Extracellular vesicles: biology and emerging therapeutic opportunities View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2013-05

AUTHORS

Samir EL Andaloussi, Imre Mäger, Xandra O. Breakefield, Matthew J. A. Wood

ABSTRACT

Within the past decade, extracellular vesicles have emerged as important mediators of intercellular communication, being involved in the transmission of biological signals between cells in both prokaryotes and higher eukaryotes to regulate a diverse range of biological processes. In addition, pathophysiological roles for extracellular vesicles are beginning to be recognized in diseases including cancer, infectious diseases and neurodegenerative disorders, highlighting potential novel targets for therapeutic intervention. Moreover, both unmodified and engineered extracellular vesicles are likely to have applications in macromolecular drug delivery. Here, we review recent progress in understanding extracellular vesicle biology and the role of extracellular vesicles in disease, discuss emerging therapeutic opportunities and consider the associated challenges. More... »

PAGES

347-357

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nrd3978

    DOI

    http://dx.doi.org/10.1038/nrd3978

    DIMENSIONS

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    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/23584393


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