Targeting IL-17 and TH17 cells in chronic inflammation View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2012-10-01

AUTHORS

Pierre Miossec, Jay K. Kolls

ABSTRACT

Key PointsInterleukin-17 (IL-17) is a pro-inflammatory cytokine that contributes to the pathogenesis of several inflammatory diseases.The key IL-17 family members are IL-17A and IL-17F, which share a 50% sequence homology. They bind to an IL-17 receptor (IL-17R) complex that is composed of two chains, known as IL-17RA and IL-17RC. IL-17A and IL-17F interact with inflammatory cytokines such as IL-1 and tumour necrosis factor, often in a synergistic manner.IL-17A and IL-17F are the key cytokines produced by T helper 17 (TH17) cells. These cells are crucial for the control of infections, especially extracellular bacterial and fungal infections. They also contribute to epithelial and mucosal protection.Overexpression of IL-17 and TH17 cells contributes to tissue inflammation that is accompanied by matrix destruction, autoimmunity and vascular activation.Positive results have been obtained in clinical trials with two monoclonal antibodies against IL-17A in psoriasis, rheumatoid arthritis and ankylosing spondylitis. Positive results in a clinical trial in psoriasis have been obtained with a monoclonal antibody targeting IL-17RA.Dual inhibitors of IL-17A and IL-17F, of IL-17A and tumour necrosis factor as well as inhibitors of IL-17R signalling are at the preclinical stage of development. More... »

PAGES

763-776

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  • Journal

    TITLE

    Nature Reviews Drug Discovery

    ISSUE

    10

    VOLUME

    11

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nrd3794

    DOI

    http://dx.doi.org/10.1038/nrd3794

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1005892329

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/23023676


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