Metabolic targets for cancer therapy View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2013-11

AUTHORS

Lorenzo Galluzzi, Oliver Kepp, Matthew G. Vander Heiden, Guido Kroemer

ABSTRACT

Malignant cells exhibit metabolic changes, when compared to their normal counterparts, owing to both genetic and epigenetic alterations. Although such a metabolic rewiring has recently been indicated as yet another general hallmark of cancer, accumulating evidence suggests that the metabolic alterations of each neoplasm represent a molecular signature that intimately accompanies and allows for different facets of malignant transformation. During the past decade, targeting cancer metabolism has emerged as a promising strategy for the development of selective antineoplastic agents. Here, we discuss the intimate relationship between metabolism and malignancy, focusing on strategies through which this central aspect of tumour biology might be turned into cancer's Achilles heel. More... »

PAGES

829-846

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nrd4145

    DOI

    http://dx.doi.org/10.1038/nrd4145

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1015392659

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/24113830


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