors have demonstrated disappointing results in clinical trials. Here, we review the biology of CDKs, the rationale for therapeutically targeting discrete kinase complexes and historical clinical results of CDK inhibitors. We also discuss how CDK inhibitors with high selectivity (particularly for both CDK4 and CDK6), in combination with patient stratification, have resulted in more substantial clinical activity. More... »

PAGES

130-146

References to SciGraph publications

  • 2009-07. Cell cycle kinases as therapeutic targets for cancer in NATURE REVIEWS DRUG DISCOVERY
  • 2005-10. Ras and Myc can drive oncogenic cell proliferation through individual D-cyclins in ONCOGENE
  • 2005-08. BRAFE600-associated senescence-like cell cycle arrest of human naevi in NATURE
  • 2014-07. Frequent CCNE1 amplification in endometrial intraepithelial carcinoma and uterine serous carcinoma in MODERN PATHOLOGY
  • 2006-03. Cyclin D1: polymorphism, aberrant splicing and cancer risk in ONCOGENE
  • 2002-12. NOBEL LECTURE: Cyclin Dependent Kinases and Cell Cycle Control in BIOSCIENCE REPORTS
  • 2008-02. A phase 1 study of SNS-032 (formerly BMS-387032), a potent inhibitor of cyclin-dependent kinases 2, 7 and 9 administered as a single oral dose and weekly infusion in patients with metastatic refractory solid tumors in INVESTIGATIONAL NEW DRUGS
  • 1995-07. Requirement for tyrosine phosphorylation of Cdk4 in Gl arrest induced by ultraviolet irradiation in NATURE
  • 2001-06. Specific protection against breast cancers by cyclin D1 ablation in NATURE
  • 2013-08. The DREAM complex: master coordinator of cell cycle-dependent gene expression in NATURE REVIEWS CANCER
  • 2002-08. NOBEL LECTURE: Yeast and Cancer in BIOSCIENCE REPORTS
  • 2009-10. PD 0332991, a selective cyclin D kinase 4/6 inhibitor, preferentially inhibits proliferation of luminal estrogen receptor-positive human breast cancer cell lines in vitro in BREAST CANCER RESEARCH
  • 2002-12. NOBEL LECTURE: Protein Synthesis, Proteolysis, and Cell Cycle Transitions in BIOSCIENCE REPORTS
  • 1995-06. Retinoblastoma-protein-dependent cell-cycle inhibition by the tumour suppressor p16 in NATURE
  • 2009-11. Systematic RNA interference reveals that oncogenic KRAS-driven cancers require TBK1 in NATURE
  • 2013-06. CDC25A targeting by miR-483-3p decreases CCND–CDK4/6 assembly and contributes to cell cycle arrest in CELL DEATH & DIFFERENTIATION
  • 2014-06-22. Targeting transcription regulation in cancer with a covalent CDK7 inhibitor in NATURE
  • 2008-09. Tailoring to RB: tumour suppressor status and therapeutic response in NATURE REVIEWS CANCER
  • 1996-12. Cyclin D2 is an FSH-responsive gene involved in gonadal cell proliferation and oncogenesis in NATURE
  • 2013-12. A first-in-human, phase 1, dose-escalation study of dinaciclib, a novel cyclin-dependent kinase inhibitor, administered weekly in subjects with advanced malignancies in JOURNAL OF TRANSLATIONAL MEDICINE
  • 2011-07. Compromised CDK1 activity sensitizes BRCA-proficient cancers to PARP inhibition in NATURE MEDICINE
  • 2008-09. CDK8 is a colorectal cancer oncogene that regulates β-catenin activity in NATURE
  • 2001-04. Regulation of the G2/M transition by p53 in ONCOGENE
  • 1998-10. Understanding the cell cycle in NATURE MEDICINE
  • 1993-12. A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4 in NATURE
  • 2006-05. A unique function for cyclin D3 in early B cell development in NATURE IMMUNOLOGY
  • 2011-06. Phase I study of PD 0332991, a cyclin-dependent kinase inhibitor, administered in 3-week cycles (Schedule 2/1) in BRITISH JOURNAL OF CANCER
  • 2013-01. Inhibition of cyclin-dependent kinase 6 suppresses cell proliferation and enhances radiation sensitivity in medulloblastoma cells in JOURNAL OF NEURO-ONCOLOGY
  • 2007-08. Cdk1 is sufficient to drive the mammalian cell cycle in NATURE
  • 2008-09. Cellular mechanisms of tumour suppression by the retinoblastoma gene in NATURE REVIEWS CANCER
  • 2012-10. Oncogenic NRAS signaling differentially regulates survival and proliferation in melanoma in NATURE MEDICINE
  • 2006-11. Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints in NATURE
  • 2014-12. Targeting cyclin-dependent kinase 1 (CDK1) but not CDK4/6 or CDK2 is selectively lethal to MYC-dependent human breast cancer cells in BMC CANCER
  • 1991-04. A novel cyclin encoded by a bcl1-linked candidate oncogene in NATURE
  • 2009-04. High cyclin B1 expression is associated with poor survival in breast cancer in BRITISH JOURNAL OF CANCER
  • 2001-01. Cell division: Mitotic kinases as regulators of cell division and its checkpoints in NATURE REVIEWS MOLECULAR CELL BIOLOGY
  • 2015-05. Aberrant CDK4 Amplification in Refractory Rhabdomyosarcoma as Identified by Genomic Profiling in SCIENTIFIC REPORTS
  • 1999-06. Regulation of the APC and the exit from mitosis in NATURE CELL BIOLOGY
  • 2008-04. The Cdk inhibitor p27 in human cancer: prognostic potential and relevance to anticancer therapy in NATURE REVIEWS CANCER
  • 1998-09. Structural basis for inhibition of the cyclin-dependent kinase Cdk6 by the tumour suppressor p16INK4a in NATURE
  • 2004-03. The spindle checkpoint, aneuploidy, and cancer in ONCOGENE
  • 2014-06. mTORC1 controls the adaptive transition of quiescent stem cells from G0 to GAlert in NATURE
  • 2013-11. Targeting cell cycle and hormone receptor pathways in cancer in ONCOGENE
  • 2001-12. Milestones in cell division : To cycle or not to cycle: a critical decision in cancer in NATURE REVIEWS CANCER
  • 2010-07. Therapeutic CDK4/6 inhibition in breast cancer: key mechanisms of response and failure in ONCOGENE
  • 2014-10. Preclinical characterization of the CDK4/6 inhibitor LY2835219: in-vivo cell cycle-dependent/independent anti-tumor activities alone/in combination with gemcitabine in INVESTIGATIONAL NEW DRUGS
  • 2011-09. Risk factors for tumor lysis syndrome in patients with chronic lymphocytic leukemia treated with the cyclin-dependent kinase inhibitor, flavopiridol in LEUKEMIA
  • 2006-06. Therapeutic opportunities to control tumor cell cycles in CLINICAL AND TRANSLATIONAL ONCOLOGY
  • 2000-09. TFIIH is negatively regulated by cdk8-containing mediator complexes in NATURE
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nrd4504

    DOI

    http://dx.doi.org/10.1038/nrd4504

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1021914398

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/25633797


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Biochemistry and Cell Biology", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Biological Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Animals", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Antineoplastic Agents", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cell Cycle", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Clinical Trials as Topic", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cyclin-Dependent Kinases", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Drug Discovery", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Drug Evaluation, Preclinical", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Gene Expression Regulation, Neoplastic", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Molecular Structure", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Molecular Targeted Therapy", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Neoplasms", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Signal Transduction", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Institute of Cancer Research", 
              "id": "https://www.grid.ac/institutes/grid.18886.3f", 
              "name": [
                "Breakthrough Breast Cancer Research Centre, Chester Beatty Laboratories, Institute of Cancer Research, London, SW3 6JB, UK."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Asghar", 
            "givenName": "Uzma", 
            "id": "sg:person.01332017567.61", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01332017567.61"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "The University of Texas Southwestern Medical Center", 
              "id": "https://www.grid.ac/institutes/grid.267313.2", 
              "name": [
                "Simmons Cancer Center and Department of Pathology, University of Texas Southwestern, Dallas, USA."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Witkiewicz", 
            "givenName": "Agnieszka K.", 
            "id": "sg:person.07430571417.64", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07430571417.64"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Institute of Cancer Research", 
              "id": "https://www.grid.ac/institutes/grid.18886.3f", 
              "name": [
                "Institute of Cancer Research and Royal Marsden NHS Foundation Trust Breast Cancer Unit, London, SW3 6JJ, UK."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Turner", 
            "givenName": "Nicholas C.", 
            "id": "sg:person.0747361420.45", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0747361420.45"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "The University of Texas Southwestern Medical Center", 
              "id": "https://www.grid.ac/institutes/grid.267313.2", 
              "name": [
                "Simmons Cancer Center and Department of Pathology, University of Texas Southwestern, Dallas, USA."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Knudsen", 
            "givenName": "Erik S.", 
            "id": "sg:person.0673403506.86", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0673403506.86"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "https://doi.org/10.1128/mcb.21.12.4032-4045.2001", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000076084"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gad.7.3.331", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000187410"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3109/10428194.2013.783911", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000221542"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0968-0004(00)89005-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001616450"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1471-2407-14-32", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001663760", 
              "https://doi.org/10.1186/1471-2407-14-32"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/ijc.25091", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001817106"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/ijc.25091", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001817106"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature08460", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002209653", 
              "https://doi.org/10.1038/nature08460"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature08460", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002209653", 
              "https://doi.org/10.1038/nature08460"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gad.181933.111", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002261620"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1200/jco.2009.24.1570", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002424810"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.onc.1208853", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002551576", 
              "https://doi.org/10.1038/sj.onc.1208853"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.onc.1208853", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002551576", 
              "https://doi.org/10.1038/sj.onc.1208853"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.onc.1208853", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002551576", 
              "https://doi.org/10.1038/sj.onc.1208853"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1200/jco.2014.57.1505", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003044785"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejmc0808558", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003112265"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature03890", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003324113", 
              "https://doi.org/10.1038/nature03890"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature03890", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003324113", 
              "https://doi.org/10.1038/nature03890"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature03890", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003324113", 
              "https://doi.org/10.1038/nature03890"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/384470a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003821351", 
              "https://doi.org/10.1038/384470a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0092-8674(94)90572-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004129838"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/0008-5472.can-13-2247", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004952509"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/1535-7163.mct-08-0836", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005785454"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gad.244368.114", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006327592"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1038/sj.emboj.7600459", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006859251"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gad.7.8.1572", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007024026"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/0008-5472.can-08-2473", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007120419"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/2159-8290.cd-11-0320", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007349245"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/mcb.25.9.3752-3762.2005", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007364154"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/onc.2013.83", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007412704", 
              "https://doi.org/10.1038/onc.2013.83"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/1535-7163.mct-14-0387", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007772039"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.18632/oncotarget.2270", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007950724"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/bjc.2011.177", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008185187", 
              "https://doi.org/10.1038/bjc.2011.177"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1182/blood-2011-10-388298", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008456233"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.clbc.2013.10.016", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008611099"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/10039", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008891532", 
              "https://doi.org/10.1038/10039"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/10039", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008891532", 
              "https://doi.org/10.1038/10039"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1470-2045(08)70208-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010029253"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1006/excr.1996.0356", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010695968"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature07179", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010877750", 
              "https://doi.org/10.1038/nature07179"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1200/jco.2012.46.5476", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010996175"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.1001613107", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011006242"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0092-8674(91)90101-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011021705"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/jnci/djs002", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011154852"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/cdd.2013.5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011666985", 
              "https://doi.org/10.1038/cdd.2013.5"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gad.949802", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012307300"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0955-0674(00)00278-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012858292"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/mcb.16.5.2402", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013138584"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gad.11.8.957", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013487101"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ccr.2012.09.016", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013646138"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/1078-0432.ccr-10-2307", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013878313"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gad.12.15.2278", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014014091"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/mcb.14.3.2066", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014240465"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.biocel.2003.12.005", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014247138"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/onc.2010.154", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014304136", 
              "https://doi.org/10.1038/onc.2010.154"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/onc.2010.154", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014304136", 
              "https://doi.org/10.1038/onc.2010.154"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m112.365494", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014575863"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm.2941", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014975189", 
              "https://doi.org/10.1038/nm.2941"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/350512a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014976902", 
              "https://doi.org/10.1038/350512a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm.2377", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015593189", 
              "https://doi.org/10.1038/nm.2377"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.95.3.1091", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015650254"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/mcb.25.24.10875-10894.2005", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015716676"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/366704a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015821919", 
              "https://doi.org/10.1038/366704a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrc2401", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015933644", 
              "https://doi.org/10.1038/nrc2401"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.93.20.11173", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016453679"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/ijc.2910570311", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016789275"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.onc.1209371", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017363890", 
              "https://doi.org/10.1038/sj.onc.1209371"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.onc.1209371", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017363890", 
              "https://doi.org/10.1038/sj.onc.1209371"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ni1324", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017614572", 
              "https://doi.org/10.1038/ni1324"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ni1324", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017614572", 
              "https://doi.org/10.1038/ni1324"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1200/jco.2013.52.3993", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019615393"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gad.829500", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019696649"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1006/excr.1997.3776", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019832759"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.lungcan.2013.11.020", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020719059"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s11060-012-1000-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021196540", 
              "https://doi.org/10.1007/s11060-012-1000-7"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1517/13543784.9.12.2903", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021216762"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.1314302110", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021403484"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.biochi.2013.10.004", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022013368"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1182/blood-2006-05-020735", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022560846"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s12094-006-0193-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022594533", 
              "https://doi.org/10.1007/s12094-006-0193-7"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/1541-7786.mcr-13-0350", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023218390"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0077639", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023410146"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ejca.2010.08.001", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024294569"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature13255", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024625107", 
              "https://doi.org/10.1038/nature13255"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.18632/genesandcancer.24", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024841874"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/2594", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025173151", 
              "https://doi.org/10.1038/2594"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/2594", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025173151", 
              "https://doi.org/10.1038/2594"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/376358a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025277798", 
              "https://doi.org/10.1038/376358a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/srep03623", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025370301", 
              "https://doi.org/10.1038/srep03623"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/annonc/mdp377", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025440152"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/1078-0432.ccr-13-1675", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025477028"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10637-014-0120-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025489180", 
              "https://doi.org/10.1007/s10637-014-0120-7"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10637-014-0120-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025489180", 
              "https://doi.org/10.1007/s10637-014-0120-7"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1479-5876-11-259", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025904273", 
              "https://doi.org/10.1186/1479-5876-11-259"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0092-8674(00)81902-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026392285"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/pcmr.12228", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027259447"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1053/j.gastro.2010.01.007", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028001058"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ccr.2013.08.027", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028309133"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/0008-5472.can-13-2923", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028370514"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.bjc.6604874", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028475821", 
              "https://doi.org/10.1038/sj.bjc.6604874"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.bjc.6604874", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028475821", 
              "https://doi.org/10.1038/sj.bjc.6604874"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2004.08.002", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028831364"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1083/jcb.152.5.945", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028936756"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gad.13.12.1501", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029101666"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gad.9.15.1831", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029170181"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/35106065", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029289076", 
              "https://doi.org/10.1038/35106065"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/35106065", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029289076", 
              "https://doi.org/10.1038/35106065"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/modpathol.2013.209", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029415400", 
              "https://doi.org/10.1038/modpathol.2013.209"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/1078-0432.ccr-13-2846", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029418890"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0065-230x(08)60834-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029640191"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ccr.2012.09.015", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030170421"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/1535-7163.mct-12-0562", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030663352"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1182/blood-2006-04-016634", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031278800"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1530/erc-10-0262", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031547310"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gad.851100", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031575679"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0955-0674(98)80121-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031728193"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.101004498", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032439010"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1098/rstb.2011.0274", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032451639"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1200/jco.2009.26.1347", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032892538"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrc2399", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033037679", 
              "https://doi.org/10.1038/nrc2399"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/1078-0432.ccr-13-1551", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033297283"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/1535-7163.mct-14-0257", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033447415"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/26155", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034157082", 
              "https://doi.org/10.1038/26155"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/26155", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034157082", 
              "https://doi.org/10.1038/26155"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/35082500", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034302480", 
              "https://doi.org/10.1038/35082500"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/35082500", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034302480", 
              "https://doi.org/10.1038/35082500"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/375503a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034728495", 
              "https://doi.org/10.1038/375503a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1006/jmbi.1999.2640", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035214587"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gad.12.22.3499", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035234284"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1517/13543784.2013.789859", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035512702"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/mcb.15.5.2600", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035576061"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrd2907", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035577861", 
              "https://doi.org/10.1038/nrd2907"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrd2907", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035577861", 
              "https://doi.org/10.1038/nrd2907"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/35024111", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036793227", 
              "https://doi.org/10.1038/35024111"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/35024111", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036793227", 
              "https://doi.org/10.1038/35024111"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature06046", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037045843", 
              "https://doi.org/10.1038/nature06046"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1023/a:1022017701871", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037369236", 
              "https://doi.org/10.1023/a:1022017701871"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.18632/oncotarget.1568", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037907473"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gad.1023602", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037936691"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2217/fon.10.144", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038505714"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0092-8674(93)90500-p", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038576682"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0092-8674(87)90227-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039798489"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature05268", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039813470", 
              "https://doi.org/10.1038/nature05268"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature05268", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039813470", 
              "https://doi.org/10.1038/nature05268"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature05268", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039813470", 
              "https://doi.org/10.1038/nature05268"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.onc.1207374", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040628523", 
              "https://doi.org/10.1038/sj.onc.1207374"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.onc.1207374", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040628523", 
              "https://doi.org/10.1038/sj.onc.1207374"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/1535-7163.mct-11-0963", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040775130"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ccr.2014.05.020", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041312538"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/1535-7163.mct-10-0324", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041876141"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2004.07.025", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042154429"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2012.12.010", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042391763"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1023/a:1020918107706", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042929581", 
              "https://doi.org/10.1023/a:1020918107706"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature13393", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043379007", 
              "https://doi.org/10.1038/nature13393"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/0008-5472.can-03-0110", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043727339"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1242/dev.091744", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043847173"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/leu.2011.109", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043900277", 
              "https://doi.org/10.1038/leu.2011.109"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m600197200", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044159237"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0092-8674(00)00093-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044284876"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1023/a:1022077317801", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044718571", 
              "https://doi.org/10.1023/a:1022077317801"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10637-007-9090-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044972352", 
              "https://doi.org/10.1007/s10637-007-9090-3"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/0008-5472.can-05-2507", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045773698"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.devcel.2010.02.013", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045788636"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ccr.2010.05.025", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045887142"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.93.13.6488", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045895978"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.98.4.1682", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046239571"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrc2347", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046912140", 
              "https://doi.org/10.1038/nrc2347"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrc3556", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047168268", 
              "https://doi.org/10.1038/nrc3556"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/2159-8290.cd-11-0101", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047359970"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.onc.1204252", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047429381", 
              "https://doi.org/10.1038/sj.onc.1204252"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.onc.1204252", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047429381", 
              "https://doi.org/10.1038/sj.onc.1204252"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/0008-5472.can-07-6404", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047891167"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/1078-0432.ccr-11-0244", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048281007"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1200/jco.2013.48.6837", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048428719"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gad.11.11.1479", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048904790"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/0008-5472.can-09-4559", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048912946"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/bcr2419", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050281960", 
              "https://doi.org/10.1186/bcr2419"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/1078-0432.ccr-11-0509", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050917004"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.92.19.8871", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051442757"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/35048096", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051541099", 
              "https://doi.org/10.1038/35048096"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/35048096", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051541099", 
              "https://doi.org/10.1038/35048096"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ccr.2011.10.001", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052152545"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/0008-5472.can-04-1613", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052185856"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1083/jcb.200909144", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052347020"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gad.8.1.9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052772922"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/1535-7163.mct-06-0355", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053015591"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.1014835108", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053239509"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1470-2045(14)71159-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053530404"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/jm0305568", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1055948192"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/jm0305568", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1055948192"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/jm049354h", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1055949017"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/jm049354h", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1055949017"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/jm049355+", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1055949018"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/jm049355+", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1055949018"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.274.5293.1672", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062555127"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.8266103", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062653911"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/0008-5472.sabcs12-s1-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1063222235"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/1538-7445.am2014-ct101", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1063259112"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/2159-8290.cd-nb2014-098", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1063281332"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1200/jco.2005.03.7689", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064204223"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1200/jco.2003.09.057", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064205102"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2741/bregman", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1070917737"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3892/ijo.9.6.1143", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1071517962"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4161/auto.23027", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1072289687"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4161/cbt.72", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1072295096"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4161/cc.10.15.16776", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1072296024"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4161/cc.21127", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1072296943"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4161/cc.21195", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1072296947"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4161/cc.4.3.1551", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1072298251"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4161/cc.5.19.3254", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1072298621"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1074889471", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1075114599", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1075192384", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1076885269", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1076965945", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1078763285", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1082708534", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1082763127", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1082903096", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1200/jco.1998.16.9.2986", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1083316819"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1200/jco.2010.28.15_suppl.3060", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1083942939"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2015-02", 
        "datePublishedReg": "2015-02-01", 
        "description": "Cancer represents a pathological manifestation of uncontrolled cell division; therefore, it has long been anticipated that our understanding of the basic principles of cell cycle control would result in effective cancer therapies. In particular, cyclin-dependent kinases (CDKs) that promote transition through the cell cycle were expected to be key therapeutic targets because many tumorigenic events ultimately drive proliferation by impinging on CDK4 or CDK6 complexes in the G1 phase of the cell cycle. Moreover, perturbations in chromosomal stability and aspects of S phase and G2/M control mediated by CDK2 and CDK1 are pivotal tumorigenic events. Translating this knowledge into successful clinical development of CDK inhibitors has historically been challenging, and numerous CDK inhibitors have demonstrated disappointing results in clinical trials. Here, we review the biology of CDKs, the rationale for therapeutically targeting discrete kinase complexes and historical clinical results of CDK inhibitors. We also discuss how CDK inhibitors with high selectivity (particularly for both CDK4 and CDK6), in combination with patient stratification, have resulted in more substantial clinical activity. ", 
        "genre": "research_article", 
        "id": "sg:pub.10.1038/nrd4504", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": true, 
        "isFundedItemOf": [
          {
            "id": "sg:grant.2479434", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2481711", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.3806113", 
            "type": "MonetaryGrant"
          }
        ], 
        "isPartOf": [
          {
            "id": "sg:journal.1327423", 
            "issn": [
              "1474-1776", 
              "1474-1784"
            ], 
            "name": "Nature Reviews Drug Discovery", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "2", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "14"
          }
        ], 
        "name": "The history and future of targeting cyclin-dependent kinases in cancer therapy", 
        "pagination": "130-146", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "686795d817f096c7ae5f66608325d117549065e66a5a9e63b2d3fd9adea69f67"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "25633797"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "101124171"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1038/nrd4504"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1021914398"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1038/nrd4504", 
          "https://app.dimensions.ai/details/publication/pub.1021914398"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-10T19:45", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8681_00000424.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "http://www.nature.com/nrd/journal/v14/n2/full/nrd4504.html"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/nrd4504'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/nrd4504'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/nrd4504'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/nrd4504'


     

    This table displays all metadata directly associated to this object as RDF triples.

    777 TRIPLES      21 PREDICATES      237 URIs      34 LITERALS      22 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1038/nrd4504 schema:about N07392dc9e421492d828c5f5bad7ba0bc
    2 N0d15722327dd4749b2e71303713dbd9e
    3 N1fe3eb1a5fc4458a9c06cc0dad5f134b
    4 N24d9e7a610784fe59073ba3d99b8c697
    5 N28f29139e3b947cba951411051659558
    6 N2fb940c8532a430994d2af8411986ecf
    7 N613ba93eb48444368405498c0df746d8
    8 N661b614933264822bebbd9c6419a9bc3
    9 N94142031acc04c98ae5501f6b57d24bf
    10 N98526957b52246f78ed574eca26568db
    11 Ne8d5eed0d61e40319fe12af9e651acd0
    12 Nefe78c3369c04a1aa860468e4ac4e7f4
    13 Nf37ae95ddc4c45719f9806b9256dda74
    14 anzsrc-for:06
    15 anzsrc-for:0601
    16 schema:author Nd028f4ba73f24112bd25a105df20c314
    17 schema:citation sg:pub.10.1007/s10637-007-9090-3
    18 sg:pub.10.1007/s10637-014-0120-7
    19 sg:pub.10.1007/s11060-012-1000-7
    20 sg:pub.10.1007/s12094-006-0193-7
    21 sg:pub.10.1023/a:1020918107706
    22 sg:pub.10.1023/a:1022017701871
    23 sg:pub.10.1023/a:1022077317801
    24 sg:pub.10.1038/10039
    25 sg:pub.10.1038/2594
    26 sg:pub.10.1038/26155
    27 sg:pub.10.1038/35024111
    28 sg:pub.10.1038/35048096
    29 sg:pub.10.1038/350512a0
    30 sg:pub.10.1038/35082500
    31 sg:pub.10.1038/35106065
    32 sg:pub.10.1038/366704a0
    33 sg:pub.10.1038/375503a0
    34 sg:pub.10.1038/376358a0
    35 sg:pub.10.1038/384470a0
    36 sg:pub.10.1038/bjc.2011.177
    37 sg:pub.10.1038/cdd.2013.5
    38 sg:pub.10.1038/leu.2011.109
    39 sg:pub.10.1038/modpathol.2013.209
    40 sg:pub.10.1038/nature03890
    41 sg:pub.10.1038/nature05268
    42 sg:pub.10.1038/nature06046
    43 sg:pub.10.1038/nature07179
    44 sg:pub.10.1038/nature08460
    45 sg:pub.10.1038/nature13255
    46 sg:pub.10.1038/nature13393
    47 sg:pub.10.1038/ni1324
    48 sg:pub.10.1038/nm.2377
    49 sg:pub.10.1038/nm.2941
    50 sg:pub.10.1038/nrc2347
    51 sg:pub.10.1038/nrc2399
    52 sg:pub.10.1038/nrc2401
    53 sg:pub.10.1038/nrc3556
    54 sg:pub.10.1038/nrd2907
    55 sg:pub.10.1038/onc.2010.154
    56 sg:pub.10.1038/onc.2013.83
    57 sg:pub.10.1038/sj.bjc.6604874
    58 sg:pub.10.1038/sj.onc.1204252
    59 sg:pub.10.1038/sj.onc.1207374
    60 sg:pub.10.1038/sj.onc.1208853
    61 sg:pub.10.1038/sj.onc.1209371
    62 sg:pub.10.1038/srep03623
    63 sg:pub.10.1186/1471-2407-14-32
    64 sg:pub.10.1186/1479-5876-11-259
    65 sg:pub.10.1186/bcr2419
    66 https://app.dimensions.ai/details/publication/pub.1074889471
    67 https://app.dimensions.ai/details/publication/pub.1075114599
    68 https://app.dimensions.ai/details/publication/pub.1075192384
    69 https://app.dimensions.ai/details/publication/pub.1076885269
    70 https://app.dimensions.ai/details/publication/pub.1076965945
    71 https://app.dimensions.ai/details/publication/pub.1078763285
    72 https://app.dimensions.ai/details/publication/pub.1082708534
    73 https://app.dimensions.ai/details/publication/pub.1082763127
    74 https://app.dimensions.ai/details/publication/pub.1082903096
    75 https://doi.org/10.1002/ijc.25091
    76 https://doi.org/10.1002/ijc.2910570311
    77 https://doi.org/10.1006/excr.1996.0356
    78 https://doi.org/10.1006/excr.1997.3776
    79 https://doi.org/10.1006/jmbi.1999.2640
    80 https://doi.org/10.1016/0092-8674(87)90227-3
    81 https://doi.org/10.1016/0092-8674(91)90101-4
    82 https://doi.org/10.1016/0092-8674(93)90500-p
    83 https://doi.org/10.1016/0092-8674(94)90572-x
    84 https://doi.org/10.1016/j.biocel.2003.12.005
    85 https://doi.org/10.1016/j.biochi.2013.10.004
    86 https://doi.org/10.1016/j.ccr.2010.05.025
    87 https://doi.org/10.1016/j.ccr.2011.10.001
    88 https://doi.org/10.1016/j.ccr.2012.09.015
    89 https://doi.org/10.1016/j.ccr.2012.09.016
    90 https://doi.org/10.1016/j.ccr.2013.08.027
    91 https://doi.org/10.1016/j.ccr.2014.05.020
    92 https://doi.org/10.1016/j.cell.2004.07.025
    93 https://doi.org/10.1016/j.cell.2004.08.002
    94 https://doi.org/10.1016/j.cell.2012.12.010
    95 https://doi.org/10.1016/j.clbc.2013.10.016
    96 https://doi.org/10.1016/j.devcel.2010.02.013
    97 https://doi.org/10.1016/j.ejca.2010.08.001
    98 https://doi.org/10.1016/j.lungcan.2013.11.020
    99 https://doi.org/10.1016/s0065-230x(08)60834-9
    100 https://doi.org/10.1016/s0092-8674(00)00093-3
    101 https://doi.org/10.1016/s0092-8674(00)81902-9
    102 https://doi.org/10.1016/s0955-0674(00)00278-7
    103 https://doi.org/10.1016/s0955-0674(98)80121-x
    104 https://doi.org/10.1016/s0968-0004(00)89005-2
    105 https://doi.org/10.1016/s1470-2045(08)70208-0
    106 https://doi.org/10.1016/s1470-2045(14)71159-3
    107 https://doi.org/10.1021/jm0305568
    108 https://doi.org/10.1021/jm049354h
    109 https://doi.org/10.1021/jm049355+
    110 https://doi.org/10.1038/sj.emboj.7600459
    111 https://doi.org/10.1053/j.gastro.2010.01.007
    112 https://doi.org/10.1056/nejmc0808558
    113 https://doi.org/10.1073/pnas.1001613107
    114 https://doi.org/10.1073/pnas.101004498
    115 https://doi.org/10.1073/pnas.1014835108
    116 https://doi.org/10.1073/pnas.1314302110
    117 https://doi.org/10.1073/pnas.92.19.8871
    118 https://doi.org/10.1073/pnas.93.13.6488
    119 https://doi.org/10.1073/pnas.93.20.11173
    120 https://doi.org/10.1073/pnas.95.3.1091
    121 https://doi.org/10.1073/pnas.98.4.1682
    122 https://doi.org/10.1074/jbc.m112.365494
    123 https://doi.org/10.1074/jbc.m600197200
    124 https://doi.org/10.1083/jcb.152.5.945
    125 https://doi.org/10.1083/jcb.200909144
    126 https://doi.org/10.1093/annonc/mdp377
    127 https://doi.org/10.1093/jnci/djs002
    128 https://doi.org/10.1098/rstb.2011.0274
    129 https://doi.org/10.1101/gad.1023602
    130 https://doi.org/10.1101/gad.11.11.1479
    131 https://doi.org/10.1101/gad.11.8.957
    132 https://doi.org/10.1101/gad.12.15.2278
    133 https://doi.org/10.1101/gad.12.22.3499
    134 https://doi.org/10.1101/gad.13.12.1501
    135 https://doi.org/10.1101/gad.181933.111
    136 https://doi.org/10.1101/gad.244368.114
    137 https://doi.org/10.1101/gad.7.3.331
    138 https://doi.org/10.1101/gad.7.8.1572
    139 https://doi.org/10.1101/gad.8.1.9
    140 https://doi.org/10.1101/gad.829500
    141 https://doi.org/10.1101/gad.851100
    142 https://doi.org/10.1101/gad.9.15.1831
    143 https://doi.org/10.1101/gad.949802
    144 https://doi.org/10.1111/pcmr.12228
    145 https://doi.org/10.1126/science.274.5293.1672
    146 https://doi.org/10.1126/science.8266103
    147 https://doi.org/10.1128/mcb.14.3.2066
    148 https://doi.org/10.1128/mcb.15.5.2600
    149 https://doi.org/10.1128/mcb.16.5.2402
    150 https://doi.org/10.1128/mcb.21.12.4032-4045.2001
    151 https://doi.org/10.1128/mcb.25.24.10875-10894.2005
    152 https://doi.org/10.1128/mcb.25.9.3752-3762.2005
    153 https://doi.org/10.1158/0008-5472.can-03-0110
    154 https://doi.org/10.1158/0008-5472.can-04-1613
    155 https://doi.org/10.1158/0008-5472.can-05-2507
    156 https://doi.org/10.1158/0008-5472.can-07-6404
    157 https://doi.org/10.1158/0008-5472.can-08-2473
    158 https://doi.org/10.1158/0008-5472.can-09-4559
    159 https://doi.org/10.1158/0008-5472.can-13-2247
    160 https://doi.org/10.1158/0008-5472.can-13-2923
    161 https://doi.org/10.1158/0008-5472.sabcs12-s1-6
    162 https://doi.org/10.1158/1078-0432.ccr-10-2307
    163 https://doi.org/10.1158/1078-0432.ccr-11-0244
    164 https://doi.org/10.1158/1078-0432.ccr-11-0509
    165 https://doi.org/10.1158/1078-0432.ccr-13-1551
    166 https://doi.org/10.1158/1078-0432.ccr-13-1675
    167 https://doi.org/10.1158/1078-0432.ccr-13-2846
    168 https://doi.org/10.1158/1535-7163.mct-06-0355
    169 https://doi.org/10.1158/1535-7163.mct-08-0836
    170 https://doi.org/10.1158/1535-7163.mct-10-0324
    171 https://doi.org/10.1158/1535-7163.mct-11-0963
    172 https://doi.org/10.1158/1535-7163.mct-12-0562
    173 https://doi.org/10.1158/1535-7163.mct-14-0257
    174 https://doi.org/10.1158/1535-7163.mct-14-0387
    175 https://doi.org/10.1158/1538-7445.am2014-ct101
    176 https://doi.org/10.1158/1541-7786.mcr-13-0350
    177 https://doi.org/10.1158/2159-8290.cd-11-0101
    178 https://doi.org/10.1158/2159-8290.cd-11-0320
    179 https://doi.org/10.1158/2159-8290.cd-nb2014-098
    180 https://doi.org/10.1182/blood-2006-04-016634
    181 https://doi.org/10.1182/blood-2006-05-020735
    182 https://doi.org/10.1182/blood-2011-10-388298
    183 https://doi.org/10.1200/jco.1998.16.9.2986
    184 https://doi.org/10.1200/jco.2003.09.057
    185 https://doi.org/10.1200/jco.2005.03.7689
    186 https://doi.org/10.1200/jco.2009.24.1570
    187 https://doi.org/10.1200/jco.2009.26.1347
    188 https://doi.org/10.1200/jco.2010.28.15_suppl.3060
    189 https://doi.org/10.1200/jco.2012.46.5476
    190 https://doi.org/10.1200/jco.2013.48.6837
    191 https://doi.org/10.1200/jco.2013.52.3993
    192 https://doi.org/10.1200/jco.2014.57.1505
    193 https://doi.org/10.1242/dev.091744
    194 https://doi.org/10.1371/journal.pone.0077639
    195 https://doi.org/10.1517/13543784.2013.789859
    196 https://doi.org/10.1517/13543784.9.12.2903
    197 https://doi.org/10.1530/erc-10-0262
    198 https://doi.org/10.18632/genesandcancer.24
    199 https://doi.org/10.18632/oncotarget.1568
    200 https://doi.org/10.18632/oncotarget.2270
    201 https://doi.org/10.2217/fon.10.144
    202 https://doi.org/10.2741/bregman
    203 https://doi.org/10.3109/10428194.2013.783911
    204 https://doi.org/10.3892/ijo.9.6.1143
    205 https://doi.org/10.4161/auto.23027
    206 https://doi.org/10.4161/cbt.72
    207 https://doi.org/10.4161/cc.10.15.16776
    208 https://doi.org/10.4161/cc.21127
    209 https://doi.org/10.4161/cc.21195
    210 https://doi.org/10.4161/cc.4.3.1551
    211 https://doi.org/10.4161/cc.5.19.3254
    212 schema:datePublished 2015-02
    213 schema:datePublishedReg 2015-02-01
    214 schema:description Cancer represents a pathological manifestation of uncontrolled cell division; therefore, it has long been anticipated that our understanding of the basic principles of cell cycle control would result in effective cancer therapies. In particular, cyclin-dependent kinases (CDKs) that promote transition through the cell cycle were expected to be key therapeutic targets because many tumorigenic events ultimately drive proliferation by impinging on CDK4 or CDK6 complexes in the G1 phase of the cell cycle. Moreover, perturbations in chromosomal stability and aspects of S phase and G2/M control mediated by CDK2 and CDK1 are pivotal tumorigenic events. Translating this knowledge into successful clinical development of CDK inhibitors has historically been challenging, and numerous CDK inhibitors have demonstrated disappointing results in clinical trials. Here, we review the biology of CDKs, the rationale for therapeutically targeting discrete kinase complexes and historical clinical results of CDK inhibitors. We also discuss how CDK inhibitors with high selectivity (particularly for both CDK4 and CDK6), in combination with patient stratification, have resulted in more substantial clinical activity.
    215 schema:genre research_article
    216 schema:inLanguage en
    217 schema:isAccessibleForFree true
    218 schema:isPartOf N29fdaeec370b4c5cace15e2bcff1f999
    219 N9d9f2b85fb7e4cb784fb37101acdc5c5
    220 sg:journal.1327423
    221 schema:name The history and future of targeting cyclin-dependent kinases in cancer therapy
    222 schema:pagination 130-146
    223 schema:productId N4a412d708b7f431aabc37f308740251d
    224 N4d57c51d98b945229961a7ae60aecc11
    225 N6151f5f591c04cdf9dc26b9b96094761
    226 N8835c6df175f432898930bda6294bc67
    227 Nf7225388621e459a88d027b558058f19
    228 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021914398
    229 https://doi.org/10.1038/nrd4504
    230 schema:sdDatePublished 2019-04-10T19:45
    231 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    232 schema:sdPublisher N2997eb2944c0429994479fd6baff3988
    233 schema:url http://www.nature.com/nrd/journal/v14/n2/full/nrd4504.html
    234 sgo:license sg:explorer/license/
    235 sgo:sdDataset articles
    236 rdf:type schema:ScholarlyArticle
    237 N07392dc9e421492d828c5f5bad7ba0bc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    238 schema:name Antineoplastic Agents
    239 rdf:type schema:DefinedTerm
    240 N0d15722327dd4749b2e71303713dbd9e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    241 schema:name Clinical Trials as Topic
    242 rdf:type schema:DefinedTerm
    243 N1036277d1082488ab5bd6e2fbbf5539e rdf:first sg:person.0673403506.86
    244 rdf:rest rdf:nil
    245 N1fe3eb1a5fc4458a9c06cc0dad5f134b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    246 schema:name Humans
    247 rdf:type schema:DefinedTerm
    248 N24d9e7a610784fe59073ba3d99b8c697 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    249 schema:name Molecular Targeted Therapy
    250 rdf:type schema:DefinedTerm
    251 N28f29139e3b947cba951411051659558 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    252 schema:name Signal Transduction
    253 rdf:type schema:DefinedTerm
    254 N2997eb2944c0429994479fd6baff3988 schema:name Springer Nature - SN SciGraph project
    255 rdf:type schema:Organization
    256 N29fdaeec370b4c5cace15e2bcff1f999 schema:issueNumber 2
    257 rdf:type schema:PublicationIssue
    258 N2fb940c8532a430994d2af8411986ecf schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    259 schema:name Molecular Structure
    260 rdf:type schema:DefinedTerm
    261 N4a412d708b7f431aabc37f308740251d schema:name nlm_unique_id
    262 schema:value 101124171
    263 rdf:type schema:PropertyValue
    264 N4d57c51d98b945229961a7ae60aecc11 schema:name dimensions_id
    265 schema:value pub.1021914398
    266 rdf:type schema:PropertyValue
    267 N613ba93eb48444368405498c0df746d8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    268 schema:name Cyclin-Dependent Kinases
    269 rdf:type schema:DefinedTerm
    270 N6151f5f591c04cdf9dc26b9b96094761 schema:name pubmed_id
    271 schema:value 25633797
    272 rdf:type schema:PropertyValue
    273 N661b614933264822bebbd9c6419a9bc3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    274 schema:name Drug Evaluation, Preclinical
    275 rdf:type schema:DefinedTerm
    276 N8835c6df175f432898930bda6294bc67 schema:name doi
    277 schema:value 10.1038/nrd4504
    278 rdf:type schema:PropertyValue
    279 N94142031acc04c98ae5501f6b57d24bf schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    280 schema:name Cell Cycle
    281 rdf:type schema:DefinedTerm
    282 N98526957b52246f78ed574eca26568db schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    283 schema:name Animals
    284 rdf:type schema:DefinedTerm
    285 N9d9f2b85fb7e4cb784fb37101acdc5c5 schema:volumeNumber 14
    286 rdf:type schema:PublicationVolume
    287 Nb8d0c638a84b4c3b98c69a3faa709d9e rdf:first sg:person.0747361420.45
    288 rdf:rest N1036277d1082488ab5bd6e2fbbf5539e
    289 Nd028f4ba73f24112bd25a105df20c314 rdf:first sg:person.01332017567.61
    290 rdf:rest Nfddf02beffd140ff97d51870d437f4de
    291 Ne8d5eed0d61e40319fe12af9e651acd0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    292 schema:name Neoplasms
    293 rdf:type schema:DefinedTerm
    294 Nefe78c3369c04a1aa860468e4ac4e7f4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    295 schema:name Gene Expression Regulation, Neoplastic
    296 rdf:type schema:DefinedTerm
    297 Nf37ae95ddc4c45719f9806b9256dda74 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    298 schema:name Drug Discovery
    299 rdf:type schema:DefinedTerm
    300 Nf7225388621e459a88d027b558058f19 schema:name readcube_id
    301 schema:value 686795d817f096c7ae5f66608325d117549065e66a5a9e63b2d3fd9adea69f67
    302 rdf:type schema:PropertyValue
    303 Nfddf02beffd140ff97d51870d437f4de rdf:first sg:person.07430571417.64
    304 rdf:rest Nb8d0c638a84b4c3b98c69a3faa709d9e
    305 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
    306 schema:name Biological Sciences
    307 rdf:type schema:DefinedTerm
    308 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
    309 schema:name Biochemistry and Cell Biology
    310 rdf:type schema:DefinedTerm
    311 sg:grant.2479434 http://pending.schema.org/fundedItem sg:pub.10.1038/nrd4504
    312 rdf:type schema:MonetaryGrant
    313 sg:grant.2481711 http://pending.schema.org/fundedItem sg:pub.10.1038/nrd4504
    314 rdf:type schema:MonetaryGrant
    315 sg:grant.3806113 http://pending.schema.org/fundedItem sg:pub.10.1038/nrd4504
    316 rdf:type schema:MonetaryGrant
    317 sg:journal.1327423 schema:issn 1474-1776
    318 1474-1784
    319 schema:name Nature Reviews Drug Discovery
    320 rdf:type schema:Periodical
    321 sg:person.01332017567.61 schema:affiliation https://www.grid.ac/institutes/grid.18886.3f
    322 schema:familyName Asghar
    323 schema:givenName Uzma
    324 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01332017567.61
    325 rdf:type schema:Person
    326 sg:person.0673403506.86 schema:affiliation https://www.grid.ac/institutes/grid.267313.2
    327 schema:familyName Knudsen
    328 schema:givenName Erik S.
    329 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0673403506.86
    330 rdf:type schema:Person
    331 sg:person.07430571417.64 schema:affiliation https://www.grid.ac/institutes/grid.267313.2
    332 schema:familyName Witkiewicz
    333 schema:givenName Agnieszka K.
    334 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07430571417.64
    335 rdf:type schema:Person
    336 sg:person.0747361420.45 schema:affiliation https://www.grid.ac/institutes/grid.18886.3f
    337 schema:familyName Turner
    338 schema:givenName Nicholas C.
    339 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0747361420.45
    340 rdf:type schema:Person
    341 sg:pub.10.1007/s10637-007-9090-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044972352
    342 https://doi.org/10.1007/s10637-007-9090-3
    343 rdf:type schema:CreativeWork
    344 sg:pub.10.1007/s10637-014-0120-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025489180
    345 https://doi.org/10.1007/s10637-014-0120-7
    346 rdf:type schema:CreativeWork
    347 sg:pub.10.1007/s11060-012-1000-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021196540
    348 https://doi.org/10.1007/s11060-012-1000-7
    349 rdf:type schema:CreativeWork
    350 sg:pub.10.1007/s12094-006-0193-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022594533
    351 https://doi.org/10.1007/s12094-006-0193-7
    352 rdf:type schema:CreativeWork
    353 sg:pub.10.1023/a:1020918107706 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042929581
    354 https://doi.org/10.1023/a:1020918107706
    355 rdf:type schema:CreativeWork
    356 sg:pub.10.1023/a:1022017701871 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037369236
    357 https://doi.org/10.1023/a:1022017701871
    358 rdf:type schema:CreativeWork
    359 sg:pub.10.1023/a:1022077317801 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044718571
    360 https://doi.org/10.1023/a:1022077317801
    361 rdf:type schema:CreativeWork
    362 sg:pub.10.1038/10039 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008891532
    363 https://doi.org/10.1038/10039
    364 rdf:type schema:CreativeWork
    365 sg:pub.10.1038/2594 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025173151
    366 https://doi.org/10.1038/2594
    367 rdf:type schema:CreativeWork
    368 sg:pub.10.1038/26155 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034157082
    369 https://doi.org/10.1038/26155
    370 rdf:type schema:CreativeWork
    371 sg:pub.10.1038/35024111 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036793227
    372 https://doi.org/10.1038/35024111
    373 rdf:type schema:CreativeWork
    374 sg:pub.10.1038/35048096 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051541099
    375 https://doi.org/10.1038/35048096
    376 rdf:type schema:CreativeWork
    377 sg:pub.10.1038/350512a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014976902
    378 https://doi.org/10.1038/350512a0
    379 rdf:type schema:CreativeWork
    380 sg:pub.10.1038/35082500 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034302480
    381 https://doi.org/10.1038/35082500
    382 rdf:type schema:CreativeWork
    383 sg:pub.10.1038/35106065 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029289076
    384 https://doi.org/10.1038/35106065
    385 rdf:type schema:CreativeWork
    386 sg:pub.10.1038/366704a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015821919
    387 https://doi.org/10.1038/366704a0
    388 rdf:type schema:CreativeWork
    389 sg:pub.10.1038/375503a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034728495
    390 https://doi.org/10.1038/375503a0
    391 rdf:type schema:CreativeWork
    392 sg:pub.10.1038/376358a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025277798
    393 https://doi.org/10.1038/376358a0
    394 rdf:type schema:CreativeWork
    395 sg:pub.10.1038/384470a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003821351
    396 https://doi.org/10.1038/384470a0
    397 rdf:type schema:CreativeWork
    398 sg:pub.10.1038/bjc.2011.177 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008185187
    399 https://doi.org/10.1038/bjc.2011.177
    400 rdf:type schema:CreativeWork
    401 sg:pub.10.1038/cdd.2013.5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011666985
    402 https://doi.org/10.1038/cdd.2013.5
    403 rdf:type schema:CreativeWork
    404 sg:pub.10.1038/leu.2011.109 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043900277
    405 https://doi.org/10.1038/leu.2011.109
    406 rdf:type schema:CreativeWork
    407 sg:pub.10.1038/modpathol.2013.209 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029415400
    408 https://doi.org/10.1038/modpathol.2013.209
    409 rdf:type schema:CreativeWork
    410 sg:pub.10.1038/nature03890 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003324113
    411 https://doi.org/10.1038/nature03890
    412 rdf:type schema:CreativeWork
    413 sg:pub.10.1038/nature05268 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039813470
    414 https://doi.org/10.1038/nature05268
    415 rdf:type schema:CreativeWork
    416 sg:pub.10.1038/nature06046 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037045843
    417 https://doi.org/10.1038/nature06046
    418 rdf:type schema:CreativeWork
    419 sg:pub.10.1038/nature07179 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010877750
    420 https://doi.org/10.1038/nature07179
    421 rdf:type schema:CreativeWork
    422 sg:pub.10.1038/nature08460 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002209653
    423 https://doi.org/10.1038/nature08460
    424 rdf:type schema:CreativeWork
    425 sg:pub.10.1038/nature13255 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024625107
    426 https://doi.org/10.1038/nature13255
    427 rdf:type schema:CreativeWork
    428 sg:pub.10.1038/nature13393 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043379007
    429 https://doi.org/10.1038/nature13393
    430 rdf:type schema:CreativeWork
    431 sg:pub.10.1038/ni1324 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017614572
    432 https://doi.org/10.1038/ni1324
    433 rdf:type schema:CreativeWork
    434 sg:pub.10.1038/nm.2377 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015593189
    435 https://doi.org/10.1038/nm.2377
    436 rdf:type schema:CreativeWork
    437 sg:pub.10.1038/nm.2941 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014975189
    438 https://doi.org/10.1038/nm.2941
    439 rdf:type schema:CreativeWork
    440 sg:pub.10.1038/nrc2347 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046912140
    441 https://doi.org/10.1038/nrc2347
    442 rdf:type schema:CreativeWork
    443 sg:pub.10.1038/nrc2399 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033037679
    444 https://doi.org/10.1038/nrc2399
    445 rdf:type schema:CreativeWork
    446 sg:pub.10.1038/nrc2401 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015933644
    447 https://doi.org/10.1038/nrc2401
    448 rdf:type schema:CreativeWork
    449 sg:pub.10.1038/nrc3556 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047168268
    450 https://doi.org/10.1038/nrc3556
    451 rdf:type schema:CreativeWork
    452 sg:pub.10.1038/nrd2907 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035577861
    453 https://doi.org/10.1038/nrd2907
    454 rdf:type schema:CreativeWork
    455 sg:pub.10.1038/onc.2010.154 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014304136
    456 https://doi.org/10.1038/onc.2010.154
    457 rdf:type schema:CreativeWork
    458 sg:pub.10.1038/onc.2013.83 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007412704
    459 https://doi.org/10.1038/onc.2013.83
    460 rdf:type schema:CreativeWork
    461 sg:pub.10.1038/sj.bjc.6604874 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028475821
    462 https://doi.org/10.1038/sj.bjc.6604874
    463 rdf:type schema:CreativeWork
    464 sg:pub.10.1038/sj.onc.1204252 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047429381
    465 https://doi.org/10.1038/sj.onc.1204252
    466 rdf:type schema:CreativeWork
    467 sg:pub.10.1038/sj.onc.1207374 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040628523
    468 https://doi.org/10.1038/sj.onc.1207374
    469 rdf:type schema:CreativeWork
    470 sg:pub.10.1038/sj.onc.1208853 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002551576
    471 https://doi.org/10.1038/sj.onc.1208853
    472 rdf:type schema:CreativeWork
    473 sg:pub.10.1038/sj.onc.1209371 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017363890
    474 https://doi.org/10.1038/sj.onc.1209371
    475 rdf:type schema:CreativeWork
    476 sg:pub.10.1038/srep03623 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025370301
    477 https://doi.org/10.1038/srep03623
    478 rdf:type schema:CreativeWork
    479 sg:pub.10.1186/1471-2407-14-32 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001663760
    480 https://doi.org/10.1186/1471-2407-14-32
    481 rdf:type schema:CreativeWork
    482 sg:pub.10.1186/1479-5876-11-259 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025904273
    483 https://doi.org/10.1186/1479-5876-11-259
    484 rdf:type schema:CreativeWork
    485 sg:pub.10.1186/bcr2419 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050281960
    486 https://doi.org/10.1186/bcr2419
    487 rdf:type schema:CreativeWork
    488 https://app.dimensions.ai/details/publication/pub.1074889471 schema:CreativeWork
    489 https://app.dimensions.ai/details/publication/pub.1075114599 schema:CreativeWork
    490 https://app.dimensions.ai/details/publication/pub.1075192384 schema:CreativeWork
    491 https://app.dimensions.ai/details/publication/pub.1076885269 schema:CreativeWork
    492 https://app.dimensions.ai/details/publication/pub.1076965945 schema:CreativeWork
    493 https://app.dimensions.ai/details/publication/pub.1078763285 schema:CreativeWork
    494 https://app.dimensions.ai/details/publication/pub.1082708534 schema:CreativeWork
    495 https://app.dimensions.ai/details/publication/pub.1082763127 schema:CreativeWork
    496 https://app.dimensions.ai/details/publication/pub.1082903096 schema:CreativeWork
    497 https://doi.org/10.1002/ijc.25091 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001817106
    498 rdf:type schema:CreativeWork
    499 https://doi.org/10.1002/ijc.2910570311 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016789275
    500 rdf:type schema:CreativeWork
    501 https://doi.org/10.1006/excr.1996.0356 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010695968
    502 rdf:type schema:CreativeWork
    503 https://doi.org/10.1006/excr.1997.3776 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019832759
    504 rdf:type schema:CreativeWork
    505 https://doi.org/10.1006/jmbi.1999.2640 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035214587
    506 rdf:type schema:CreativeWork
    507 https://doi.org/10.1016/0092-8674(87)90227-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039798489
    508 rdf:type schema:CreativeWork
    509 https://doi.org/10.1016/0092-8674(91)90101-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011021705
    510 rdf:type schema:CreativeWork
    511 https://doi.org/10.1016/0092-8674(93)90500-p schema:sameAs https://app.dimensions.ai/details/publication/pub.1038576682
    512 rdf:type schema:CreativeWork
    513 https://doi.org/10.1016/0092-8674(94)90572-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1004129838
    514 rdf:type schema:CreativeWork
    515 https://doi.org/10.1016/j.biocel.2003.12.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014247138
    516 rdf:type schema:CreativeWork
    517 https://doi.org/10.1016/j.biochi.2013.10.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022013368
    518 rdf:type schema:CreativeWork
    519 https://doi.org/10.1016/j.ccr.2010.05.025 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045887142
    520 rdf:type schema:CreativeWork
    521 https://doi.org/10.1016/j.ccr.2011.10.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052152545
    522 rdf:type schema:CreativeWork
    523 https://doi.org/10.1016/j.ccr.2012.09.015 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030170421
    524 rdf:type schema:CreativeWork
    525 https://doi.org/10.1016/j.ccr.2012.09.016 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013646138
    526 rdf:type schema:CreativeWork
    527 https://doi.org/10.1016/j.ccr.2013.08.027 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028309133
    528 rdf:type schema:CreativeWork
    529 https://doi.org/10.1016/j.ccr.2014.05.020 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041312538
    530 rdf:type schema:CreativeWork
    531 https://doi.org/10.1016/j.cell.2004.07.025 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042154429
    532 rdf:type schema:CreativeWork
    533 https://doi.org/10.1016/j.cell.2004.08.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028831364
    534 rdf:type schema:CreativeWork
    535 https://doi.org/10.1016/j.cell.2012.12.010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042391763
    536 rdf:type schema:CreativeWork
    537 https://doi.org/10.1016/j.clbc.2013.10.016 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008611099
    538 rdf:type schema:CreativeWork
    539 https://doi.org/10.1016/j.devcel.2010.02.013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045788636
    540 rdf:type schema:CreativeWork
    541 https://doi.org/10.1016/j.ejca.2010.08.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024294569
    542 rdf:type schema:CreativeWork
    543 https://doi.org/10.1016/j.lungcan.2013.11.020 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020719059
    544 rdf:type schema:CreativeWork
    545 https://doi.org/10.1016/s0065-230x(08)60834-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029640191
    546 rdf:type schema:CreativeWork
    547 https://doi.org/10.1016/s0092-8674(00)00093-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044284876
    548 rdf:type schema:CreativeWork
    549 https://doi.org/10.1016/s0092-8674(00)81902-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026392285
    550 rdf:type schema:CreativeWork
    551 https://doi.org/10.1016/s0955-0674(00)00278-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012858292
    552 rdf:type schema:CreativeWork
    553 https://doi.org/10.1016/s0955-0674(98)80121-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1031728193
    554 rdf:type schema:CreativeWork
    555 https://doi.org/10.1016/s0968-0004(00)89005-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001616450
    556 rdf:type schema:CreativeWork
    557 https://doi.org/10.1016/s1470-2045(08)70208-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010029253
    558 rdf:type schema:CreativeWork
    559 https://doi.org/10.1016/s1470-2045(14)71159-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053530404
    560 rdf:type schema:CreativeWork
    561 https://doi.org/10.1021/jm0305568 schema:sameAs https://app.dimensions.ai/details/publication/pub.1055948192
    562 rdf:type schema:CreativeWork
    563 https://doi.org/10.1021/jm049354h schema:sameAs https://app.dimensions.ai/details/publication/pub.1055949017
    564 rdf:type schema:CreativeWork
    565 https://doi.org/10.1021/jm049355+ schema:sameAs https://app.dimensions.ai/details/publication/pub.1055949018
    566 rdf:type schema:CreativeWork
    567 https://doi.org/10.1038/sj.emboj.7600459 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006859251
    568 rdf:type schema:CreativeWork
    569 https://doi.org/10.1053/j.gastro.2010.01.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028001058
    570 rdf:type schema:CreativeWork
    571 https://doi.org/10.1056/nejmc0808558 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003112265
    572 rdf:type schema:CreativeWork
    573 https://doi.org/10.1073/pnas.1001613107 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011006242
    574 rdf:type schema:CreativeWork
    575 https://doi.org/10.1073/pnas.101004498 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032439010
    576 rdf:type schema:CreativeWork
    577 https://doi.org/10.1073/pnas.1014835108 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053239509
    578 rdf:type schema:CreativeWork
    579 https://doi.org/10.1073/pnas.1314302110 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021403484
    580 rdf:type schema:CreativeWork
    581 https://doi.org/10.1073/pnas.92.19.8871 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051442757
    582 rdf:type schema:CreativeWork
    583 https://doi.org/10.1073/pnas.93.13.6488 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045895978
    584 rdf:type schema:CreativeWork
    585 https://doi.org/10.1073/pnas.93.20.11173 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016453679
    586 rdf:type schema:CreativeWork
    587 https://doi.org/10.1073/pnas.95.3.1091 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015650254
    588 rdf:type schema:CreativeWork
    589 https://doi.org/10.1073/pnas.98.4.1682 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046239571
    590 rdf:type schema:CreativeWork
    591 https://doi.org/10.1074/jbc.m112.365494 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014575863
    592 rdf:type schema:CreativeWork
    593 https://doi.org/10.1074/jbc.m600197200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044159237
    594 rdf:type schema:CreativeWork
    595 https://doi.org/10.1083/jcb.152.5.945 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028936756
    596 rdf:type schema:CreativeWork
    597 https://doi.org/10.1083/jcb.200909144 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052347020
    598 rdf:type schema:CreativeWork
    599 https://doi.org/10.1093/annonc/mdp377 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025440152
    600 rdf:type schema:CreativeWork
    601 https://doi.org/10.1093/jnci/djs002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011154852
    602 rdf:type schema:CreativeWork
    603 https://doi.org/10.1098/rstb.2011.0274 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032451639
    604 rdf:type schema:CreativeWork
    605 https://doi.org/10.1101/gad.1023602 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037936691
    606 rdf:type schema:CreativeWork
    607 https://doi.org/10.1101/gad.11.11.1479 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048904790
    608 rdf:type schema:CreativeWork
    609 https://doi.org/10.1101/gad.11.8.957 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013487101
    610 rdf:type schema:CreativeWork
    611 https://doi.org/10.1101/gad.12.15.2278 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014014091
    612 rdf:type schema:CreativeWork
    613 https://doi.org/10.1101/gad.12.22.3499 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035234284
    614 rdf:type schema:CreativeWork
    615 https://doi.org/10.1101/gad.13.12.1501 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029101666
    616 rdf:type schema:CreativeWork
    617 https://doi.org/10.1101/gad.181933.111 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002261620
    618 rdf:type schema:CreativeWork
    619 https://doi.org/10.1101/gad.244368.114 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006327592
    620 rdf:type schema:CreativeWork
    621 https://doi.org/10.1101/gad.7.3.331 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000187410
    622 rdf:type schema:CreativeWork
    623 https://doi.org/10.1101/gad.7.8.1572 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007024026
    624 rdf:type schema:CreativeWork
    625 https://doi.org/10.1101/gad.8.1.9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052772922
    626 rdf:type schema:CreativeWork
    627 https://doi.org/10.1101/gad.829500 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019696649
    628 rdf:type schema:CreativeWork
    629 https://doi.org/10.1101/gad.851100 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031575679
    630 rdf:type schema:CreativeWork
    631 https://doi.org/10.1101/gad.9.15.1831 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029170181
    632 rdf:type schema:CreativeWork
    633 https://doi.org/10.1101/gad.949802 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012307300
    634 rdf:type schema:CreativeWork
    635 https://doi.org/10.1111/pcmr.12228 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027259447
    636 rdf:type schema:CreativeWork
    637 https://doi.org/10.1126/science.274.5293.1672 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062555127
    638 rdf:type schema:CreativeWork
    639 https://doi.org/10.1126/science.8266103 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062653911
    640 rdf:type schema:CreativeWork
    641 https://doi.org/10.1128/mcb.14.3.2066 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014240465
    642 rdf:type schema:CreativeWork
    643 https://doi.org/10.1128/mcb.15.5.2600 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035576061
    644 rdf:type schema:CreativeWork
    645 https://doi.org/10.1128/mcb.16.5.2402 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013138584
    646 rdf:type schema:CreativeWork
    647 https://doi.org/10.1128/mcb.21.12.4032-4045.2001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000076084
    648 rdf:type schema:CreativeWork
    649 https://doi.org/10.1128/mcb.25.24.10875-10894.2005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015716676
    650 rdf:type schema:CreativeWork
    651 https://doi.org/10.1128/mcb.25.9.3752-3762.2005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007364154
    652 rdf:type schema:CreativeWork
    653 https://doi.org/10.1158/0008-5472.can-03-0110 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043727339
    654 rdf:type schema:CreativeWork
    655 https://doi.org/10.1158/0008-5472.can-04-1613 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052185856
    656 rdf:type schema:CreativeWork
    657 https://doi.org/10.1158/0008-5472.can-05-2507 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045773698
    658 rdf:type schema:CreativeWork
    659 https://doi.org/10.1158/0008-5472.can-07-6404 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047891167
    660 rdf:type schema:CreativeWork
    661 https://doi.org/10.1158/0008-5472.can-08-2473 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007120419
    662 rdf:type schema:CreativeWork
    663 https://doi.org/10.1158/0008-5472.can-09-4559 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048912946
    664 rdf:type schema:CreativeWork
    665 https://doi.org/10.1158/0008-5472.can-13-2247 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004952509
    666 rdf:type schema:CreativeWork
    667 https://doi.org/10.1158/0008-5472.can-13-2923 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028370514
    668 rdf:type schema:CreativeWork
    669 https://doi.org/10.1158/0008-5472.sabcs12-s1-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063222235
    670 rdf:type schema:CreativeWork
    671 https://doi.org/10.1158/1078-0432.ccr-10-2307 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013878313
    672 rdf:type schema:CreativeWork
    673 https://doi.org/10.1158/1078-0432.ccr-11-0244 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048281007
    674 rdf:type schema:CreativeWork
    675 https://doi.org/10.1158/1078-0432.ccr-11-0509 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050917004
    676 rdf:type schema:CreativeWork
    677 https://doi.org/10.1158/1078-0432.ccr-13-1551 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033297283
    678 rdf:type schema:CreativeWork
    679 https://doi.org/10.1158/1078-0432.ccr-13-1675 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025477028
    680 rdf:type schema:CreativeWork
    681 https://doi.org/10.1158/1078-0432.ccr-13-2846 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029418890
    682 rdf:type schema:CreativeWork
    683 https://doi.org/10.1158/1535-7163.mct-06-0355 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053015591
    684 rdf:type schema:CreativeWork
    685 https://doi.org/10.1158/1535-7163.mct-08-0836 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005785454
    686 rdf:type schema:CreativeWork
    687 https://doi.org/10.1158/1535-7163.mct-10-0324 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041876141
    688 rdf:type schema:CreativeWork
    689 https://doi.org/10.1158/1535-7163.mct-11-0963 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040775130
    690 rdf:type schema:CreativeWork
    691 https://doi.org/10.1158/1535-7163.mct-12-0562 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030663352
    692 rdf:type schema:CreativeWork
    693 https://doi.org/10.1158/1535-7163.mct-14-0257 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033447415
    694 rdf:type schema:CreativeWork
    695 https://doi.org/10.1158/1535-7163.mct-14-0387 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007772039
    696 rdf:type schema:CreativeWork
    697 https://doi.org/10.1158/1538-7445.am2014-ct101 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063259112
    698 rdf:type schema:CreativeWork
    699 https://doi.org/10.1158/1541-7786.mcr-13-0350 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023218390
    700 rdf:type schema:CreativeWork
    701 https://doi.org/10.1158/2159-8290.cd-11-0101 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047359970
    702 rdf:type schema:CreativeWork
    703 https://doi.org/10.1158/2159-8290.cd-11-0320 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007349245
    704 rdf:type schema:CreativeWork
    705 https://doi.org/10.1158/2159-8290.cd-nb2014-098 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063281332
    706 rdf:type schema:CreativeWork
    707 https://doi.org/10.1182/blood-2006-04-016634 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031278800
    708 rdf:type schema:CreativeWork
    709 https://doi.org/10.1182/blood-2006-05-020735 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022560846
    710 rdf:type schema:CreativeWork
    711 https://doi.org/10.1182/blood-2011-10-388298 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008456233
    712 rdf:type schema:CreativeWork
    713 https://doi.org/10.1200/jco.1998.16.9.2986 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083316819
    714 rdf:type schema:CreativeWork
    715 https://doi.org/10.1200/jco.2003.09.057 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064205102
    716 rdf:type schema:CreativeWork
    717 https://doi.org/10.1200/jco.2005.03.7689 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064204223
    718 rdf:type schema:CreativeWork
    719 https://doi.org/10.1200/jco.2009.24.1570 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002424810
    720 rdf:type schema:CreativeWork
    721 https://doi.org/10.1200/jco.2009.26.1347 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032892538
    722 rdf:type schema:CreativeWork
    723 https://doi.org/10.1200/jco.2010.28.15_suppl.3060 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083942939
    724 rdf:type schema:CreativeWork
    725 https://doi.org/10.1200/jco.2012.46.5476 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010996175
    726 rdf:type schema:CreativeWork
    727 https://doi.org/10.1200/jco.2013.48.6837 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048428719
    728 rdf:type schema:CreativeWork
    729 https://doi.org/10.1200/jco.2013.52.3993 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019615393
    730 rdf:type schema:CreativeWork
    731 https://doi.org/10.1200/jco.2014.57.1505 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003044785
    732 rdf:type schema:CreativeWork
    733 https://doi.org/10.1242/dev.091744 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043847173
    734 rdf:type schema:CreativeWork
    735 https://doi.org/10.1371/journal.pone.0077639 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023410146
    736 rdf:type schema:CreativeWork
    737 https://doi.org/10.1517/13543784.2013.789859 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035512702
    738 rdf:type schema:CreativeWork
    739 https://doi.org/10.1517/13543784.9.12.2903 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021216762
    740 rdf:type schema:CreativeWork
    741 https://doi.org/10.1530/erc-10-0262 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031547310
    742 rdf:type schema:CreativeWork
    743 https://doi.org/10.18632/genesandcancer.24 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024841874
    744 rdf:type schema:CreativeWork
    745 https://doi.org/10.18632/oncotarget.1568 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037907473
    746 rdf:type schema:CreativeWork
    747 https://doi.org/10.18632/oncotarget.2270 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007950724
    748 rdf:type schema:CreativeWork
    749 https://doi.org/10.2217/fon.10.144 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038505714
    750 rdf:type schema:CreativeWork
    751 https://doi.org/10.2741/bregman schema:sameAs https://app.dimensions.ai/details/publication/pub.1070917737
    752 rdf:type schema:CreativeWork
    753 https://doi.org/10.3109/10428194.2013.783911 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000221542
    754 rdf:type schema:CreativeWork
    755 https://doi.org/10.3892/ijo.9.6.1143 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071517962
    756 rdf:type schema:CreativeWork
    757 https://doi.org/10.4161/auto.23027 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072289687
    758 rdf:type schema:CreativeWork
    759 https://doi.org/10.4161/cbt.72 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072295096
    760 rdf:type schema:CreativeWork
    761 https://doi.org/10.4161/cc.10.15.16776 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072296024
    762 rdf:type schema:CreativeWork
    763 https://doi.org/10.4161/cc.21127 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072296943
    764 rdf:type schema:CreativeWork
    765 https://doi.org/10.4161/cc.21195 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072296947
    766 rdf:type schema:CreativeWork
    767 https://doi.org/10.4161/cc.4.3.1551 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072298251
    768 rdf:type schema:CreativeWork
    769 https://doi.org/10.4161/cc.5.19.3254 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072298621
    770 rdf:type schema:CreativeWork
    771 https://www.grid.ac/institutes/grid.18886.3f schema:alternateName Institute of Cancer Research
    772 schema:name Breakthrough Breast Cancer Research Centre, Chester Beatty Laboratories, Institute of Cancer Research, London, SW3 6JB, UK.
    773 Institute of Cancer Research and Royal Marsden NHS Foundation Trust Breast Cancer Unit, London, SW3 6JJ, UK.
    774 rdf:type schema:Organization
    775 https://www.grid.ac/institutes/grid.267313.2 schema:alternateName The University of Texas Southwestern Medical Center
    776 schema:name Simmons Cancer Center and Department of Pathology, University of Texas Southwestern, Dallas, USA.
    777 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...